| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQZ80357.1 | AQZ83712.1 | BUM88_01225 | BUM88_04290 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Catalyzes the formation of porphobilinogen from 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. | 0.840 |
| AQZ80357.1 | cysG | BUM88_01225 | BUM88_15705 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.961 |
| AQZ80357.1 | hemA | BUM88_01225 | BUM88_03980 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.544 |
| AQZ80357.1 | hemC | BUM88_01225 | BUM88_01220 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
| AQZ80357.1 | hemE | BUM88_01225 | BUM88_13510 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.921 |
| AQZ80357.1 | hemH | BUM88_01225 | BUM88_01845 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.439 |
| AQZ80775.1 | AQZ82480.1 | BUM88_03625 | BUM88_13145 | ferredoxin--NADP(+) reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ferredoxin--NADP(+) reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
| AQZ80848.1 | hemF | BUM88_04060 | BUM88_17525 | TIGR00701 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.952 |
| AQZ80848.1 | hemH | BUM88_04060 | BUM88_01845 | TIGR00701 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.943 |
| AQZ80908.1 | cyoE | BUM88_04400 | BUM88_12335 | Biliverdin-producing heme oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 0.900 |
| AQZ80908.1 | hemH | BUM88_04400 | BUM88_01845 | Biliverdin-producing heme oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.900 |
| AQZ82480.1 | AQZ80775.1 | BUM88_13145 | BUM88_03625 | ferredoxin--NADP(+) reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | ferredoxin--NADP(+) reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.913 |
| AQZ82670.1 | AQZ82726.1 | BUM88_14175 | BUM88_14490 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-1-semialdehyde-2,1-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.404 |
| AQZ82670.1 | AQZ83712.1 | BUM88_14175 | BUM88_04290 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catalyzes the formation of porphobilinogen from 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. | 0.698 |
| AQZ82670.1 | cysG | BUM88_14175 | BUM88_15705 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.495 |
| AQZ82670.1 | hemA | BUM88_14175 | BUM88_03980 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.524 |
| AQZ82670.1 | hemC | BUM88_14175 | BUM88_01220 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.946 |
| AQZ82670.1 | hemF | BUM88_14175 | BUM88_17525 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.552 |
| AQZ82670.1 | hemH | BUM88_14175 | BUM88_01845 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.852 |
| AQZ82670.1 | hemL | BUM88_14175 | BUM88_13825 | Uroporphyrinogen decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-1-semialdehyde-2,1-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.404 |