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| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (168 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (312 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (210 aa) |
| | folD | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa) |
| | TGRD_034 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (354 aa) |
| | TGRD_064 | M16 family peptidase. (407 aa) |
| | TGRD_065 | M16 family peptidase; Belongs to the peptidase M16 family. (407 aa) |
| | TGRD_066 | Hexuronate transporter. (472 aa) |
| | uxaC | Glucuronate isomerase. (468 aa) |
| | TGRD_068 | Putative mannonate dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family. (364 aa) |
| | TGRD_070 | 2-dehydro-3-deoxygluconokinase; KDG kinase. (341 aa) |
| | TGRD_071 | 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase; KHG/KDPG aldolase. (321 aa) |
| | TGRD_116 | Anthranilate synthase anthranilate synthase component. (491 aa) |
| | TGRD_117 | Anthranilate synthase glutamine amidotransferase component. (192 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; IGPS; Belongs to the TrpC family. (258 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (200 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | TGRD_139 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (320 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (416 aa) |
| | TGRD_147 | Glyceraldehyde-3-phosphate dehydrogenase; GAPDH; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | TGRD_158 | Glutamate synthase large subunit GltB glutamine amidotransferase component; Contains domain 1. (363 aa) |
| | TGRD_159 | Glutamate synthase large subunit GltB FMN-binding component; Contains domain 2; Belongs to the glutamate synthase family. (501 aa) |
| | TGRD_160 | 4Fe-4S ferredoxin. (155 aa) |
| | TGRD_162 | Glutamate synthase large subunit GltB uncharacterized component; Contains domain 3. (245 aa) |
| | carA | Carbamoyl-phosphate synthase arginine-specific small chain; Belongs to the CarA family. (380 aa) |
| | TGRD_164 | Rotamase surA-like protein. (351 aa) |
| | TGRD_165 | Carbamoyl-phosphate synthase arginine-specific large chain. (1103 aa) |
| | TGRD_168 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (140 aa) |
| | hisG | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | TGRD_187 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | TGRD_188 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; BCCP. (159 aa) |
| | TGRD_190 | Xaa-Pro aminopeptidase. (350 aa) |
| | aroQ | 3-dehydroquinate synthetase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | aroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (361 aa) |
| | TGRD_245 | 2-oxoglutarate synthase beta subunit. (249 aa) |
| | TGRD_246 | 2-oxoglutarate synthase alpha subunit. (353 aa) |
| | TGRD_247 | 2-oxoglutarate synthase delta subunit. (70 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (454 aa) |
| | TGRD_278 | Pyruvate:ferredoxin oxidoreductase gamma subunit; PFOR. (188 aa) |
| | TGRD_279 | Pyruvate:ferredoxin oxidoreductase delta subunit; PFOR. (103 aa) |
| | TGRD_280 | Pyruvate:ferredoxin oxidoreductase alpha subunit; PFOR. (401 aa) |
| | TGRD_281 | Pyruvate:ferredoxin oxidoreductase beta subunit; PFOR. (311 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (385 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | accA | acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (327 aa) |
| | TGRD_286 | Fructose-bisphosphate aldolase. (331 aa) |
| | TGRD_287 | Oxaloacetate-decarboxylating NAD-malic enzyme. (450 aa) |
| | TGRD_288 | Fumarate hydratase alpha subunit; Fumarase. (279 aa) |
| | TGRD_289 | Fumarate hydratase beta subunit; Fumarase. (173 aa) |
| | TGRD_308 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (320 aa) |
| | TGRD_310 | Dihydroorotate dehydrogenase electron transfer subunit. (281 aa) |
| | TGRD_311 | Glutamate synthase small subunit. (456 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa) |
| | TGRD_313 | Ribose-5-phosphate isomerase B. (149 aa) |
| | TGRD_314 | Transketolase; N-terminal section of transketolase. (274 aa) |
| | TGRD_315 | Transketolase; C-terminal section of transketolase. (315 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | TGRD_321 | 5-formyltetrahydrofolate cyclo-ligase; MTHFS; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (199 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (249 aa) |
| | TGRD_343 | Phosphate acetyltransferase. (333 aa) |
| | TGRD_354 | Putative N-acetyltransferase; Belongs to the acetyltransferase family. (151 aa) |
| | TGRD_355 | 2-oxoglutarate synthase gamma subunit. (190 aa) |
| | TGRD_413 | Glycine cleavage system L protein. (454 aa) |
| | TGRD_415 | Glycine cleavage system T protein; Aminomethyltransferase. (354 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (547 aa) |
| | TGRD_423 | Conserved hypothetical protein; Contains Fe-S-cluster. (350 aa) |
| | purH | Bifunctional purine biosynthesis protein PurH. (518 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (275 aa) |
| | TGRD_450 | Carboxynorspermidine decarboxylase. (368 aa) |
| | TGRD_451 | Putative saccharopine dehydrogenase. (405 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | TGRD_453 | 3-isopropylmalate dehydrogenase. (353 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa) |
| | TGRD_471 | Lipoate-protein ligase A-like protein. (218 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (274 aa) |
| | TGRD_493 | N-(5'-phosphoribosyl) anthranilate isomerase; PRAI; Belongs to the TrpF family. (185 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (129 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (260 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (244 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (210 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (419 aa) |
| | TGRD_513 | Ribosomal-protein-alanine N-acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (148 aa) |
| | TGRD_522 | NAD-dependent Fe-hydrogenase catalytic component. (667 aa) |
| | TGRD_523 | NAD-dependent Fe-hydrogenase 51kDa NADH dehydrogenase component. (623 aa) |
| | TGRD_524 | NAD-dependent Fe-hydrogenase 24kDa NADH dehydrogenase component. (157 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | TGRD_536 | Aspartate aminotransferase; Transaminase A, ASPAT. (395 aa) |
| | TGRD_543 | Prephenate dehydrogenase; PDH. (279 aa) |
| | TGRD_544 | DHAP synthase. (340 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (377 aa) |
| | TGRD_546 | Chorismate mutase/prephenate dehydratase. (359 aa) |
| | TGRD_556 | 3-oxoacyl-[acyl-carrier-protein] reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (233 aa) |
| | TGRD_557 | 3-oxoacyl-[acyl-carrier-protein] synthase II; KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (365 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa) |
| | argD | Acetylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (398 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (249 aa) |
| | TGRD_569 | Homoserine dehydrogenase; HSD. (427 aa) |
| | pfp | Pyrophosphate-fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (561 aa) |
| | TGRD_584 | Homocysteine S-methyltransferase. (801 aa) |
| | TGRD_590 | Conserved hypothetical protein; Contains ferredoxin domain. (378 aa) |
| | TGRD_592 | Conserved hypothetical protein. (393 aa) |
| | TGRD_595 | Aldehyde-alcohol dehydrogenase; ADH/ACDH; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (881 aa) |
| | TGRD_596 | Electron transfer flavoprotein alpha subunit; alpha-ETF. (409 aa) |
| | TGRD_597 | Electron transfer flavoprotein beta subunit; beta-ETF. (262 aa) |
| | TGRD_598 | FAD-dependent acyl-CoA dehydrogenase. (389 aa) |
| | TGRD_600 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | acpP | Acyl carrier protein AcpP; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (79 aa) |
| | TGRD_602 | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | TGRD_603 | S-malonyltransferase. (309 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (328 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (338 aa) |
| | fabZ | 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (159 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (431 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (393 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa) |
| | TGRD_639 | Putative class I and II aminotransferase. (388 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (257 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (291 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (410 aa) |
| | argH | Argininosuccinate lyase. (442 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (291 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (430 aa) |
| | TGRD_664 | DHAP synthase. (340 aa) |
| | TGRD_665 | Histidinol-phosphate aminotransferase. (377 aa) |
| | TGRD_666 | Chorismate mutase/prephenate dehydratase. (359 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa) |
| | argJ | Glutamate N-acetyltransferase/amino-acid N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (400 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (339 aa) |
| | TGRD_682 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | TGRD_685 | Acetolactate synthase small subunit; AHAS. (157 aa) |
| | TGRD_686 | Acetolactate synthase large subunit; AHAS. (578 aa) |
| | ilvD | Dihydroxy-acid dehydratase; DAD; Belongs to the IlvD/Edd family. (549 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa) |
| | TGRD_700 | Pyruvate kinase barrel domain; Belongs to the pyruvate kinase family. (335 aa) |
| | TGRD_706 | 5,10-methylenetetrahydrofolate reductase; MTHFR; Belongs to the methylenetetrahydrofolate reductase family. (287 aa) |
| | TGRD_707 | Hypothetical protein. (79 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa) |
| | gcvPA | Glycine cleavage system P protein subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (443 aa) |
| | gcvPB | Glycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (478 aa) |
| | TGRD_731 | Putative (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (529 aa) |
| | TGRD_732 | Aspartate kinase; Belongs to the aspartokinase family. (417 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa) |
| | TGRD_736 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; AIRS. (320 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (194 aa) |
| | TGRD_742 | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). (214 aa) |
| | pyrD | Dihydroorotate dehydrogenase catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (306 aa) |
| | TGRD_746 | Dihydroorotate dehydrogenase electron transfer subunit. (291 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | pyrR | Uracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (177 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (177 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (426 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (261 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to as [...] (809 aa) |
| | TGRD_754 | Phosphoribosylformylglycinamidine synthase II PurS. (178 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (292 aa) |
