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| purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (389 aa) | ||||
| EDV02834.1 | Putative DNA-binding protein. (175 aa) | ||||
| EDV02843.1 | COG: COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (196 aa) | ||||
| traN | Conjugative transposon TraN protein; COG: NOG26275 non supervised orthologous group. (332 aa) | ||||
| EDV02661.1 | Putative DNA-binding protein; COG: NOG34048 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.96. (125 aa) | ||||
| EDV02671.1 | Hypothetical protein; KEGG: rba:RB3532 8.6e-09 similar to alkaline phosphatase PhoA K01077; COG: NOG12131 non supervised orthologous group. (498 aa) | ||||
| EDV02674.1 | Putative DNA-binding protein; COG: NOG34048 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.96. (136 aa) | ||||
| EDV02630.1 | Helicase C-terminal domain protein; KEGG: bth:BT4517 7.3e-255 Type I restriction enzyme EcoKI R protein K01153; COG: COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases; Psort location: Cytoplasmic, score: 8.96. (560 aa) | ||||
| EDV02597.1 | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; KEGG: bfr:BF1478 1.1e-267 phosphoglucomutase phosphomannomutase K01840; COG: COG1109 Phosphomannomutase. (581 aa) | ||||
| EDV02625.1 | 5'-nucleotidase, C-terminal domain protein; KEGG: bth:BT1236 1.4e-198 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor K01119; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score: 9.76; Belongs to the 5'-nucleotidase family. (581 aa) | ||||
| pyk | Pyruvate kinase; KEGG: bth:BT2841 1.1e-210 pyruvate kinase K00873; COG: COG0469 Pyruvate kinase; Psort location: Cytoplasmic, score: 8.96. (486 aa) | ||||
| EDV02531.1 | Hydrolase, NUDIX family; KEGG: bfr:BF4292 1.2e-55 putative Nudix/MutT family protein K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: Cytoplasmic, score: 8.96. (184 aa) | ||||
| EDV02408.1 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (269 aa) | ||||
| EDV02438.1 | Hypothetical protein; KEGG: lpl:lp_3251 2.4e-05 3',5'-cyclic-nucleotide phosphodiesterase K01120; COG: COG1409 Predicted phosphohydrolases; Psort location: Cytoplasmic, score: 8.96. (477 aa) | ||||
| prs | KEGG: bth:BT0748 1.4e-125 ribose-phosphate pyrophosphokinase K00948; COG: COG0462 Phosphoribosylpyrophosphate synthetase. (280 aa) | ||||
| EDV02396.1 | Ser/Thr phosphatase family protein; KEGG: ath:At1g14700 2.6e-30 F10B6.10; purple acid phosphatase, putative K01078; COG: NOG23395 non supervised orthologous group. (314 aa) | ||||
| EDV02307.1 | Histidine triad domain protein; KEGG: reh:H16_A0281 3.6e-17 diadenosine tetraphosphate (Ap4A) hydrolase K01518; COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: Cytoplasmic, score: 8.96. (134 aa) | ||||
| EDV02334.1 | Adenylate cyclase; KEGG: ava:Ava_1972 2.2e-33 putative adenylate cyclase family protein K01768; COG: COG2954 Uncharacterized protein conserved in bacteria; Psort location: Cytoplasmic, score: 8.96. (158 aa) | ||||
| EDV02291.1 | Hypothetical protein; COG: COG1284 Uncharacterized conserved protein; Psort location: CytoplasmicMembrane, score: 10.00. (320 aa) | ||||
| EDV02212.1 | Hypothetical protein; KEGG: ava:Ava_1170 1.3e-17 metallophosphoesterase K01078; COG: COG1409 Predicted phosphohydrolases. (213 aa) | ||||
| EDV02213.1 | Purple acid phosphatase; COG: COG1409 Predicted phosphohydrolases. (181 aa) | ||||
| EDV02173.1 | Hypothetical protein; COG: COG1284 Uncharacterized conserved protein. (91 aa) | ||||
| guaA | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. (517 aa) | ||||
| EDV02161.1 | Hypothetical protein; COG: COG1284 Uncharacterized conserved protein; Psort location: CytoplasmicMembrane, score: 10.00. (295 aa) | ||||
| EDV02029.1 | Ppx/GppA phosphatase family protein; KEGG: bth:BT0540 6.1e-93 putative exopolyphosphatase K01514; COG: COG0248 Exopolyphosphatase; Psort location: Cytoplasmic, score: 8.96. (306 aa) | ||||
| EDV02041.1 | TIGR00730 family protein; KEGG: reh:H16_A1025 6.1e-38 predicted Rossmann fold nucleotide-binding protein / lysine decarboxylase family protein K01592; COG: COG1611 Predicted Rossmann fold nucleotide-binding protein; Psort location: Cytoplasmic, score: 8.96; Belongs to the LOG family. (195 aa) | ||||
| EDV02056.1 | Hypothetical protein; COG: COG1284 Uncharacterized conserved protein; Psort location: CytoplasmicMembrane, score: 9.46. (298 aa) | ||||
| rdgB | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (194 aa) | ||||
| ychF | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (367 aa) | ||||
| apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa) | ||||
| traN-2 | Conjugative transposon TraN protein; COG: NOG26275 non supervised orthologous group. (306 aa) | ||||
| EDV01784.1 | PP-loop family protein; KEGG: nme:NMB1023 8.5e-32 hypothetical protein K04075; COG: COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; Belongs to the TtcA family. (249 aa) | ||||
| purN | Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa) | ||||
| EDV01669.1 | Class II glutamine amidotransferase; KEGG: chu:CHU_2612 9.0e-163 purF; amidophosphoribosyltransferase K00764; COG: COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase; Psort location: Cytoplasmic, score: 8.96. (627 aa) | ||||
| EDV01565.1 | TIGR00730 family protein; KEGG: reh:H16_A1025 8.4e-25 predicted Rossmann fold nucleotide-binding protein / lysine decarboxylase family protein K01592; COG: COG1611 Predicted Rossmann fold nucleotide-binding protein; Belongs to the LOG family. (178 aa) | ||||
| EDV01388.1 | MazG family protein; KEGG: pha:PSHAa0740 6.3e-43 mazG; nucleoside triphosphate pyrophosphohydrolase, non-specific K02428; COG: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; Psort location: Cytoplasmic, score: 8.96. (261 aa) | ||||
| EDV01403.1 | RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (738 aa) | ||||
| purL | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1234 aa) | ||||
| EDV01277.1 | Putative conjugative transposon TraN protein; COG: NOG30051 non supervised orthologous group. (370 aa) | ||||
| hup | DNA-binding protein HU; COG: COG0776 Bacterial nucleoid DNA-binding protein; Belongs to the bacterial histone-like protein family. (94 aa) | ||||
| traN-3 | Conjugative transposon TraN protein; COG: NOG26275 non supervised orthologous group. (283 aa) | ||||
| traN-4 | Conjugative transposon TraN protein; COG: NOG26275 non supervised orthologous group. (328 aa) | ||||
| hup-2 | DNA-binding protein HU; COG: COG0776 Bacterial nucleoid DNA-binding protein; Belongs to the bacterial histone-like protein family. (96 aa) | ||||
| hup-3 | DNA-binding protein HU; COG: NOG36317 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.96; Belongs to the bacterial histone-like protein family. (371 aa) | ||||
| EDV00883.1 | KEGG: bfr:BF2395 2.1e-124 AMP nucleosidase K01241; COG: COG0775 Nucleoside phosphorylase. (258 aa) | ||||
| EDV00884.1 | Hypothetical protein; COG: NOG14438 non supervised orthologous group. (149 aa) | ||||
| purB | KEGG: bth:BT3871 4.8e-212 adenylosuccinate lyase K01756; COG: COG0015 Adenylosuccinate lyase; Psort location: Cytoplasmic, score: 8.96. (449 aa) | ||||
| EDV00742.1 | Putative dGTPase; KEGG: bfr:BF0323 3.9e-178 dGTP triphosphohydrolase K01129; COG: COG0232 dGTP triphosphohydrolase; Psort location: Cytoplasmic, score: 8.96. (443 aa) | ||||
| EDV00688.1 | Ser/Thr phosphatase family protein; COG: NOG14436 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.96. (279 aa) | ||||
| tilS | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (426 aa) | ||||
| guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa) | ||||
| uraH | Hydroxyisourate hydrolase; KEGG: gbe:GbCGDNIH1_1243 3.9e-11 urate oxidase K00365; COG: COG2351 Transthyretin-like protein; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (136 aa) | ||||
| purD | KEGG: bth:BT3253 3.9e-178 phosphoribosylamine--glycine ligase K01945; COG: COG0151 Phosphoribosylamine-glycine ligase; Psort location: Cytoplasmic, score: 8.96; Belongs to the GARS family. (424 aa) | ||||
| purH | Putative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: bfr:BF4101 5.0e-224 phosphoribosylaminoimidazole carboxy formyl formyltransferase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.96. (508 aa) | ||||
| mgtE | Magnesium transporter; Acts as a magnesium transporter. (446 aa) | ||||
| EDV00530.1 | Hypothetical protein. (225 aa) | ||||
| EDV00531.1 | Hypothetical protein. (447 aa) | ||||
| EDV00535.1 | Hypothetical protein. (731 aa) | ||||
| truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (252 aa) | ||||
| purC | KEGG: bth:BT4217 5.0e-153 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; COG: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Psort location: Cytoplasmic, score: 8.96; Belongs to the SAICAR synthetase family. (314 aa) | ||||
| EDV00437.1 | KEGG: sil:SPO2904 2.6e-29 Ser/Thr protein phosphatase/nucleotidase, putative K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases. (280 aa) | ||||
| EDV00438.1 | 5'-nucleotidase, C-terminal domain protein; KEGG: cjk:jk1044 1.1e-17 5-nucleotidase/23-cyclic phosphodiesterase and related esterases K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: Periplasmic, score: 9.44. (251 aa) | ||||
| EDV00461.1 | Hypothetical protein; KEGG: bfr:BF0911 2.0e-190 putative phosphoribosylformylglycinamidine cyclo-ligase K01933; COG: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; Psort location: Cytoplasmic, score: 8.96. (383 aa) | ||||
| EDV00317.1 | Hypothetical protein; KEGG: hpa:HPAG1_1423 1.2e-50 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: CytoplasmicMembrane, score: 9.16. (459 aa) | ||||
| EDV00352.1 | Endonuclease/exonuclease/phosphatase family protein; COG: NOG19129 non supervised orthologous group. (345 aa) | ||||
| EDV00374.1 | KEGG: bth:BT4582 4.5e-216 amidophosphoribosyltransferase precursor K00764; COG: COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase; Psort location: Cytoplasmic, score: 8.96; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (468 aa) | ||||
| purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) | ||||
| nrdD | KEGG: bfs:BF3484 0. putative anaerobic ribonucleoside-triphosphate reductase K00527; COG: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; Psort location: Cytoplasmic, score: 8.96. (826 aa) | ||||
| EDU99629.1 | Hypothetical protein; KEGG: hpa:HPAG1_1423 6.9e-37 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: CytoplasmicMembrane, score: 9.16. (418 aa) | ||||
| traN-5 | Conjugative transposon TraN protein; COG: NOG25297 non supervised orthologous group. (311 aa) | ||||
| EDU99690.1 | Hypothetical protein; KEGG: reh:H16_A0442 1.3e-10 diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase K01529; COG: NOG34893 non supervised orthologous group. (141 aa) | ||||
| EDU99704.1 | Hypothetical protein; COG: COG0628 Predicted permease; Psort location: CytoplasmicMembrane, score: 10.00. (338 aa) | ||||
| EDU99721.1 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (847 aa) | ||||
| purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa) | ||||
| EDU99798.1 | COG: COG2086 Electron transfer flavoprotein, beta subunit; Psort location: Cytoplasmic, score: 8.96. (295 aa) | ||||
| EDU99476.1 | KEGG: mac:MA3407 1.4e-47 cytidine/deoxycytidylate deaminase family protein K01487; COG: COG0590 Cytosine/adenosine deaminases; Psort location: Cytoplasmic, score: 8.96. (161 aa) | ||||
| EDU99497.1 | AICARFT/IMPCHase bienzyme; KEGG: dme:Dmel_CG11089 1.5e-119 CG11089 K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.96. (392 aa) | ||||
| adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (189 aa) | ||||
| hpt | KEGG: bfr:BF1119 4.7e-70 putative hypoxanthine guanine phosphoribosyltransferase K00760; COG: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) | ||||
| xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa) | ||||
| gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (187 aa) | ||||
| surE | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (261 aa) | ||||
| EDU99158.1 | RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (757 aa) | ||||
| gldE | Gliding motility-associated protein GldE; KEGG: eci:UTI89_C0656 1.7e-42 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains. (427 aa) | ||||
| hup-4 | DNA-binding protein HU; COG: COG0776 Bacterial nucleoid DNA-binding protein; Belongs to the bacterial histone-like protein family. (91 aa) | ||||
| EDU98934.1 | Helicase C-terminal domain protein; KEGG: bth:BT4517 0. Type I restriction enzyme EcoKI R protein K01153; COG: COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (901 aa) | ||||
| EDU98821.1 | Ser/Thr phosphatase family protein; COG: NOG12131 non supervised orthologous group; Psort location: Cytoplasmic, score: 8.96. (470 aa) | ||||
| cysN | Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (501 aa) | ||||
| cysD | KEGG: bfs:BF1676 3.8e-155 cysD; putative sulfate adenylyltransferase subunit 2 K00957; COG: COG0175 3-phosphoadenosine 5-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes; Psort location: Cytoplasmic, score: 8.96. (303 aa) | ||||
| cysC | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (200 aa) | ||||
| hup-5 | DNA-binding protein HU; COG: COG0776 Bacterial nucleoid DNA-binding protein; Belongs to the bacterial histone-like protein family. (93 aa) | ||||
| EDU98751.1 | KEGG: bth:BT3925 2.3e-61 nucleoside-diphosphate kinase K00940; COG: COG0105 Nucleoside diphosphate kinase; Psort location: Cytoplasmic, score: 9.97; Belongs to the NDK family. (158 aa) | ||||
| EDU98700.1 | Endonuclease/exonuclease/phosphatase family protein; COG: NOG08645 non supervised orthologous group. (342 aa) | ||||