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| | Fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa) |
| | ALC57_18552 | Breast cancer type 2 susceptibility protein like protein. (1759 aa) |
| | ALC57_18004 | Structure-specific endonuclease subunit SLX4. (1546 aa) |
| | ALC57_17720 | Putative cell division control protein 7 like protein 2; Belongs to the protein kinase superfamily. (370 aa) |
| | ALC57_17675 | Protein timeless like protein. (846 aa) |
| | ALC57_17736 | DNA polymerase iota. (568 aa) |
| | ALC57_16147 | Mediator of DNA damage checkpoint protein 1. (1090 aa) |
| | ALC57_15936 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (857 aa) |
| | ALC57_15888 | Werner Syndrome-like exonuclease. (171 aa) |
| | ALC57_15916 | RecQ-mediated genome instability protein 1. (595 aa) |
| | ALC57_15491 | Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family. (2786 aa) |
| | ALC57_15449 | Sister chromatid cohesion protein DCC1. (408 aa) |
| | ALC57_15085 | DNA helicase; Belongs to the MCM family. (908 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (622 aa) |
| | ALC57_14327 | Replication factor C subunit 5. (210 aa) |
| | ALC57_14133 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (216 aa) |
| | ALC57_14138 | Origin recognition complex subunit 2. (582 aa) |
| | ALC57_14143 | Fanconi anemia group I protein. (1355 aa) |
| | ALC57_14057 | E3 ubiquitin-protein ligase FANCL. (390 aa) |
| | ALC57_13179 | DNA repair and recombination protein RAD54-like protein. (743 aa) |
| | ALC57_12795 | DNA helicase; Belongs to the MCM family. (760 aa) |
| | ALC57_12574 | DNA repair protein RAD50. (1512 aa) |
| | ALC57_10518 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1121 aa) |
| | ALC57_10230 | Origin recognition complex subunit 3. (719 aa) |
| | ALC57_09245 | Replication factor C subunit 2. (356 aa) |
| | ALC57_08875 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (449 aa) |
| | ALC57_07803 | Bloom syndrome protein like protein. (1253 aa) |
| | ALC57_07023 | Mitotic spindle assembly checkpoint protein MAD2B. (109 aa) |
| | ALC57_06560 | Replication factor C subunit 4. (356 aa) |
| | ALC57_06367 | PMS1 protein like protein 1. (733 aa) |
| | ALC57_06354 | Cell division control protein 45 like protein. (590 aa) |
| | ALC57_05899 | Protein timeless like protein. (657 aa) |
| | ALC57_05871 | DDE_Tnp_IS1595 domain-containing protein. (151 aa) |
| | ALC57_05610 | DDE_Tnp_IS1595 domain-containing protein. (341 aa) |
| | ALC57_05330 | Structure-specific endonuclease subunit SLX4. (88 aa) |
| | ALC57_05008 | DNA endonuclease RBBP8. (537 aa) |
| | ALC57_04398 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (567 aa) |
| | ALC57_04099 | DNA mismatch repair protein Mlh1. (737 aa) |
| | ALC57_04076 | DNA polymerase delta subunit 3. (439 aa) |
| | ALC57_03991 | Tumor suppressor p53-binding protein 1. (1415 aa) |
| | ALC57_03914 | DNA polymerase epsilon subunit 3. (131 aa) |
| | ALC57_03924 | Crossover junction endonuclease MUS81. (434 aa) |
| | ALC57_03994 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (562 aa) |
| | ALC57_03229 | DNA repair protein XRCC2. (268 aa) |
| | ALC57_03171 | Replication factor C subunit 1. (1036 aa) |
| | ALC57_02725 | Chromosome transmission fidelity protein 18 like protein. (883 aa) |
| | ALC57_02915 | DNA replication complex GINS protein PSF1. (195 aa) |
| | ALC57_00810 | DNA repair endonuclease XPF. (286 aa) |
| | ALC57_00779 | Breast cancer type 1 susceptibility protein like protein. (1876 aa) |
| | ALC57_00695 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1109 aa) |
| | ALC57_00590 | Crossover junction endonuclease EME1. (454 aa) |
| | ALC57_00220 | ATP-dependent DNA helicase Q4. (1522 aa) |
| | ALC57_00148 | Exonuclease 3'-5' domain-containing protein 2. (291 aa) |
| | ALC57_17474 | Uncharacterized protein. (586 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa) |
| | ALC57_18955 | Replication protein A 14 kDa subunit. (115 aa) |
| | ALC57_18982 | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). (895 aa) |
| | ALC57_18657 | Piezo-type mechanosensitive ion channel component. (2650 aa) |
| | ALC57_17951 | Putative DNA primase large subunit. (416 aa) |
| | ALC57_17775 | Serine/threonine-protein kinase atr; Belongs to the PI3/PI4-kinase family. (2353 aa) |
| | ALC57_17767 | ATPase family AAA domain-containing protein 5. (1154 aa) |
| | ALC57_17816 | Replication factor C subunit 3. (354 aa) |
| | ALC57_17517 | DNA replication licensing factor Mcm6; Belongs to the MCM family. (763 aa) |
| | ALC57_17122 | Cell cycle checkpoint protein RAD1. (490 aa) |
| | ALC57_17162 | DNA polymerase epsilon subunit 4. (123 aa) |
| | ALC57_16714 | Double-strand break repair protein MRE11A. (540 aa) |
| | ALC57_16206 | Fanconi anemia group M protein. (1358 aa) |
| | ALC57_16040 | Exonuclease 1. (621 aa) |
| | ALC57_15224 | Replication protein A 32 kDa subunit. (241 aa) |
| | ALC57_15226 | Uncharacterized protein. (261 aa) |
| | ALC57_14882 | DNA replication factor Cdt1. (707 aa) |
| | ALC57_14975 | DNA polymerase delta small subunit. (458 aa) |
| | ALC57_14379 | Protein MCM10 like protein. (735 aa) |
| | ALC57_13917 | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2244 aa) |
| | ALC57_13639 | DNA polymerase. (1781 aa) |
| | ALC57_13664 | TNFR-Cys domain-containing protein. (332 aa) |
| | ALC57_13736 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (191 aa) |
| | ALC57_13923 | DNA mismatch repair protein Mlh3. (773 aa) |
| | ALC57_13550 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (451 aa) |
| | ALC57_13544 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (950 aa) |
| | ALC57_13119 | Checkpoint protein HUS1. (459 aa) |
| | ALC57_12687 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | ALC57_12436 | WD repeat and HMG-box DNA-binding protein 1. (1394 aa) |
| | ALC57_11321 | DNA replication licensing factor MCM9; Belongs to the MCM family. (634 aa) |
| | ALC57_10839 | Chromosome transmission fidelity protein 8 like protein. (91 aa) |
| | ALC57_10939 | Uncharacterized protein. (490 aa) |
| | ALC57_10372 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (377 aa) |
| | ALC57_10064 | DNA repair and recombination protein RAD54B. (903 aa) |
| | ALC57_10011 | Serine/threonine-protein kinase Chk2. (462 aa) |
| | ALC57_08418 | MutS protein like protein 4. (1022 aa) |
| | ALC57_07711 | Protein chiffon. (1584 aa) |
| | ALC57_07479 | Mismatch repair endonuclease PMS2. (672 aa) |
| | ALC57_07484 | Xylosyltransferase oxt. (919 aa) |
| | ALC57_07034 | DNA polymerase. (1055 aa) |
| | ALC57_07030 | Helicase POLQ-like protein. (965 aa) |
| | ALC57_06689 | DNA repair protein XRCC3. (258 aa) |
| | ALC57_06837 | DNA helicase; Belongs to the MCM family. (881 aa) |
| | ALC57_07001 | DNA replication licensing factor MCM8; Belongs to the MCM family. (689 aa) |
| | ALC57_06628 | E3 ubiquitin-protein ligase RAD18. (658 aa) |
| | ALC57_06245 | DNA repair protein RAD51 like protein 4. (306 aa) |
| | ALC57_06250 | DNA topoisomerase 2-binding protein 1-A. (1319 aa) |
| | ALC57_06255 | Putative nuclear transport factor 2. (186 aa) |
| | ALC57_06937 | DNA excision repair protein ERCC-1. (262 aa) |
| | ALC57_05431 | DNA replication complex GINS protein PSF3. (199 aa) |
| | ALC57_04583 | Fanconi anemia group D2 protein. (1365 aa) |
| | ALC57_04603 | Cell cycle checkpoint protein RAD17. (473 aa) |
| | ALC57_04719 | DNA repair endonuclease XPF. (881 aa) |
| | ALC57_04229 | Exonuclease 3'-5' domain-containing protein 2. (329 aa) |
| | ALC57_04861 | Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (271 aa) |
| | ALC57_03844 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (270 aa) |
| | ALC57_04298 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (970 aa) |
| | ALC57_03797 | DNA primase large subunit. (509 aa) |
| | ALC57_03335 | DNA helicase. (824 aa) |
| | ALC57_03385 | MutS protein like protein 5. (859 aa) |
| | ALC57_03808 | Replication factor C subunit 5. (487 aa) |
| | ALC57_03523 | BRCA1-associated RING domain protein 1. (522 aa) |
| | ALC57_03582 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (667 aa) |
| | ALC57_03519 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (572 aa) |
| | ALC57_03624 | DNA polymerase delta subunit 2. (447 aa) |
| | ALC57_03595 | Replication protein A 70 kDa DNA-binding subunit. (128 aa) |
| | ALC57_03631 | DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (340 aa) |
| | ALC57_02903 | DNA2-like helicase. (1233 aa) |
| | ALC57_02793 | Putative ATP-dependent RNA helicase DDX11. (806 aa) |
| | ALC57_02351 | DNA topoisomerase 3-alpha. (408 aa) |
| | ALC57_02352 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1057 aa) |
| | ALC57_01936 | Tudor domain-containing protein 3. (695 aa) |
| | ALC57_01317 | DNA repair protein RAD52 like protein. (280 aa) |
| | ALC57_01373 | DNA polymerase. (1757 aa) |
| | ALC57_01656 | DNA polymerase eta. (820 aa) |
