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| | lipA | Radical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa) |
| | AJP01852.1 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa) |
| | AJP01885.1 | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa) |
| | AJP01993.1 | UDP-glucose:polyglycerol phosphate glucosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (677 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | AJP02034.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (111 aa) |
| | AJP02079.1 | Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa) |
| | AJP02082.1 | Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa) |
| | cysM | Cysteine synthase; Catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa) |
| | AJP02211.1 | Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (92 aa) |
| | AJP02212.1 | Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa) |
| | mtnA | Initiation factor 2B subunit alpha; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (380 aa) |
| | AJP02340.1 | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa) |
| | AJP02427.1 | Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (280 aa) |
| | acsA | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (358 aa) |
| | AJP02676.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (454 aa) |
| | AJP02784.1 | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa) |
| | AJP02796.1 | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa) |
| | AJP02876.1 | Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa) |
| | thiC | Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (597 aa) |
| | mshD | Mycothiol acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (309 aa) |
| | mshA | D-inositol 3-phosphate glycosyltransferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (445 aa) |
| | AJP03132.1 | Molybdenum cofactor biosynthesis protein MoaD; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa) |
| | mqnB | Futalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (235 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | AJP03543.1 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa) |
| | mshB | 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway. (291 aa) |
| | AJP03680.1 | Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] (392 aa) |
| | AJP03809.1 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (411 aa) |
| | AJP03879.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (702 aa) |
| | AJP03882.1 | Nucleosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa) |
| | AJP03936.1 | Methionine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa) |
| | AJP03998.1 | Phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa) |
| | AJP04053.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa) |
| | AJP04288.1 | 2-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa) |
| | AJP04334.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa) |
| | AJP04335.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa) |
| | AJP04426.1 | Sulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa) |
| | AJP05392.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa) |
| | egtA | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (437 aa) |
| | egtB | Sulfatase-modifying factor 1; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (439 aa) |
| | egtC | Hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (287 aa) |
| | egtD | histidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (320 aa) |
| | AJP05076.1 | Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa) |
| | AJP05006.1 | GlcNAc-PI de-N-acetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa) |
| | AJP05002.1 | 3-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa) |
| | kbl | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa) |
| | dxs-3 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa) |
| | AJP04676.1 | Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa) |
| | dxs-2 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (599 aa) |
| | AJP04608.1 | Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (608 aa) |
| | AJP04581.1 | Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (601 aa) |
| | AJP04489.1 | Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa) |
| | AJP04449.1 | Homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa) |
| | cysC | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (178 aa) |
| | AJP00290.1 | Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa) |
| | AJP00572.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa) |
| | AJP00573.1 | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa) |
| | AJP00753.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa) |
| | AJP00910.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa) |
| | AJP00911.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa) |
| | AJP00913.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa) |
| | AJP00932.1 | 8-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (422 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (426 aa) |
| | AJP00956.1 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa) |
| | AJP01035.1 | acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (658 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | AJP01256.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1171 aa) |
| | mshC | L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (409 aa) |
| | AJP01401.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa) |
| | AJP01637.1 | 5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (292 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa) |
| | AJP01642.1 | Glycine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa) |
| | AJP01643.1 | Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa) |
