(60 nodes) Hedgehog signaling pathway network (Neogobius melanostomus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSNMLP00000022129	annotation not available (167 aa)
	ENSNMLP00000043865	Speckle type BTB/POZ protein like b. (393 aa)
	ENSNMLP00000043878	SMAD specific E3 ubiquitin protein ligase 2. (759 aa)
	ENSNMLP00000044368	annotation not available (269 aa)
	ENSNMLP00000024265	Patched 1. (1227 aa)
	ENSNMLP00000024240	annotation not available (411 aa)
	ENSNMLP00000022488	Casein kinase 1, gamma 1. (460 aa)
	MOSMO	Modulator of smoothened. (145 aa)
	ENSNMLP00000043317	Casein kinase 1, gamma 2b. (441 aa)
	ENSNMLP00000019398	Attractin-like 1b. (1348 aa)
	ENSNMLP00000017332	Mahogunin, ring finger 1b. (549 aa)
	ENSNMLP00000016152	annotation not available (294 aa)
	ENSNMLP00000016066	annotation not available (1222 aa)
	ENSNMLP00000015878	Cullin 1a. (776 aa)
	ENSNMLP00000014810	Limb development membrane protein 1-like. (485 aa)
	ENSNMLP00000014619	GLI family zinc finger 2a. (1403 aa)
	ENSNMLP00000014291	Desert hedgehog signaling molecule. (446 aa)
	CSNK1G2	Casein kinase 1 gamma 2. (426 aa)
	SPOP	Speckle type BTB/POZ protein. (403 aa)
	ENSNMLP00000012691	Suppressor of fused homolog (Drosophila). (475 aa)
	ENSNMLP00000012094	annotation not available (406 aa)
	ENSNMLP00000012077	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b. (234 aa)
	ENSNMLP00000011944	Cyclin Dx. (315 aa)
	ENSNMLP00000011856	Cyclin D2, a. (290 aa)
	ENSNMLP00000009804	Kinesin family member 3A. (714 aa)
	ENSNMLP00000008650	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b. (234 aa)
	ENSNMLP00000007186	annotation not available (721 aa)
	ENSNMLP00000006239	Casein kinase 1, alpha 1. (341 aa)
	ENSNMLP00000005624	Casein kinase 1, epsilon. (426 aa)
	ENSNMLP00000003816	annotation not available (241 aa)
	ENSNMLP00000003161	annotation not available (429 aa)
	ENSNMLP00000002778	annotation not available (550 aa)
	ENSNMLP00000002236	Attractin. (1360 aa)
	ENSNMLP00000000903	Cell adhesion associated, oncogene regulated. (1103 aa)
	ENSNMLP00000024411	Low density lipoprotein receptor-related protein 4. (1908 aa)
	ENSNMLP00000024742	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a. (326 aa)
	ENSNMLP00000026367	Glycogen synthase kinase 3 beta, genome duplicate b. (437 aa)
	CUL3	Cullin 3. (766 aa)
	ENSNMLP00000027351	annotation not available (396 aa)
	ENSNMLP00000027867	annotation not available (424 aa)
	ENSNMLP00000028134	Hedgehog interacting protein. (699 aa)
	SMURF2	SMAD specific E3 ubiquitin protein ligase 2. (750 aa)
	ENSNMLP00000028746	annotation not available (900 aa)
	ENSNMLP00000029725	F-box and WD repeat domain containing 11a. (573 aa)
	ENSNMLP00000030280	Cullin 3b. (767 aa)
	ENSNMLP00000030378	G protein-coupled receptor 161. (519 aa)
	ENSNMLP00000030700	Casein kinase 1, delta b. (393 aa)
	ENSNMLP00000031059	Patched 2. (1298 aa)
	ENSNMLP00000031354	annotation not available (265 aa)
	ENSNMLP00000031526	annotation not available (1204 aa)
	ENSNMLP00000036413	GLI family zinc finger 3. (666 aa)
	ENSNMLP00000036414	annotation not available (73 aa)
	ENSNMLP00000036842	annotation not available (361 aa)
	ENSNMLP00000037216	BCL2 apoptosis regulator b. (210 aa)
	ENSNMLP00000037789	Cyclin D1. (294 aa)
	ENSNMLP00000038176	Smoothened, frizzled class receptor. (812 aa)
	ENSNMLP00000038522	Kinesin family member 7. (1334 aa)
	ENSNMLP00000038928	Growth arrest-specific 1a. (245 aa)
	ENSNMLP00000041529	Limb development membrane protein 1. (493 aa)
	ENSNMLP00000041553	Sonic hedgehog signaling molecule a. (407 aa)

Your Current Organism:

Neogobius melanostomus

NCBI taxonomy Id: 47308
Other names: Apollonia melanostoma, Apollonia melanostomus, Gobius melanostomus, N. melanostomus, round goby

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK1G2	ENSNMLP00000002778	ENSNMLP00000013110	ENSNMLP00000002778	Casein kinase 1 gamma 2.	annotation not available	0.678
CSNK1G2	ENSNMLP00000003816	ENSNMLP00000013110	ENSNMLP00000003816	Casein kinase 1 gamma 2.	annotation not available	0.838
CSNK1G2	ENSNMLP00000006239	ENSNMLP00000013110	ENSNMLP00000006239	Casein kinase 1 gamma 2.	Casein kinase 1, alpha 1.	0.792
CSNK1G2	ENSNMLP00000008650	ENSNMLP00000013110	ENSNMLP00000008650	Casein kinase 1 gamma 2.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b.	0.540
CSNK1G2	ENSNMLP00000012077	ENSNMLP00000013110	ENSNMLP00000012077	Casein kinase 1 gamma 2.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b.	0.540
CSNK1G2	ENSNMLP00000014619	ENSNMLP00000013110	ENSNMLP00000014619	Casein kinase 1 gamma 2.	GLI family zinc finger 2a.	0.472
CSNK1G2	ENSNMLP00000024742	ENSNMLP00000013110	ENSNMLP00000024742	Casein kinase 1 gamma 2.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a.	0.741
CSNK1G2	ENSNMLP00000026367	ENSNMLP00000013110	ENSNMLP00000026367	Casein kinase 1 gamma 2.	Glycogen synthase kinase 3 beta, genome duplicate b.	0.438
CSNK1G2	ENSNMLP00000027351	ENSNMLP00000013110	ENSNMLP00000027351	Casein kinase 1 gamma 2.	annotation not available	0.741
CSNK1G2	ENSNMLP00000030700	ENSNMLP00000013110	ENSNMLP00000030700	Casein kinase 1 gamma 2.	Casein kinase 1, delta b.	0.696
CSNK1G2	ENSNMLP00000036413	ENSNMLP00000013110	ENSNMLP00000036413	Casein kinase 1 gamma 2.	GLI family zinc finger 3.	0.472
CSNK1G2	ENSNMLP00000036414	ENSNMLP00000013110	ENSNMLP00000036414	Casein kinase 1 gamma 2.	annotation not available	0.472
CSNK1G2	ENSNMLP00000036842	ENSNMLP00000013110	ENSNMLP00000036842	Casein kinase 1 gamma 2.	annotation not available	0.678
CSNK1G2	ENSNMLP00000038176	ENSNMLP00000013110	ENSNMLP00000038176	Casein kinase 1 gamma 2.	Smoothened, frizzled class receptor.	0.678
CUL3	ENSNMLP00000006239	ENSNMLP00000027281	ENSNMLP00000006239	Cullin 3.	Casein kinase 1, alpha 1.	0.662
CUL3	ENSNMLP00000011856	ENSNMLP00000027281	ENSNMLP00000011856	Cullin 3.	Cyclin D2, a.	0.721
CUL3	ENSNMLP00000011944	ENSNMLP00000027281	ENSNMLP00000011944	Cullin 3.	Cyclin Dx.	0.670
CUL3	ENSNMLP00000012691	ENSNMLP00000027281	ENSNMLP00000012691	Cullin 3.	Suppressor of fused homolog (Drosophila).	0.855
CUL3	ENSNMLP00000014619	ENSNMLP00000027281	ENSNMLP00000014619	Cullin 3.	GLI family zinc finger 2a.	0.879
CUL3	ENSNMLP00000015878	ENSNMLP00000027281	ENSNMLP00000015878	Cullin 3.	Cullin 1a.	0.750