STRINGSTRING
Cwoe_0002 Cwoe_0002 recF recF Cwoe_0004 Cwoe_0004 gyrB gyrB gyrA gyrA Cwoe_0315 Cwoe_0315 dinB dinB Cwoe_0727 Cwoe_0727 Cwoe_0825 Cwoe_0825 Cwoe_0975 Cwoe_0975 Cwoe_1180 Cwoe_1180 radA radA Cwoe_1803 Cwoe_1803 Cwoe_1838 Cwoe_1838 Cwoe_2834 Cwoe_2834 polA polA uvrB uvrB uvrA uvrA Cwoe_2960 Cwoe_2960 sbcD sbcD dnaG dnaG Cwoe_3186 Cwoe_3186 recA recA recX recX Cwoe_3589 Cwoe_3589 Cwoe_3606 Cwoe_3606 priA priA Cwoe_3741 Cwoe_3741 Cwoe_4248 Cwoe_4248 Cwoe_4251 Cwoe_4251 lexA lexA uvrC uvrC mfd mfd recR recR Cwoe_5292 Cwoe_5292 dnaX dnaX Cwoe_5416 Cwoe_5416 Cwoe_5824 Cwoe_5824 Cwoe_5859 Cwoe_5859 Cwoe_5911 Cwoe_5911 Cwoe_5914 Cwoe_5914
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Cwoe_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (369 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (370 aa)
Cwoe_0004PFAM: protein of unknown function DUF721; KEGG: gme:Gmet_2875 hypothetical protein. (105 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (808 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (883 aa)
Cwoe_0315KEGG: maq:Maqu_0559 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. (698 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (358 aa)
Cwoe_0727PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: bam:Bamb_1999 ABC transporter related. (752 aa)
Cwoe_0825KEGG: scl:sce3415 DNA topoisomerase III; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. (598 aa)
Cwoe_0975RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (285 aa)
Cwoe_1180PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; KEGG: scl:sce7572 DNA polymerase III, epsilon subunit. (259 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (466 aa)
Cwoe_1803KEGG: bav:BAV3380 DNA topoisomerase III; TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. (754 aa)
Cwoe_1838KEGG: xca:xccb100_4144 hypothetical protein. (367 aa)
Cwoe_2834TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: gme:Gmet_2298 DNA polymerase III, delta subunit. (325 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (884 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (678 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (964 aa)
Cwoe_2960KEGG: afw:Anae109_2144 DNA repair exonuclease, SbcC. (1191 aa)
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (390 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (641 aa)
Cwoe_3186TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: afw:Anae109_1327 single-stranded-DNA-specific exonuclease RecJ. (846 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (360 aa)
recXRegulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (179 aa)
Cwoe_3589PFAM: UvrD/REP helicase; KEGG: gme:Gmet_0089 ATP-dependent DNA helicase PcrA. (746 aa)
Cwoe_3606KEGG: sfu:Sfum_1225 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein. (1178 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (745 aa)
Cwoe_3741KEGG: scl:sce3415 DNA topoisomerase III; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; HRDC domain protein; SMART: DEAD-like helicase; helicase domain protein. (705 aa)
Cwoe_4248KEGG: ade:Adeh_1612 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1268 aa)
Cwoe_4251KEGG: bgl:bglu_1g31550 hypothetical protein. (395 aa)
lexATranscriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (204 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (647 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1112 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (212 aa)
Cwoe_5292Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (113 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (724 aa)
Cwoe_5416KEGG: gsu:GSU2230 DNA polymerase III, delta prime subunit. (373 aa)
Cwoe_5824PFAM: UvrD/REP helicase; KEGG: ank:AnaeK_0104 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1052 aa)
Cwoe_5859PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; KEGG: aeh:Mlg_2860 DNA polymerase I. (289 aa)
Cwoe_5911Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (157 aa)
Cwoe_5914Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (453 aa)
Your Current Organism:
Conexibacter woesei DSM 14684
NCBI taxonomy Id: 469383
Other names: C. woesei DSM 14684, Conexibacter woesei str. DSM 14684, Conexibacter woesei strain DSM 14684
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