(26 nodes) Pyruvate metabolism network (Streptomyces cyaneogriseus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AJP00290.1	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
	AJP00291.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	AJP00292.1	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
	AJP01555.1	Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
	AJP01653.1	2-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa)
	AJP01706.1	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
	AJP01707.1	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
	AJP01709.1	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
	AJP01836.1	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
	AJP01920.1	Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (897 aa)
	AJP02039.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	AJP02040.1	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
	AJP02240.1	Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
	eno	Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
	ppc	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (913 aa)
	AJP02782.1	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
	AJP02783.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	AJP02784.1	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
	AJP02794.1	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
	AJP02795.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
	AJP02796.1	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
	pckG	Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (610 aa)
	kgd	Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1269 aa)
	AJP03877.1	Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
	AJP04367.1	Flavoprotein oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
	AJP04406.1	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)

Your Current Organism:

Streptomyces cyaneogriseus

NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJP00290.1	AJP00291.1	TU94_00730	TU94_00735	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJP00290.1	AJP00292.1	TU94_00730	TU94_00740	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
AJP00290.1	AJP01555.1	TU94_00730	TU94_08655	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
AJP00290.1	AJP01653.1	TU94_00730	TU94_09185	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.908
AJP00290.1	AJP01706.1	TU94_00730	TU94_09485	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.983
AJP00290.1	AJP01707.1	TU94_00730	TU94_09490	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.944
AJP00290.1	AJP01709.1	TU94_00730	TU94_09500	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.919
AJP00290.1	AJP01836.1	TU94_00730	TU94_10245	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.919
AJP00290.1	AJP01920.1	TU94_00730	TU94_10770	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family.	0.916
AJP00290.1	AJP02039.1	TU94_00730	TU94_11545	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJP00290.1	AJP02040.1	TU94_00730	TU94_11550	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.982
AJP00290.1	AJP02240.1	TU94_00730	TU94_12865	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
AJP00290.1	AJP02782.1	TU94_00730	TU94_16175	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.982
AJP00290.1	AJP02783.1	TU94_00730	TU94_16180	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJP00290.1	AJP02784.1	TU94_00730	TU94_16185	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AJP00290.1	AJP02794.1	TU94_00730	TU94_16245	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.982
AJP00290.1	AJP02795.1	TU94_00730	TU94_16250	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AJP00290.1	AJP02796.1	TU94_00730	TU94_16255	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
AJP00290.1	AJP03877.1	TU94_00730	TU94_22790	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
AJP00290.1	AJP04367.1	TU94_00730	TU94_25795	Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Flavoprotein oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.715