node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALC57_06353 | ALC57_08840 | A0A151J922 | A0A151J6R2 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.561 |
ALC57_06353 | ALC57_09716 | A0A151J922 | A0A151J534 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | NEDD8-activating enzyme E1 catalytic subunit. | 0.572 |
ALC57_06353 | ALC57_11422 | A0A151J922 | A0A151J2T0 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.520 |
ALC57_06353 | ALC57_12425 | A0A151J922 | A0A195DRA7 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | SUMO-activating enzyme subunit 1. | 0.454 |
ALC57_06353 | ALC57_14083 | A0A151J922 | A0A151IYU0 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | NEDD8-activating enzyme E1 regulatory subunit. | 0.503 |
ALC57_06353 | ALC57_18582 | A0A151J922 | A0A151IRI2 | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family. | 0.410 |
ALC57_08840 | ALC57_06353 | A0A151J6R2 | A0A151J922 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | 0.561 |
ALC57_08840 | ALC57_09716 | A0A151J6R2 | A0A151J534 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | NEDD8-activating enzyme E1 catalytic subunit. | 0.944 |
ALC57_08840 | ALC57_11029 | A0A151J6R2 | A0A151J306 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | Ubiquitin-like modifier-activating enzyme 5. | 0.863 |
ALC57_08840 | ALC57_11422 | A0A151J6R2 | A0A151J2T0 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.877 |
ALC57_08840 | ALC57_14083 | A0A151J6R2 | A0A151IYU0 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | NEDD8-activating enzyme E1 regulatory subunit. | 0.549 |
ALC57_08840 | ALC57_18582 | A0A151J6R2 | A0A151IRI2 | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family. | 0.539 |
ALC57_09716 | ALC57_06353 | A0A151J534 | A0A151J922 | NEDD8-activating enzyme E1 catalytic subunit. | Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] | 0.572 |
ALC57_09716 | ALC57_08840 | A0A151J534 | A0A151J6R2 | NEDD8-activating enzyme E1 catalytic subunit. | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.944 |
ALC57_09716 | ALC57_11029 | A0A151J534 | A0A151J306 | NEDD8-activating enzyme E1 catalytic subunit. | Ubiquitin-like modifier-activating enzyme 5. | 0.858 |
ALC57_09716 | ALC57_11422 | A0A151J534 | A0A151J2T0 | NEDD8-activating enzyme E1 catalytic subunit. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. | 0.849 |
ALC57_09716 | ALC57_12425 | A0A151J534 | A0A195DRA7 | NEDD8-activating enzyme E1 catalytic subunit. | SUMO-activating enzyme subunit 1. | 0.564 |
ALC57_09716 | ALC57_14083 | A0A151J534 | A0A151IYU0 | NEDD8-activating enzyme E1 catalytic subunit. | NEDD8-activating enzyme E1 regulatory subunit. | 0.999 |
ALC57_11029 | ALC57_08840 | A0A151J306 | A0A151J6R2 | Ubiquitin-like modifier-activating enzyme 5. | Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.863 |
ALC57_11029 | ALC57_09716 | A0A151J306 | A0A151J534 | Ubiquitin-like modifier-activating enzyme 5. | NEDD8-activating enzyme E1 catalytic subunit. | 0.858 |