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ribBA ribBA ribH ribH AJP01071.1 AJP01071.1 bioA bioA bioB bioB AJP00932.1 AJP00932.1 AJP00913.1 AJP00913.1 AJP00893.1 AJP00893.1 AJP00820.1 AJP00820.1 AJP05490.1 AJP05490.1 AJP00428.1 AJP00428.1 AJP00338.1 AJP00338.1 AJP04972.1 AJP04972.1 AJP05002.1 AJP05002.1 cbiD cbiD AJP05055.1 AJP05055.1 AJP04098.1 AJP04098.1 cobH cobH panD panD AJP04198.1 AJP04198.1 AJP04213.1 AJP04213.1 cbiN cbiN cbiM cbiM dxs dxs AJP04388.1 AJP04388.1 AJP04459.1 AJP04459.1 dxs-2 dxs-2 AJP04676.1 AJP04676.1 AJP04700.1 AJP04700.1 dxs-3 dxs-3 kbl kbl AJP01414.1 AJP01414.1 AJP01412.1 AJP01412.1 cobB cobB AJP01411.1 AJP01411.1 cobN cobN cobQ cobQ cobD cobD AJP01415.1 AJP01415.1 AJP01416.1 AJP01416.1 thiE thiE AJP01642.1 AJP01642.1 AJP01643.1 AJP01643.1 thiG thiG AJP01701.1 AJP01701.1 cobT-2 cobT-2 cobS cobS panB panB AJP01819.1 AJP01819.1 AJP02115.1 AJP02115.1 AJP02403.1 AJP02403.1 AJP02503.1 AJP02503.1 pdxH pdxH serC serC panC panC AJP02579.1 AJP02579.1 AJP02581.1 AJP02581.1 AJP02582.1 AJP02582.1 AJP02600.1 AJP02600.1 AJP02676.1 AJP02676.1 AJP02872.1 AJP02872.1 thiC thiC AJP03009.1 AJP03009.1 AJP03843.1 AJP03843.1 thiL thiL AJP03998.1 AJP03998.1 AJP04053.1 AJP04053.1 AJP01401.1 AJP01401.1 AJP01167.1 AJP01167.1 cobT cobT pdxS pdxS pdxT pdxT AJP01077.1 AJP01077.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ribBA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (429 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (161 aa)
AJP01071.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (426 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (422 aa)
AJP00932.18-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
AJP00913.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AJP00893.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
AJP00820.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AJP05490.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (601 aa)
AJP00428.1Aldo/keto reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
AJP00338.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
AJP04972.1Precorrin 6A synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
AJP05002.13-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
cbiDcobalt-precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (372 aa)
AJP05055.1cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
AJP04098.1Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (318 aa)
cobHCatalyzes the interconversion of precorrin-8X and hydrogenobyrinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
panDAspartate 1-decarboxylase subunit alpha; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (139 aa)
AJP04198.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
AJP04213.1FAD-linked oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
cbiNHypothetical protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (123 aa)
cbiMCobalt transporter; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (226 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa)
AJP04388.1Diaminohydroxyphosphoribosylaminopyrimidine reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
AJP04459.1FAD-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
dxs-21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (599 aa)
AJP04676.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
AJP04700.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
dxs-31-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa)
kbl2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa)
AJP01414.1Precorrin-4 C11-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
AJP01412.1Precorrin-2 C20-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (247 aa)
cobBCobyrinic acid ac-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (451 aa)
AJP01411.1Cobinamide adenolsyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
cobNCobalamin biosynthesis protein CobN; With CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; Derived by automated computational analysis using gene prediction method: Protein Homology. (1215 aa)
cobQCobalamin biosynthesis protein CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (515 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (319 aa)
AJP01415.1precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
AJP01416.1Precorrin methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (563 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
AJP01642.1Glycine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
AJP01643.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)
AJP01701.1Adenosylcobinamide kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
cobT-2Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (371 aa)
cobSCMP-binding protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (280 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (288 aa)
AJP01819.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa)
AJP02115.1Tripeptidyl aminopeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AJP02403.1Cobalt ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
AJP02503.1Oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (222 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (323 aa)
AJP02579.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (286 aa)
AJP02581.1Diguanylate cyclase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
AJP02582.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AJP02600.1Cobalamin biosynthesis protein CobW; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
AJP02676.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa)
AJP02872.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (597 aa)
AJP03009.15-amino-6-(5-phosphoribosylamino)uracil reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
AJP03843.1Cob(I)yrinic acid a,c-diamide adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
AJP03998.1Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
AJP04053.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
AJP01401.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
AJP01167.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (1391 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (304 aa)
pdxTGlutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (202 aa)
AJP01077.1Riboflavin synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
Your Current Organism:
Streptomyces cyaneogriseus
NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus
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