(90 nodes) Intrinsic apoptotic signaling pathway network (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSNMLP00000003313	Zgc:73226. (189 aa)
	ENSNMLP00000003255	annotation not available (70 aa)
	ENSNMLP00000002416	annotation not available (77 aa)
	ENSNMLP00000002267	annotation not available (203 aa)
	ENSNMLP00000001539	annotation not available (349 aa)
	ENSNMLP00000001425	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (728 aa)
	ENSNMLP00000003603	PRA1 domain family, member 2. (187 aa)
	ENSNMLP00000004913	Caspase 2, apoptosis-related cysteine peptidase. (453 aa)
	ENSNMLP00000005040	Sirtuin 1. (659 aa)
	ENSNMLP00000006159	Caspase 9, apoptosis-related cysteine peptidase. (439 aa)
	ENSNMLP00000006257	ADP-ribosylation factor-like 6 interacting protein 5a. (180 aa)
	ENSNMLP00000006480	annotation not available (977 aa)
	ENSNMLP00000006764	annotation not available (177 aa)
	ENSNMLP00000006769	annotation not available (118 aa)
	ENSNMLP00000007215	BCL2 like 1. (196 aa)
	ENSNMLP00000007992	annotation not available (232 aa)
	ENSNMLP00000008804	annotation not available (143 aa)
	ENSNMLP00000008853	annotation not available (201 aa)
	ENSNMLP00000008867	annotation not available (151 aa)
	ENSNMLP00000008905	annotation not available (209 aa)
	ENSNMLP00000009241	annotation not available (229 aa)
	ENSNMLP00000009249	annotation not available (192 aa)
	ENSNMLP00000010381	Ubiquitin specific peptidase 47. (1361 aa)
	ENSNMLP00000010749	Tumor necrosis factor receptor superfamily, member 1B. (442 aa)
	ENSNMLP00000011781	BCL2 interacting protein 3 like b. (135 aa)
	ENSNMLP00000011945	MCL1 apoptosis regulator, BCL2 family member b. (273 aa)
	ENSNMLP00000012520	Folliculin. (553 aa)
	ENSNMLP00000012559	Pancreatic and duodenal homeobox 1. (247 aa)
	ENSNMLP00000013225	Si:dkey-63b1.1. (353 aa)
	ENSNMLP00000013604	annotation not available (232 aa)
	ENSNMLP00000014673	Pleckstrin homology-like domain, family A, member 3. (125 aa)
	ENSNMLP00000015253	Zgc:153993. (181 aa)
	ENSNMLP00000015322	Zinc finger protein 622. (447 aa)
	ENSNMLP00000016736	DNA-damage-inducible transcript 3. (284 aa)
	ENSNMLP00000017315	annotation not available (69 aa)
	ENSNMLP00000017325	Cell death-inducing p53 target 1. (194 aa)
	ENSNMLP00000017486	annotation not available (166 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (874 aa)
	ENSNMLP00000019834	Ribosomal protein S19. (167 aa)
	ENSNMLP00000020526	BCL2 family apoptosis regulator BOK b. (213 aa)
	ENSNMLP00000020665	Diablo, IAP-binding mitochondrial protein a. (248 aa)
	ENSNMLP00000021130	annotation not available (867 aa)
	ENSNMLP00000021255	Endoplasmic reticulum to nucleus signaling 1. (1080 aa)
	ENSNMLP00000021935	Tumor protein p53. (352 aa)
	ENSNMLP00000022406	BCL2 family apoptosis regulator BOK a. (216 aa)
	ENSNMLP00000022828	BCL2 interacting protein 3. (193 aa)
	ENSNMLP00000022926	Caspase 6, apoptosis-related cysteine peptidase a. (330 aa)
	ENSNMLP00000023329	Apoptosis inducing factor mitochondrion associated 1. (723 aa)
	ENSNMLP00000023393	annotation not available (118 aa)
	ENSNMLP00000023572	annotation not available (194 aa)
	ENSNMLP00000025236	Im:7152348. (136 aa)
	ENSNMLP00000025931	Serine/threonine kinase 11. (426 aa)
	ENSNMLP00000027197	Transmembrane protein 117. (537 aa)
	ENSNMLP00000027262	Tumor protein p63. (634 aa)
	ENSNMLP00000027991	mutS homolog 2 (E. coli). (935 aa)
	ENSNMLP00000029050	annotation not available (203 aa)
	ENSNMLP00000029542	annotation not available (657 aa)
	ENSNMLP00000030072	annotation not available (104 aa)
	ENSNMLP00000030511	annotation not available (573 aa)
	ENSNMLP00000030652	Cytochrome P450, family 1, subfamily C, polypeptide 1. (521 aa)
	ENSNMLP00000030655	Cytochrome P450, family 1, subfamily C, polypeptide 2. (524 aa)
	ENSNMLP00000030942	SNW domain containing 1. (555 aa)
	ENSNMLP00000031973	Tumor necrosis factor receptor superfamily, member 19. (286 aa)
	ENSNMLP00000032713	annotation not available (232 aa)
	ENSNMLP00000033154	BCL2 associated agonist of cell death b. (148 aa)
	ENSNMLP00000033442	annotation not available (90 aa)
	BDKRB2	Bradykinin receptor B2. (365 aa)
	ENSNMLP00000034676	annotation not available (165 aa)
	ENSNMLP00000034807	Tumor necrosis factor receptor superfamily, member 1a. (362 aa)
	ENSNMLP00000037014	annotation not available (100 aa)
	ENSNMLP00000037015	annotation not available (202 aa)
	ENSNMLP00000037216	BCL2 apoptosis regulator b. (210 aa)
	ENSNMLP00000037802	Nuclear protein 1b. (74 aa)
	ENSNMLP00000037888	Tumor protein p73. (609 aa)
	ENSNMLP00000038183	annotation not available (638 aa)
	ENSNMLP00000038184	annotation not available (89 aa)
	ENSNMLP00000038186	annotation not available (120 aa)
	ENSNMLP00000038821	Cytochrome P450, family 1, subfamily B, polypeptide 1. (558 aa)
	ENSNMLP00000039389	annotation not available (206 aa)
	ENSNMLP00000039578	annotation not available (170 aa)
	ENSNMLP00000040411	annotation not available (131 aa)
	ENSNMLP00000040956	ADP-ribosylation factor-like 6 interacting protein 5b. (188 aa)
	ENSNMLP00000041074	BCL2 associated X, apoptosis regulator a. (140 aa)
	ENSNMLP00000041163	Influenza virus NS1A binding protein a. (639 aa)
	ENSNMLP00000041487	annotation not available (331 aa)
	ENSNMLP00000042529	BCL2 like 10. (187 aa)
	ENSNMLP00000043176	SKI-like proto-oncogene a. (757 aa)
	ENSNMLP00000045077	annotation not available (924 aa)
	ENSNMLP00000000919	annotation not available (156 aa)
	ENSNMLP00000000002	annotation not available (313 aa)

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ENSNMLP00000000002	ENSNMLP00000016736	annotation not available	DNA-damage-inducible transcript 3.	0.959
ENSNMLP00000000002	ENSNMLP00000033442	annotation not available	annotation not available	0.979
ENSNMLP00000001425	ENSNMLP00000001539	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	annotation not available	0.930
ENSNMLP00000001425	ENSNMLP00000006480	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	annotation not available	0.985
ENSNMLP00000001425	ENSNMLP00000021935	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Tumor protein p53.	0.487
ENSNMLP00000001425	ENSNMLP00000025931	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Serine/threonine kinase 11.	0.420
ENSNMLP00000001425	ENSNMLP00000027262	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Tumor protein p63.	0.487
ENSNMLP00000001425	ENSNMLP00000027991	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	mutS homolog 2 (E. coli).	0.997
ENSNMLP00000001425	ENSNMLP00000029542	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	annotation not available	0.528
ENSNMLP00000001425	ENSNMLP00000030511	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	annotation not available	0.528
ENSNMLP00000001425	ENSNMLP00000037888	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Tumor protein p73.	0.487
ENSNMLP00000001425	ENSNMLP00000041487	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	annotation not available	0.998
ENSNMLP00000001539	ENSNMLP00000001425	annotation not available	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.930
ENSNMLP00000001539	ENSNMLP00000006480	annotation not available	annotation not available	0.994
ENSNMLP00000001539	ENSNMLP00000021935	annotation not available	Tumor protein p53.	0.751
ENSNMLP00000001539	ENSNMLP00000025931	annotation not available	Serine/threonine kinase 11.	0.529
ENSNMLP00000001539	ENSNMLP00000027262	annotation not available	Tumor protein p63.	0.751
ENSNMLP00000001539	ENSNMLP00000027991	annotation not available	mutS homolog 2 (E. coli).	0.936
ENSNMLP00000001539	ENSNMLP00000029542	annotation not available	annotation not available	0.759
ENSNMLP00000001539	ENSNMLP00000030511	annotation not available	annotation not available	0.821