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AJP04822.1 AJP04822.1 pgi-2 pgi-2 AJP05922.1 AJP05922.1 AJP04654.1 AJP04654.1 gap gap AJP04589.1 AJP04589.1 AJP04568.1 AJP04568.1 alc alc allB allB AJP04522.1 AJP04522.1 AJP04516.1 AJP04516.1 AJP04515.1 AJP04515.1 AJP04514.1 AJP04514.1 AJP05900.1 AJP05900.1 AJP04481.1 AJP04481.1 AJP04288.1 AJP04288.1 AJP04276.1 AJP04276.1 dut dut AJP04209.1 AJP04209.1 tdk tdk AJP04179.1 AJP04179.1 AJP05867.1 AJP05867.1 AJP04138.1 AJP04138.1 thyX thyX AJP04098.1 AJP04098.1 pyrH pyrH coaD coaD AJP03925.1 AJP03925.1 AJP03882.1 AJP03882.1 pfkA-2 pfkA-2 AJP03879.1 AJP03879.1 ackA ackA AJP03877.1 AJP03877.1 atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB AJP05815.1 AJP05815.1 AJP03688.1 AJP03688.1 AJP03530.1 AJP03530.1 AJP03519.1 AJP03519.1 AJP03516.1 AJP03516.1 AJP03513.1 AJP03513.1 AJP03500.1 AJP03500.1 AJP03499.1 AJP03499.1 AJP03475.1 AJP03475.1 AJP03469.1 AJP03469.1 AJP03444.1 AJP03444.1 folD folD purH purH purN purN sucC sucC guaA guaA AJP03396.1 AJP03396.1 guaB guaB nnrD nnrD coaA coaA glmM glmM adk adk AJP03283.1 AJP03283.1 mqnB mqnB AJP03130.1 AJP03130.1 gpmA gpmA AJP03046.1 AJP03046.1 purM purM purF purF purL purL purQ purQ purS purS purC purC purD purD upp upp AJP02873.1 AJP02873.1 AJP02796.1 AJP02796.1 AJP02794.1 AJP02794.1 AJP02784.1 AJP02784.1 AJP02782.1 AJP02782.1 dcd dcd AJP02717.1 AJP02717.1 pyrE pyrE AJP02697.1 AJP02697.1 kynU kynU purA purA AJP02641.1 AJP02641.1 acsA acsA AJP02586.1 AJP02586.1 AJP02568.1 AJP02568.1 coaX coaX AJP02530.1 AJP02530.1 purU purU AJP02498.1 AJP02498.1 AJP02427.1 AJP02427.1 AJP02424.1 AJP02424.1 prs prs glmU glmU AJP02359.1 AJP02359.1 eno eno purK purK purE purE AJP02321.1 AJP02321.1 AJP02320.1 AJP02320.1 AJP02318.1 AJP02318.1 AJP02314.1 AJP02314.1 AJP02294.1 AJP02294.1 AJP02237.1 AJP02237.1 AJP02217.1 AJP02217.1 AJP02216.1 AJP02216.1 AJP02202.1 AJP02202.1 AJP05655.1 AJP05655.1 AJP02144.1 AJP02144.1 AJP02125.1 AJP02125.1 nadE-2 nadE-2 AJP02040.1 AJP02040.1 AJP02034.1 AJP02034.1 ndk ndk nadD nadD AJP01956.1 AJP01956.1 AJP01954.1 AJP01954.1 AJP01947.1 AJP01947.1 AJP01900.1 AJP01900.1 AJP01885.1 AJP01885.1 AJP01836.1 AJP01836.1 nadE nadE AJP01709.1 AJP01709.1 AJP01707.1 AJP01707.1 nadA nadA AJP01659.1 AJP01659.1 AJP01606.1 AJP01606.1 AJP01556.1 AJP01556.1 AJP01555.1 AJP01555.1 coaE coaE AJP01519.1 AJP01519.1 psuG psuG AJP01493.1 AJP01493.1 pgk pgk tpiA tpiA pgi pgi ppnK ppnK pyrG pyrG AJP01342.1 AJP01342.1 cmk cmk AJP05547.1 AJP05547.1 apt apt AJP01129.1 AJP01129.1 pyrB pyrB pyrC pyrC AJP01104.1 AJP01104.1 carA carA carB carB pyrD pyrD pyrF pyrF gmk gmk AJP01097.1 AJP01097.1 AJP01088.1 AJP01088.1 AJP01067.1 AJP01067.1 AJP01035.1 AJP01035.1 AJP00998.1 AJP00998.1 AJP00946.1 AJP00946.1 AJP00911.1 AJP00911.1 AJP00910.1 AJP00910.1 pfkA pfkA AJP00885.1 AJP00885.1 AJP00855.1 AJP00855.1 AJP00799.1 AJP00799.1 AJP00798.1 AJP00798.1 AJP00743.1 AJP00743.1 AJP00573.1 AJP00573.1 AJP00248.1 AJP00248.1 AJP00280.1 AJP00280.1 AJP00290.1 AJP00290.1 AJP00292.1 AJP00292.1 AJP00307.1 AJP00307.1 AJP00384.1 AJP00384.1 AJP00385.1 AJP00385.1 AJP00434.1 AJP00434.1 AJP00482.1 AJP00482.1 add add AJP00501.1 AJP00501.1 AJP00523.1 AJP00523.1 AJP00649.1 AJP00649.1 AJP05392.1 AJP05392.1 AJP05370.1 AJP05370.1 AJP05298.1 AJP05298.1 AJP05990.1 AJP05990.1 AJP05285.1 AJP05285.1 AJP05262.1 AJP05262.1 AJP05257.1 AJP05257.1 AJP05247.1 AJP05247.1 AJP05035.1 AJP05035.1 AJP05034.1 AJP05034.1 AJP05013.1 AJP05013.1 AJP04999.1 AJP04999.1 AJP05936.1 AJP05936.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AJP04822.1ATP-grasp domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
pgi-2Glucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (550 aa)
AJP05922.11-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
AJP04654.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
AJP04589.1Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
AJP04568.1Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
alcAllantoicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the allantoicase family. (371 aa)
allBAllantoicase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (445 aa)
AJP04522.1Bleomycin resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
AJP04516.1Urate oxidase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (307 aa)
AJP04515.1Hydroxyisourate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (132 aa)
AJP04514.1OHCU decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
AJP05900.1D-beta-D-heptose 1-phosphate adenosyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (456 aa)
AJP04481.1XshC-Cox1-family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
AJP04288.12-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
AJP04276.1Nucleotide pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (189 aa)
AJP04209.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
AJP04179.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (219 aa)
AJP05867.1Kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (717 aa)
AJP04138.1Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (181 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
AJP04098.1Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (318 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (252 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
AJP03925.1TesB-like acyl-CoA thioesterase 3; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
AJP03882.1Nucleosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJP03879.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (702 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (411 aa)
AJP03877.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
atpCATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (124 aa)
atpDATP F0F1 synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (482 aa)
atpGATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (305 aa)
atpAATP synthase F0F1 subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (535 aa)
atpHATP synthase F0F1 subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (271 aa)
atpFATP synthase F0F1 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (186 aa)
atpEATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa)
atpBATP synthase F0F1 subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (264 aa)
AJP05815.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (330 aa)
AJP03688.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
AJP03530.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
AJP03519.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa)
AJP03516.1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (320 aa)
AJP03513.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
AJP03500.1Pyrimidine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
AJP03499.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJP03475.1OHCU decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
AJP03469.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
AJP03444.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (527 aa)
AJP03396.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (502 aa)
nnrDCarbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (482 aa)
coaAPantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (452 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
AJP03283.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
mqnBFutalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (235 aa)
AJP03130.1Glucosyl-3-phosphoglycerate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
AJP03046.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (601 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (752 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (234 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (90 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (299 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (417 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
AJP02873.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AJP02796.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AJP02794.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AJP02784.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
AJP02782.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
AJP02717.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (182 aa)
AJP02697.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (398 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
AJP02641.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AJP02586.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (186 aa)
AJP02568.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (327 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (265 aa)
AJP02530.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa)
AJP02498.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
AJP02427.1Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (280 aa)
AJP02424.1UTP--glucose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (482 aa)
AJP02359.1Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (386 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa)
AJP02321.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJP02320.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
AJP02318.1UDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
AJP02314.1acyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
AJP02294.1Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
AJP02237.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (190 aa)
AJP02217.1Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AJP02216.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (439 aa)
AJP02202.1Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
AJP05655.1Peptidase M6; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AJP02144.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
AJP02125.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
nadE-2NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (276 aa)
AJP02040.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
AJP02034.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (111 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (232 aa)
AJP01956.1Histidine triad (HIT) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
AJP01954.1Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (331 aa)
AJP01947.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
AJP01900.1Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
AJP01885.1acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
AJP01836.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (584 aa)
AJP01709.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AJP01707.1Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
AJP01659.1Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AJP01606.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
AJP01556.1Nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (600 aa)
AJP01555.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (209 aa)
AJP01519.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
psuGPseudouridine-5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (302 aa)
AJP01493.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (403 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (550 aa)
ppnKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (554 aa)
AJP01342.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
AJP05547.1HIT family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa)
AJP01129.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (845 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (332 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
AJP01104.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (380 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1102 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (368 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (282 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (185 aa)
AJP01097.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
AJP01088.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AJP01067.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
AJP01035.1acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (658 aa)
AJP00998.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
AJP00946.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
AJP00911.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AJP00910.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJP00885.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
AJP00855.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AJP00799.1Hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
AJP00798.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJP00743.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
AJP00573.1Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
AJP00248.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
AJP00280.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
AJP00290.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AJP00292.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
AJP00307.1VlmB-like protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
AJP00384.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
AJP00385.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AJP00434.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
AJP00482.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (359 aa)
AJP00501.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
AJP00523.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
AJP00649.1NAD-dependent dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AJP05392.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
AJP05370.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
AJP05298.1Fructose transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
AJP05990.1Flavin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
AJP05285.1dTDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (326 aa)
AJP05262.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
AJP05257.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJP05247.1Ribose-phosphate pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AJP05035.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
AJP05034.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
AJP05013.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
AJP04999.1Deoxyribose-phosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
AJP05936.1Hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
Your Current Organism:
Streptomyces cyaneogriseus
NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus
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