(12 nodes) Transketolase-like, pyrimidine-binding domain network (Streptomyces cyaneogriseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kgd	Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1269 aa)
	AJP00291.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	AJP01479.1	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (695 aa)
	AJP02039.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	AJP02783.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
	AJP02795.1	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
	dxs	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa)
	dxs-2	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (599 aa)
	AJP04657.1	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (615 aa)
	AJP04818.1	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (691 aa)
	dxs-3	1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa)
	AJP04950.1	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)

Your Current Organism:

Streptomyces cyaneogriseus

NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJP00291.1	AJP01479.1	TU94_00735	TU94_08225	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.651
AJP00291.1	AJP02039.1	TU94_00735	TU94_11545	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AJP00291.1	AJP02783.1	TU94_00735	TU94_16180	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
AJP00291.1	AJP02795.1	TU94_00735	TU94_16250	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.903
AJP00291.1	AJP04657.1	TU94_00735	TU94_27570	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.651
AJP00291.1	AJP04818.1	TU94_00735	TU94_28600	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.651
AJP00291.1	AJP04950.1	TU94_00735	TU94_29380	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.615
AJP00291.1	kgd	TU94_00735	TU94_22050	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
AJP01479.1	AJP00291.1	TU94_08225	TU94_00735	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.651
AJP01479.1	AJP02039.1	TU94_08225	TU94_11545	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.651
AJP01479.1	AJP02783.1	TU94_08225	TU94_16180	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.651
AJP01479.1	AJP02795.1	TU94_08225	TU94_16250	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.651
AJP01479.1	kgd	TU94_08225	TU94_22050	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.408
AJP02039.1	AJP00291.1	TU94_11545	TU94_00735	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AJP02039.1	AJP01479.1	TU94_11545	TU94_08225	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.651
AJP02039.1	AJP02783.1	TU94_11545	TU94_16180	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.901
AJP02039.1	AJP02795.1	TU94_11545	TU94_16250	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.903
AJP02039.1	AJP04657.1	TU94_11545	TU94_27570	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.651
AJP02039.1	AJP04818.1	TU94_11545	TU94_28600	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.651
AJP02039.1	AJP04950.1	TU94_11545	TU94_29380	2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.615