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| | ACU95416.1 | N-dimethylarginine dimethylaminohydrolase; PFAM: Amidinotransferase. (270 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (229 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (512 aa) |
| | ACU98718.1 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; PFAM: Aminotransferase class IV. (282 aa) |
| | ACU98715.1 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. (279 aa) |
| | ACU98696.1 | Tryptophanase; PFAM: Beta-eliminating lyase. (460 aa) |
| | ACU98680.1 | Homocysteine/selenocysteine methylase (S-methylmethionine-dependent); PFAM: Homocysteine S-methyltransferase. (295 aa) |
| | ACU98640.1 | PFAM: Prephenate dehydrogenase. (322 aa) |
| | ACU98639.1 | Amidohydrolase; PFAM: Peptidase family M20/M25/M40; TIGRFAM: amidohydrolase. (410 aa) |
| | ACU98621.1 | Methionine synthase II (cobalamin-independent); PFAM: Cobalamin-independent synthase, Catalytic domain. (373 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (594 aa) |
| | ACU98591.1 | PFAM: Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (420 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa) |
| | ACU98549.1 | TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like. (280 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (165 aa) |
| | cysS | PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (459 aa) |
| | ACU98432.1 | Glutamine--fructose-6-phosphate transaminase; PFAM: SIS domain. (359 aa) |
| | serC | Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (376 aa) |
| | ACU98328.1 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase family. (403 aa) |
| | ACU98323.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, central domain; Belongs to the TPP enzyme family. (596 aa) |
| | ACU98302.1 | PFAM: Asparagine synthase. (512 aa) |
| | ACU98301.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, central domain; Belongs to the TPP enzyme family. (556 aa) |
| | argJ-2 | N-acetylglutamate synthase /glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (385 aa) |
| | ACU98269.1 | PFAM: Aminomethyltransferase folate-binding domain; Belongs to the GcvT family. (450 aa) |
| | ACU98259.1 | Dihydrofolate reductase; PFAM: RibD C-terminal domain. (194 aa) |
| | ACU98231.1 | PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (341 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (595 aa) |
| | ACU98183.1 | Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain. (347 aa) |
| | ACU98162.1 | Cystathionine beta-synthase; PFAM: Pyridoxal-phosphate dependent enzyme; CBS domain pair; TIGRFAM: cystathionine beta-synthase. (457 aa) |
| | ACU98159.1 | Cystathionine gamma-lyase; PFAM: Cys/Met metabolism PLP-dependent enzyme. (387 aa) |
| | ACU98157.1 | L-threonine ammonia-lyase; PFAM: ACT domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine dehydratase, medium form. (401 aa) |
| | ACU98156.1 | PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase. (394 aa) |
| | ACU97998.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (519 aa) |
| | ACU97994.1 | PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (419 aa) |
| | ACU95534.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (378 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (514 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | ACU95643.1 | Amidohydrolase; PFAM: Peptidase family M20/M25/M40; TIGRFAM: amidohydrolase. (426 aa) |
| | ACU95668.1 | PFAM: Inositol monophosphatase family; TIGRFAM: histidinol-phosphate phosphatase HisN, inositol monophosphatase family. (270 aa) |
| | dapD | Tetrahydrodipicolinate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (328 aa) |
| | ACU95700.1 | PFAM: Peptidase family M20/M25/M40; TIGRFAM: succinyl-diaminopimelate desuccinylase. (358 aa) |
| | ACU95746.1 | Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis; PFAM: ThiF family; MoeZ/MoeB domain; Rhodanese-like domain. (398 aa) |
| | ACU95747.1 | TIGRFAM: conserved hypothetical protein TIGR02569, Actinobacterial. (266 aa) |
| | ACU95771.1 | PFAM: homogentisate 1,2-dioxygenase; TIGRFAM: homogentisate 1,2-dioxygenase. (399 aa) |
| | ACU95772.1 | Hypothetical protein. (292 aa) |
| | ACU95784.1 | D-mannonate dehydratase; PFAM: Mandelate racemase / muconate lactonizing enzyme, N-terminal domain; Mandelate racemase / muconate lactonizing enzyme, C-terminal domain. (402 aa) |
| | ACU95812.1 | PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. (447 aa) |
| | ACU95813.1 | GMP synthase family protein; PFAM: Glutamine amidotransferase class-I. (261 aa) |
| | ACU95816.1 | PFAM: Glutamine synthetase, beta-Grasp domain; Glutamine synthetase, catalytic domain; TIGRFAM: glutamine synthetase, type I. (474 aa) |
| | ilvD | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (571 aa) |
| | cobB | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) /cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (487 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (333 aa) |
| | ACU95927.1 | PFAM: Cobalamin-independent synthase, Catalytic domain. (362 aa) |
| | ilvD-2 | PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (614 aa) |
| | ACU95947.1 | Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Thiamine pyrophosphate enzyme, central domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type. (620 aa) |
| | ACU95948.1 | PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. (168 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | ACU95951.1 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (531 aa) |
| | ACU95955.1 | PFAM: Isocitrate/isopropylmalate dehydrogenase. (342 aa) |
| | ACU95958.1 | 2-isopropylmalate synthase; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (570 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (493 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | ACU95984.1 | Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase; PFAM: Arginase family; Belongs to the arginase family. (277 aa) |
| | ACU96029.1 | Pro-Hyp dipeptidase; PFAM: Amidohydrolase family. (354 aa) |
| | proS | prolyl-tRNA synthetase, family II; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and i [...] (586 aa) |
| | ACU96112.1 | PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II. (367 aa) |
| | ACU96118.1 | PFAM: Glutamine amidotransferases class-II; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (642 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (444 aa) |
| | hisC | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (374 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | ACU96155.1 | Threonine dehydratase; PFAM: Pyridoxal-phosphate dependent enzyme. (330 aa) |
| | ACU96197.1 | PFAM: Iron-binding zinc finger CDGSH type. (71 aa) |
| | ACU96221.1 | PFAM: Aminomethyltransferase folate-binding domain; Belongs to the GcvT family. (466 aa) |
| | ACU96222.1 | PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (292 aa) |
| | folD-2 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | ACU96232.1 | PFAM: Bacterial NAD-glutamate dehydrogenase. (1643 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (882 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa) |
| | ACU96310.1 | L-threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (420 aa) |
| | ACU96342.1 | Theronine dehydrogenase-like Zn-dependent dehydrogenase; PFAM: Zinc-binding dehydrogenase; Alcohol dehydrogenase GroES-like domain. (394 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (969 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (370 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (463 aa) |
| | ACU96420.1 | O-acetylhomoserine sulfhydrolase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. (432 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (377 aa) |
| | ACU96482.1 | PFAM: Isocitrate/isopropylmalate dehydrogenase. (356 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (256 aa) |
| | thrS | threonyl-tRNA synthetase /Ser-tRNA(Thr) hydrolase; PFAM: tRNA synthetase class II core domain (G, H, P, S and T); Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (692 aa) |
| | ACU96550.1 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; PFAM: Aminotransferase class IV. (273 aa) |
| | ACU96555.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, central domain; Belongs to the TPP enzyme family. (586 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (888 aa) |
| | ACU96565.1 | PFAM: Shikimate dehydrogenase substrate binding domain; Shikimate / quinate 5-dehydrogenase; TIGRFAM: shikimate 5-dehydrogenase; shikimate-5-dehydrogenase, fungal AROM-type; Belongs to the shikimate dehydrogenase family. (287 aa) |
| | ACU96567.1 | Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain. (314 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (400 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (180 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (368 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (143 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | ACU96592.1 | Hypothetical protein. (163 aa) |
| | carA | PFAM: Glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain, CPSase domain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (378 aa) |
| | carB | PFAM: MGS-like domain; ATP-grasp domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; carbamoyl-phosphate synthase, large subunit. (1111 aa) |
| | ACU96661.1 | Uncharacterized conserved protein; PFAM: Prokaryotic protein of unknown function (DUF849). (295 aa) |
| | lysS | lysyl-tRNA synthetase (class II); PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; TIGRFAM: lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Belongs to the class-II aminoacyl-tRNA synthetase family. (499 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (333 aa) |
| | ACU96738.1 | Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40. (439 aa) |
| | ACU96791.1 | Sulfite reductase, beta subunit (hemoprotein); PFAM: Nitrite/Sulfite reductase ferredoxin-like half domain. (292 aa) |
| | cobQ | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (498 aa) |
| | ACU96868.1 | PFAM: Tryptophan 2,3-dioxygenase. (237 aa) |
| | ACU96883.1 | Predicted metal-dependent hydrolase; PFAM: Putative cyclase. (273 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | ACU96905.1 | PFAM: FAD dependent oxidoreductase; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form; Belongs to the GcvT family. (925 aa) |
| | ACU96906.1 | PFAM: Sarcosine oxidase, gamma subunit family; TIGRFAM: sarcosine oxidase, gamma subunit family, heterotetrameric form. (206 aa) |
| | ACU96912.1 | Hypothetical protein. (289 aa) |
| | ACU96913.1 | PFAM: homogentisate 1,2-dioxygenase; TIGRFAM: homogentisate 1,2-dioxygenase. (406 aa) |
| | ACU96931.1 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme. (401 aa) |
| | ACU96984.1 | Periplasmic component of the Tol biopolymer transport system; PFAM: Amidohydrolase family; WD40-like Beta Propeller Repeat; Dipeptidyl peptidase IV (DPP IV) N-terminal region. (1059 aa) |
| | ACU97011.1 | Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40. (434 aa) |
| | ACU97083.1 | PFAM: Cupin domain; TIGRFAM: gentisate 1,2-dioxygenase. (372 aa) |
| | ACU97157.1 | Uncharacterized protein involved in cysteine biosynthesis; PFAM: Protein of unknown function (DUF540). (253 aa) |
| | ACU97161.1 | Ethanolamine ammonia-lyase heavy chain; PFAM: Ethanolamine ammonia lyase large subunit (EutB). (460 aa) |
| | ACU97162.1 | PFAM: Ethanolamine ammonia-lyase light chain (EutC); Belongs to the EutC family. (280 aa) |
| | ACU97163.1 | Amidohydrolase, imidazolonepropionase; PFAM: Amidohydrolase family. (447 aa) |
| | ACU97189.1 | L-lysine 2,3-aminomutase; PFAM: Radical SAM superfamily; TIGRFAM: KamA family protein. (459 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (287 aa) |
| | hisE | PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-ATP pyrophosphohydrolase. (96 aa) |
| | egtD | Probable methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (324 aa) |
| | egtC | Conserved hypothetical protein TIGR03442; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (265 aa) |
| | ACU97257.1 | PFAM: Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (393 aa) |
| | ACU97274.1 | PLP-dependent enzyme, glutamate decarboxylase; PFAM: Aminotransferase class-V. (483 aa) |
| | ACU97287.1 | Pyruvate dehydrogenase (cytochrome); PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, central domain; Belongs to the TPP enzyme family. (578 aa) |
| | ACU97315.1 | Hypothetical protein. (234 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (423 aa) |
| | hisS | PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase. (432 aa) |
| | ACU97393.1 | PFAM: Aminotransferase class-III; TIGRFAM: ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (141 aa) |
| | ACU97456.1 | PFAM: Pyridoxal-dependent decarboxylase, pyridoxal binding domain; Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (389 aa) |
| | ACU97474.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (374 aa) |
| | ACU97512.1 | N-acetylglutamate synthase; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (189 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (566 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (444 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (424 aa) |
| | argH | PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (465 aa) |
| | argG | PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (171 aa) |
| | arcB | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (309 aa) |
| | argD | PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (308 aa) |
| | argJ | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; PFAM: Putative tRNA binding domain; Ferredoxin-fold anticodon binding domain; tRNA synthetase B5 domain; B3/4 domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (838 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (355 aa) |
| | ACU97598.1 | PFAM: Acetyltransferase (GNAT) family. (153 aa) |
| | ACU97623.1 | Dihydrofolate reductase; PFAM: RibD C-terminal domain. (208 aa) |
| | ACU97684.1 | PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family. (302 aa) |
| | ACU97686.1 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1184 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1060 aa) |
| | ACU97731.1 | Rhodanese-related sulfurtransferase; PFAM: Rhodanese-like domain. (280 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (622 aa) |
| | ACU97782.1 | PFAM: Class-II DAHP synthetase family; TIGRFAM: 3-deoxy-7-phosphoheptulonate synthase, class II. (467 aa) |
| | ACU97784.1 | Glutamate synthase (NADH) small subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; TIGRFAM: glutamate synthases, NADH/NADPH, small subunit. (501 aa) |
| | ACU97785.1 | Glutamate synthase (NADH) large subunit; PFAM: GXGXG motif; Glutamate synthase central domain; Conserved region in glutamate synthase; Glutamine amidotransferases class-II. (1527 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (517 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (119 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | PFAM: Histidine biosynthesis protein; TIGRFAM: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase/N-(5'phosphoribosyl)anthranilate isomerase; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (260 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | ACU97804.1 | Valine dehydrogenase (NAD); PFAM: Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (355 aa) |
| | ACU97842.1 | TIGRFAM: gamma-glutamyl phosphate reductase. (413 aa) |
| | ACU97894.1 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthases. (316 aa) |
| | ACU97895.1 | Molybdopterin synthase subunit MoaD; PFAM: ThiS family. (92 aa) |
| | ACU97896.1 | Predicted metal-dependent protease of the PAD1/JAB1 superfamily; PFAM: Mov34/MPN/PAD-1 family. (152 aa) |
| | ACU97908.1 | Phosphoserine phosphatase; PFAM: ACT domain; haloacid dehalogenase-like hydrolase; TIGRFAM: Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like; phosphoserine phosphatase SerB. (409 aa) |
| | ACU97957.1 | Glycine cleavage system T protein (aminomethyltransferase); PFAM: Aminomethyltransferase folate-binding domain; Belongs to the GcvT family. (346 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (291 aa) |
| | ACU97973.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (364 aa) |
| | ACU97974.1 | PFAM: Homoserine dehydrogenase; ACT domain; Homoserine dehydrogenase, NAD binding domain. (435 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (479 aa) |
| | argS | PFAM: tRNA synthetases class I (R); DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; TIGRFAM: arginyl-tRNA synthetase. (551 aa) |
| | ACU97986.1 | Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, central domain; Belongs to the TPP enzyme family. (553 aa) |
| | ACU97992.1 | Tartrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase. (363 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (620 aa) |
| | ACU98752.1 | Threonine aldolase; PFAM: Beta-eliminating lyase. (351 aa) |
| | ACU95384.1 | Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme. (354 aa) |
| | ACU95361.1 | PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like. (323 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | ACU95355.1 | PFAM: Proline dehydrogenase. (308 aa) |
| | ACU95323.1 | PFAM: Aminotransferase class I and II. (387 aa) |
| | ACU95321.1 | Predicted membrane protein; PFAM: Uncharacterized BCR, YitT family COG1284. (209 aa) |
| | ACU95293.1 | Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferases class-II; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (512 aa) |
| | pat | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (351 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | ACU95207.1 | PFAM: Prephenate dehydratase; ACT domain. (301 aa) |
| | ACU95191.1 | Hypothetical protein. (284 aa) |
| | arcA | Arginine deiminase; PFAM: Amidinotransferase; TIGRFAM: arginine deiminase. (418 aa) |
| | ACU95141.1 | Predicted amino acid aldolase or racemase; PFAM: Alanine racemase, N-terminal domain. (393 aa) |
| | ACU95125.1 | Anthranilate synthase, component II; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (213 aa) |
| | leuS | PFAM: tRNA synthetases class I (M); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; Belongs to the class-I aminoacyl-tRNA synthetase family. (949 aa) |
| | ACU98848.1 | L-asparaginase/GlutRNAGln amidotransferase subunit D; PFAM: Asparaginase. (337 aa) |
| | ACU98827.1 | Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase; PFAM: Peptidase family M20/M25/M40. (475 aa) |
