STRINGSTRING
fmt fmt EDV02718.1 EDV02718.1 EDV02795.1 EDV02795.1 metH metH purN purN EDV01469.1 EDV01469.1 EDV01391.1 EDV01391.1 EDV01083.1 EDV01083.1 tgt tgt EDV00850.1 EDV00850.1 glyA glyA purH purH metF metF gcvT gcvT EDV00101.1 EDV00101.1 thyA thyA folA folA EDU99736.1 EDU99736.1 folD folD EDU99497.1 EDU99497.1 EDU99278.1 EDU99278.1 fhs fhs purT purT
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (323 aa)
EDV02718.1Hypothetical protein; KEGG: chu:CHU_1297 0.00021 dfr; dihydrofolate reductase family protein K00287. (150 aa)
EDV02795.1Riboflavin biosynthesis protein RibD C-terminal domain protein; KEGG: pae:PA3469 1.3e-12 hypothetical zinc metalloprotease; COG: COG0262 Dihydrofolate reductase. (172 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (914 aa)
purNPutative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (189 aa)
EDV01469.1KEGG: chu:CHU_3712 9.2e-90 hypothetical protein K00599; COG: COG1092 Predicted SAM-dependent methyltransferases. (395 aa)
EDV01391.1Oxidoreductase; COG: NOG16874 non supervised orthologous group. (155 aa)
EDV01083.1Hypothetical protein; KEGG: chu:CHU_1297 0.00058 dfr; dihydrofolate reductase family protein K00287; Psort location: Cytoplasmic, score: 8.96. (140 aa)
tgttRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (376 aa)
EDV00850.1Hypothetical protein; COG: NOG14440 non supervised orthologous group; Psort location: CytoplasmicMembrane, score: 9.50. (364 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
purHPutative phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: bfr:BF4101 5.0e-224 phosphoribosylaminoimidazole carboxy formyl formyltransferase K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.96. (508 aa)
metFKEGG: bfr:BF4092 1.7e-143 5,10-methylenetetrahydrofolate reductase K00297; COG: COG0685 5,10-methylenetetrahydrofolate reductase; Psort location: Cytoplasmic, score: 8.96. (317 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (362 aa)
EDV00101.1KEGG: bfr:BF0962 3.5e-49 putative 5-formyltetrahydrofolate cyclo-ligase K01934; COG: COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (186 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
EDU99736.1KEGG: eca:ECA3987 1.0e-45 metH; B12-dependent methionine synthase K00548; COG: COG1410 Methionine synthase I, cobalamin-binding domain; Psort location: Cytoplasmic, score: 8.96. (301 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa)
EDU99497.1AICARFT/IMPCHase bienzyme; KEGG: dme:Dmel_CG11089 1.5e-119 CG11089 K00602:K01492; COG: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Psort location: Cytoplasmic, score: 8.96. (392 aa)
EDU99278.1KEGG: aha:AHA_0675 2.5e-11 thyA; thymidylate synthase K00560; COG: COG0207 Thymidylate synthase; Psort location: Cytoplasmic, score: 9.97. (233 aa)
fhsKEGG: bfr:BF2202 2.8e-246 formate-tetrahydrofolate ligase K01938; COG: COG2759 Formyltetrahydrofolate synthetase; Psort location: Cytoplasmic, score: 8.96. (577 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (389 aa)
Your Current Organism:
Bacteroides coprocola
NCBI taxonomy Id: 470145
Other names: B. coprocola DSM 17136, Bacteroides coprocola DSM 17136, Bacteroides coprocola M16, Bacteroides coprocola str. DSM 17136, Bacteroides coprocola strain DSM 17136
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