(14 nodes) Ribosome assembly network (Streptomyces cyaneogriseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rpsS	30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
	rpsG	30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
	AJP03092.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
	AJP03007.1	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (747 aa)
	AJP02459.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
	rsfS	Ribosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (149 aa)
	era	GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (330 aa)
	der	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (492 aa)
	rplT	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (127 aa)
	AJP03669.1	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (849 aa)
	rimP	Ribosome maturation protein RimP; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (169 aa)
	AJP03626.1	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (638 aa)
	rpsK	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (134 aa)
	rplV	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (115 aa)

Your Current Organism:

Streptomyces cyaneogriseus

NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJP02459.1	AJP03626.1	TU94_14195	TU94_21220	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.610
AJP02459.1	rplT	TU94_14195	TU94_06675	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.425
AJP02459.1	rplV	TU94_14195	TU94_19545	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.594
AJP02459.1	rpsK	TU94_14195	TU94_19650	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.	0.738
AJP02459.1	rsfS	TU94_14195	TU94_11150	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ribosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.582
AJP03007.1	AJP03626.1	TU94_17515	TU94_21220	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
AJP03007.1	rplT	TU94_17515	TU94_06675	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.425
AJP03007.1	rplV	TU94_17515	TU94_19545	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.594
AJP03007.1	rpsK	TU94_17515	TU94_19650	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.	0.738
AJP03007.1	rsfS	TU94_17515	TU94_11150	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ribosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.582
AJP03092.1	AJP03626.1	TU94_18055	TU94_21220	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.607
AJP03092.1	rplT	TU94_18055	TU94_06675	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.425
AJP03092.1	rplV	TU94_18055	TU94_19545	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.	0.594
AJP03092.1	rpsK	TU94_18055	TU94_19650	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.	0.738
AJP03092.1	rsfS	TU94_18055	TU94_11150	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Ribosome-associated protein IOJAP; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.582
AJP03626.1	AJP02459.1	TU94_21220	TU94_14195	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.610
AJP03626.1	AJP03007.1	TU94_21220	TU94_17515	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	RNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.656
AJP03626.1	AJP03092.1	TU94_21220	TU94_18055	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.607
AJP03626.1	AJP03669.1	TU94_21220	TU94_21460	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	DEAD/DEAH box helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.603
AJP03626.1	der	TU94_21220	TU94_07395	GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology.	GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.	0.843