(16 nodes) Translesion synthesis by POLK network (Fasciola gigantica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGIG_01636	DNA repair protein REV1. (1161 aa)
	FGIG_07731	Replication factor c subunit 2. (333 aa)
	FGIG_08676	Replication factor C subunit 1. (1094 aa)
	FGIG_03354	AAA domain-containing protein. (993 aa)
	FGIG_11300	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	FGIG_09068	DNA replication factor c subunit. (325 aa)
	FGIG_08506	Polyubiquitin. (192 aa)
	FGIG_12152	Polyubiquitine protein. (136 aa)
	FGIG_08854	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (494 aa)
	FGIG_08612	Replication factor C subunit. (357 aa)
	FGIG_01727	Uncharacterized protein. (559 aa)
	FGIG_06877	Replication factor C subunit 3. (345 aa)
	FGIG_08445	Dna polymerase kappa. (328 aa)
	FGIG_11723	Small subunit ribosomal protein S27Ae. (149 aa)
	FGIG_02776	DNA polymerase. (874 aa)
	FGIG_11524	Putative DNA polymerase zeta catalytic subunit. (372 aa)

Your Current Organism:

Fasciola gigantica

NCBI taxonomy Id: 46835
Other names: F. gigantica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGIG_01636	FGIG_01727	A0A504YX68	A0A504Y9Q4	DNA repair protein REV1.	Uncharacterized protein.	0.632
FGIG_01636	FGIG_02776	A0A504YX68	A0A504Z2U5	DNA repair protein REV1.	DNA polymerase.	0.985
FGIG_01636	FGIG_03354	A0A504YX68	A0A504YKU4	DNA repair protein REV1.	AAA domain-containing protein.	0.681
FGIG_01636	FGIG_06877	A0A504YX68	A0A504Y8Z2	DNA repair protein REV1.	Replication factor C subunit 3.	0.740
FGIG_01636	FGIG_07731	A0A504YX68	A0A504YUI6	DNA repair protein REV1.	Replication factor c subunit 2.	0.740
FGIG_01636	FGIG_08445	A0A504YX68	A0A504Y7C2	DNA repair protein REV1.	Dna polymerase kappa.	0.983
FGIG_01636	FGIG_08506	A0A504YX68	A0A504YHV3	DNA repair protein REV1.	Polyubiquitin.	0.955
FGIG_01636	FGIG_08612	A0A504YX68	A0A504YAJ8	DNA repair protein REV1.	Replication factor C subunit.	0.740
FGIG_01636	FGIG_08676	A0A504YX68	A0A504YPC4	DNA repair protein REV1.	Replication factor C subunit 1.	0.717
FGIG_01636	FGIG_08854	A0A504YX68	A0A504YAR6	DNA repair protein REV1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.691
FGIG_01636	FGIG_09068	A0A504YX68	A0A504YJA9	DNA repair protein REV1.	DNA replication factor c subunit.	0.740
FGIG_01636	FGIG_11300	A0A504YX68	A0A504YK62	DNA repair protein REV1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.990
FGIG_01636	FGIG_11524	A0A504YX68	A0A504Z278	DNA repair protein REV1.	Putative DNA polymerase zeta catalytic subunit.	0.985
FGIG_01636	FGIG_11723	A0A504YX68	A0A504Z6K4	DNA repair protein REV1.	Small subunit ribosomal protein S27Ae.	0.958
FGIG_01636	FGIG_12152	A0A504YX68	A0A504YBE5	DNA repair protein REV1.	Polyubiquitine protein.	0.954
FGIG_01727	FGIG_01636	A0A504Y9Q4	A0A504YX68	Uncharacterized protein.	DNA repair protein REV1.	0.632
FGIG_01727	FGIG_02776	A0A504Y9Q4	A0A504Z2U5	Uncharacterized protein.	DNA polymerase.	0.715
FGIG_01727	FGIG_03354	A0A504Y9Q4	A0A504YKU4	Uncharacterized protein.	AAA domain-containing protein.	0.810
FGIG_01727	FGIG_06877	A0A504Y9Q4	A0A504Y8Z2	Uncharacterized protein.	Replication factor C subunit 3.	0.791
FGIG_01727	FGIG_07731	A0A504Y9Q4	A0A504YUI6	Uncharacterized protein.	Replication factor c subunit 2.	0.810