(9 nodes) Phosphotransferase activity, phosphate group as acceptor network (Streptomyces cyaneogriseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gmk	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (185 aa)
	cmk	Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
	ndk	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
	ppk	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (746 aa)
	adk	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
	thiL	Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
	AJP03998.1	Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
	pyrH	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (252 aa)
	AJP05370.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)

Your Current Organism:

Streptomyces cyaneogriseus

NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJP03998.1	thiL	TU94_23530	TU94_23525	Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.	0.962
AJP05370.1	gmk	TU94_32105	TU94_06075	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.701
AJP05370.1	pyrH	TU94_32105	TU94_23775	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.566
adk	gmk	TU94_19625	TU94_06075	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.826
adk	ndk	TU94_19625	TU94_11295	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.931
adk	pyrH	TU94_19625	TU94_23775	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.688
adk	thiL	TU94_19625	TU94_23525	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.	0.901
cmk	gmk	TU94_07405	TU94_06075	Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.665
cmk	ndk	TU94_07405	TU94_11295	Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.936
cmk	pyrH	TU94_07405	TU94_23775	Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.668
gmk	AJP05370.1	TU94_06075	TU94_32105	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.701
gmk	adk	TU94_06075	TU94_19625	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.826
gmk	cmk	TU94_06075	TU94_07405	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.665
gmk	ndk	TU94_06075	TU94_11295	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.938
gmk	pyrH	TU94_06075	TU94_23775	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.770
ndk	adk	TU94_11295	TU94_19625	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.931
ndk	cmk	TU94_11295	TU94_07405	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.936
ndk	gmk	TU94_11295	TU94_06075	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.938
ndk	pyrH	TU94_11295	TU94_23775	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.938
ppk	pyrH	TU94_17730	TU94_23775	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.771