STRINGSTRING
ACS23012.1 ACS23012.1 ACS23013.1 ACS23013.1 ACS23014.1 ACS23014.1 ACS23015.1 ACS23015.1 ACS23016.1 ACS23016.1 ACS23017.1 ACS23017.1 ACS23497.1 ACS23497.1 ACS23608.1 ACS23608.1 ACS23774.1 ACS23774.1 ACS23869.1 ACS23869.1 ACS24019.1 ACS24019.1 ACS24164.1 ACS24164.1 ACS24166.1 ACS24166.1 bioB bioB ACS24767.1 ACS24767.1 ACS24818.1 ACS24818.1 nth nth ACS24820.1 ACS24820.1 ACS24823.1 ACS24823.1 ACS24824.1 ACS24824.1 panD panD panC panC panB panB birA birA cca cca ACS24831.1 ACS24831.1 ACS24832.1 ACS24832.1 mgsA mgsA ACS24835.1 ACS24835.1 ACS24836.1 ACS24836.1 ACS24859.1 ACS24859.1 menG menG ACS24861.1 ACS24861.1 mtrB mtrB folE folE ribH ribH ribBA ribBA ACS24946.1 ACS24946.1 ACS24947.1 ACS24947.1 ACS25293.1 ACS25293.1 ACS25294.1 ACS25294.1 bioA bioA bioD bioD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ACS23012.1PFAM: aminotransferase class IV; KEGG: gtn:GTNG_0068 4-amino-4-deoxychorismate lyase. (290 aa)
ACS23013.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (285 aa)
ACS23014.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa)
ACS23015.1KEGG: gtn:GTNG_0071 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (175 aa)
ACS23016.1Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: gka:GK0072 hypothetical protein. (73 aa)
ACS23017.1PFAM: transposase IS4 family protein; KEGG: npu:Npun_BR216 hypothetical protein. (437 aa)
ACS23497.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (314 aa)
ACS23608.1TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; KEGG: gtn:GTNG_0634 hydrolase HAD superfamily. (268 aa)
ACS23774.1TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; sucrose-6F-phosphate phosphohydrolase; KEGG: afl:Aflv_1943 predicted hydrolase of the HAD superfamily. (268 aa)
ACS23869.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (307 aa)
ACS24019.1TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; Riboflavin kinase; KEGG: gtn:GTNG_1121 bifunctional riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (327 aa)
ACS24164.1Transcriptional regulator, PucR family; PFAM: purine catabolism PurC domain protein; KEGG: gka:GK1425 hypothetical protein. (537 aa)
ACS24166.1PFAM: aminotransferase class-III; KEGG: gtn:GTNG_1286 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa)
ACS24767.18-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (390 aa)
ACS24818.1KEGG: gtn:GTNG_2103 hypothetical protein. (167 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (223 aa)
ACS24820.1TIGRFAM: primosome, DnaD subunit; PFAM: DnaD and phage-associated region; KEGG: gtn:GTNG_2105 DNA replication protein DnaD. (235 aa)
ACS24823.1KEGG: gtn:GTNG_2108 hypothetical protein. (160 aa)
ACS24824.1KEGG: gtn:GTNG_2109 hypothetical protein. (56 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (279 aa)
birABifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (329 aa)
ccaPolynucleotide adenylyltransferase region; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (404 aa)
ACS24831.1PFAM: glycosyl transferase group 1; KEGG: gtn:GTNG_2116 glycosyltransferase. (375 aa)
ACS24832.1PFAM: LmbE family protein; KEGG: afl:Aflv_1122 N-acetylglucosaminylphosphatidylinositol de-N-acetylase related enzyme, LmbE family. (236 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (140 aa)
ACS24835.1PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: gka:GK2186 hypothetical protein. (112 aa)
ACS24836.1PFAM: protein of unknown function DUF161; KEGG: gtn:GTNG_2121 hypothetical membrane spanning protein. (289 aa)
ACS24859.1TIGRFAM: heptaprenyl diphosphate synthase component II; PFAM: Polyprenyl synthetase; KEGG: gtn:GTNG_2144 component II of heptaprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (320 aa)
menG2-heptaprenyl-1,4-naphthoquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (234 aa)
ACS24861.1Trans-hexaprenyltranstransferase; PFAM: Heptaprenyl diphosphate synthase subunit 1; KEGG: gtn:GTNG_2146 component I of heptaprenyl diphosphate synthase. (278 aa)
mtrBTryptophan RNA-binding attenuator protein; Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan. Belongs to the MtrB family. (74 aa)
folEKEGG: gtn:GTNG_2148 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I. (188 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (154 aa)
ribBA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family. (397 aa)
ACS24946.1TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: gtn:GTNG_2224 riboflavin synthase subunit alpha. (215 aa)
ACS24947.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (361 aa)
ACS25293.1TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: gtn:GTNG_2592 hypothetical protein. (169 aa)
ACS25294.1Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (202 aa)
bioAAminotransferase class-III; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (455 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa)
Your Current Organism:
Geobacillus sp. WCH70
NCBI taxonomy Id: 471223
Other names: G. sp. WCH70
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