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rpsI rpsI rplM rplM Cwoe_1803 Cwoe_1803 Cwoe_1609 Cwoe_1609 rplQ rplQ rpsK rpsK rpsM rpsM rpmJ rpmJ rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rplP rplP rpmH rpmH Cwoe_5943 Cwoe_5943 Cwoe_5942 Cwoe_5942 Cwoe_5914 Cwoe_5914 rplI rplI rpsR rpsR rpsF rpsF Cwoe_5868 Cwoe_5868 rpsD rpsD Cwoe_5491 Cwoe_5491 Cwoe_5292 Cwoe_5292 recR recR rplY rplY Cwoe_4668 Cwoe_4668 rpmE rpmE Cwoe_4600 Cwoe_4600 Cwoe_4191 Cwoe_4191 Cwoe_3741 Cwoe_3741 priA priA Cwoe_3721 Cwoe_3721 rpmB rpmB rpmF rpmF smc smc rpsP rpsP gyrB gyrB gyrA gyrA Cwoe_0009 Cwoe_0009 Cwoe_0734 Cwoe_0734 Cwoe_0780 Cwoe_0780 Cwoe_0825 Cwoe_0825 rpmG rpmG rplK rplK rplA rplA rplJ rplJ rplL rplL rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rpsZ rpsZ rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rimM rimM rplS rplS rpmI rpmI rplT rplT rpsB rpsB Cwoe_3430 Cwoe_3430 Cwoe_3273 Cwoe_3273 rpsO rpsO dnaG dnaG recO recO Cwoe_3048 Cwoe_3048 Cwoe_2872 Cwoe_2872 rpsT rpsT rpmA rpmA rplU rplU rpsJ-2 rpsJ-2 Cwoe_2077 Cwoe_2077 Cwoe_2019 Cwoe_2019
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpsIPFAM: ribosomal protein S9; KEGG: pfs:PFLU0840 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (264 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa)
Cwoe_1803KEGG: bav:BAV3380 DNA topoisomerase III; TIGRFAM: DNA topoisomerase III; PFAM: DNA topoisomerase type IA central domain protein; TOPRIM domain protein; SMART: DNA topoisomerase I DNA-binding; DNA topoisomerase I ATP-binding; Toprim sub domain protein. (754 aa)
Cwoe_1609KEGG: scl:sce7580 hypothetical protein. (575 aa)
rplQTIGRFAM: ribosomal protein L17; PFAM: ribosomal protein L17; KEGG: pca:Pcar_0729 50S ribosomal protein L17. (117 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (132 aa)
rpsM30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (126 aa)
rpmJTIGRFAM: ribosomal protein L36; PFAM: ribosomal protein L36; KEGG: dma:DMR_12420 50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (170 aa)
rpmDTIGRFAM: ribosomal protein L30; PFAM: ribosomal protein L30; KEGG: eca:ECA4013 50S ribosomal protein L30. (61 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (197 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (135 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa)
rpmHTIGRFAM: ribosomal protein L34; PFAM: ribosomal protein L34; KEGG: cbg:CbuG_0026 50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
Cwoe_5943PFAM: Cobyrinic acid ac-diamide synthase; KEGG: glo:Glov_3177 cobyrinic acid ac-diamide synthase. (252 aa)
Cwoe_5942KEGG: xca:xccb100_4034 chromosome partitioning protein; TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; Belongs to the ParB family. (295 aa)
Cwoe_5914Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (453 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (150 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (108 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (124 aa)
Cwoe_5868PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: ank:AnaeK_0767 recombination factor protein RarA. (427 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (210 aa)
Cwoe_5491PFAM: transferase hexapeptide repeat containing protein; KEGG: glo:Glov_1509 transferase hexapeptide repeat containing protein. (219 aa)
Cwoe_5292Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (113 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (212 aa)
rplYRibosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (218 aa)
Cwoe_4668PFAM: Cobyrinic acid ac-diamide synthase; KEGG: mei:Msip34_2824 cobyrinic acid ac-diamide synthase. (255 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (73 aa)
Cwoe_4600TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA; KEGG: noc:Noc_2794 sigma 54 modulation protein/ribosomal protein S30EA. (117 aa)
Cwoe_4191PFAM: ATP-dependent Clp protease adaptor protein ClpS; KEGG: hypothetical protein. (95 aa)
Cwoe_3741KEGG: scl:sce3415 DNA topoisomerase III; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; HRDC domain protein; SMART: DEAD-like helicase; helicase domain protein. (705 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (745 aa)
Cwoe_3721Hypothetical protein. (75 aa)
rpmBTIGRFAM: ribosomal protein L28; PFAM: ribosomal protein L28; KEGG: ank:AnaeK_2611 50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
rpmFTIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein; KEGG: geo:Geob_2610 ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (64 aa)
smcSMC domain protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1081 aa)
rpsPTIGRFAM: ribosomal protein S16; PFAM: ribosomal protein S16; KEGG: ppd:Ppro_1098 30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (84 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (808 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (883 aa)
Cwoe_0009Hypothetical protein. (178 aa)
Cwoe_0734PFAM: protein of unknown function DUF74; KEGG: bra:BRADO6695 hypothetical protein; Belongs to the UPF0145 family. (111 aa)
Cwoe_0780PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: pap:PSPA7_3983 hypothetical protein. (147 aa)
Cwoe_0825KEGG: scl:sce3415 DNA topoisomerase III; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. (598 aa)
rpmGTIGRFAM: ribosomal protein L33; PFAM: ribosomal protein L33; KEGG: dat:HRM2_36400 RpmG; Belongs to the bacterial ribosomal protein bL33 family. (54 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (140 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (242 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (256 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (126 aa)
rpsLRibosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (131 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (108 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (205 aa)
rplDRibosomal protein L4/L1e; Forms part of the polypeptide exit tunnel. (210 aa)
rplWRibosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (279 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (90 aa)
rplVRibosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (212 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (395 aa)
rpsZRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpmCTIGRFAM: ribosomal protein L29; PFAM: ribosomal protein L29; KEGG: dvm:DvMF_0087 50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (72 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (190 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (106 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (193 aa)
rimM16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (211 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (196 aa)
rpmITIGRFAM: ribosomal protein L35; PFAM: ribosomal protein L35; KEGG: nis:NIS_0110 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (121 aa)
rpsBTIGRFAM: ribosomal protein S2; PFAM: ribosomal protein S2; KEGG: dal:Dalk_3165 ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (420 aa)
Cwoe_3430KEGG: reh:H16_A1489 DNA topoisomerase IB. (342 aa)
Cwoe_3273PFAM: protein of unknown function DUF159; KEGG: gsu:GSU0040 hypothetical protein; Belongs to the SOS response-associated peptidase family. (248 aa)
rpsORibosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (90 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (641 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (248 aa)
Cwoe_3048PFAM: adenylate cyclase; KEGG: dma:DMR_03490 putative adenylate cyclase. (179 aa)
Cwoe_2872PFAM: RNA binding S1 domain protein; KEGG: bba:Bd1066 30S ribosomal protein S1. (529 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (90 aa)
rpmATIGRFAM: ribosomal protein L27; PFAM: ribosomal protein L27; KEGG: cja:CJA_0459 ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (90 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (114 aa)
rpsJ-2Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (106 aa)
Cwoe_2077KEGG: pmr:PMI3605 cell division protein. (136 aa)
Cwoe_2019PFAM: Cobyrinic acid ac-diamide synthase; KEGG: sbm:Shew185_2565 cobyrinic acid ac-diamide synthase. (340 aa)
Your Current Organism:
Conexibacter woesei DSM 14684
NCBI taxonomy Id: 469383
Other names: C. woesei DSM 14684, Conexibacter woesei str. DSM 14684, Conexibacter woesei strain DSM 14684
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