STRINGSTRING
def def fmt fmt folD folD TGRD_158 TGRD_158 TGRD_159 TGRD_159 TGRD_160 TGRD_160 TGRD_162 TGRD_162 carA carA TGRD_164 TGRD_164 TGRD_165 TGRD_165 purF purF TGRD_310 TGRD_310 TGRD_311 TGRD_311 TGRD_321 TGRD_321 TGRD_413 TGRD_413 TGRD_415 TGRD_415 purH purH lipA lipA TGRD_471 TGRD_471 TGRD_584 TGRD_584 ahcY ahcY metK metK glyA glyA TGRD_706 TGRD_706 TGRD_707 TGRD_707 gcvH gcvH gcvPA gcvPA gcvPB gcvPB TGRD_736 TGRD_736 purN purN purM purM pyrE pyrE TGRD_742 TGRD_742 pyrD pyrD TGRD_746 TGRD_746 pyrC pyrC pyrB pyrB pyrR pyrR purE purE purD purD purQ purQ purL purL TGRD_754 TGRD_754 purC purC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (168 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (312 aa)
folDBifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (296 aa)
TGRD_158Glutamate synthase large subunit GltB glutamine amidotransferase component; Contains domain 1. (363 aa)
TGRD_159Glutamate synthase large subunit GltB FMN-binding component; Contains domain 2; Belongs to the glutamate synthase family. (501 aa)
TGRD_1604Fe-4S ferredoxin. (155 aa)
TGRD_162Glutamate synthase large subunit GltB uncharacterized component; Contains domain 3. (245 aa)
carACarbamoyl-phosphate synthase arginine-specific small chain; Belongs to the CarA family. (380 aa)
TGRD_164Rotamase surA-like protein. (351 aa)
TGRD_165Carbamoyl-phosphate synthase arginine-specific large chain. (1103 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (454 aa)
TGRD_310Dihydroorotate dehydrogenase electron transfer subunit. (281 aa)
TGRD_311Glutamate synthase small subunit. (456 aa)
TGRD_3215-formyltetrahydrofolate cyclo-ligase; MTHFS; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (199 aa)
TGRD_413Glycine cleavage system L protein. (454 aa)
TGRD_415Glycine cleavage system T protein; Aminomethyltransferase. (354 aa)
purHBifunctional purine biosynthesis protein PurH. (518 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (275 aa)
TGRD_471Lipoate-protein ligase A-like protein. (218 aa)
TGRD_584Homocysteine S-methyltransferase. (801 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (431 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (393 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (416 aa)
TGRD_7065,10-methylenetetrahydrofolate reductase; MTHFR; Belongs to the methylenetetrahydrofolate reductase family. (287 aa)
TGRD_707Hypothetical protein. (79 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa)
gcvPAGlycine cleavage system P protein subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (443 aa)
gcvPBGlycine cleavage system P protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (478 aa)
TGRD_736Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; AIRS. (320 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (194 aa)
TGRD_742Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). (214 aa)
pyrDDihydroorotate dehydrogenase catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (306 aa)
TGRD_746Dihydroorotate dehydrogenase electron transfer subunit. (291 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa)
pyrRUracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (177 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (177 aa)
purDPhosphoribosylamine-glycine ligase; Belongs to the GARS family. (426 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (261 aa)
purLPhosphoribosylformylglycinamidine synthase II PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to as [...] (809 aa)
TGRD_754Phosphoribosylformylglycinamidine synthase II PurS. (178 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (292 aa)
Your Current Organism:
uncultured Termite group 1 bacterium phylotype
NCBI taxonomy Id: 471821
Other names: u. Termite group 1 bacterium phylotype Rs-D17, uncultured Termite group 1 bacterium phylotype Rs-D17
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