(34 nodes) AMP-binding enzyme network (Streptomyces cyaneogriseus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AJP01035.1	acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (658 aa)
	AJP05429.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
	AJP01002.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
	AJP05507.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (515 aa)
	AJP05503.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. (512 aa)
	AJP00658.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1307 aa)
	AJP00630.1	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (3069 aa)
	AJP00531.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
	AJP00529.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (605 aa)
	AJP00513.1	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
	AJP00512.1	phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (432 aa)
	AJP00443.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
	AJP06017.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2396 aa)
	AJP05984.1	Adenylate-forming protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (597 aa)
	AJP05165.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
	AJP05975.1	Amino acid adenylation domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. (515 aa)
	AJP05138.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family. (1440 aa)
	AJP05974.1	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (6673 aa)
	AJP05040.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (521 aa)
	AJP05951.1	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (2317 aa)
	AJP04969.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
	AJP04701.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (608 aa)
	AJP04496.1	AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (536 aa)
	AJP04288.1	2-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
	AJP03909.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
	AJP03238.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
	AJP02920.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (558 aa)
	acsA	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
	AJP02309.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
	AJP02087.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (641 aa)
	AJP01965.1	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (624 aa)
	AJP01884.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
	AJP01664.1	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (598 aa)
	AJP05556.1	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (554 aa)

Your Current Organism:

Streptomyces cyaneogriseus

NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJP00443.1	AJP00529.1	TU94_01785	TU94_02265	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.687
AJP00443.1	AJP01664.1	TU94_01785	TU94_09245	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.627
AJP00443.1	AJP01965.1	TU94_01785	TU94_11045	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.673
AJP00443.1	AJP02087.1	TU94_01785	TU94_11865	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.626
AJP00443.1	AJP03238.1	TU94_01785	TU94_18925	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.632
AJP00443.1	AJP04701.1	TU94_01785	TU94_27815	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.620
AJP00443.1	AJP04969.1	TU94_01785	TU94_29495	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.710
AJP00443.1	AJP05165.1	TU94_01785	TU94_30810	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.611
AJP00443.1	AJP05507.1	TU94_01785	TU94_04315	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.493
AJP00443.1	AJP05556.1	TU94_01785	TU94_07155	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.703
AJP00443.1	AJP06017.1	TU94_01785	TU94_32375	Long-chain fatty acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.420
AJP00512.1	AJP05138.1	TU94_02155	TU94_30645	phenylacetate--CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family.	0.603
AJP00513.1	AJP00630.1	TU94_02160	TU94_02965	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioester reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.408
AJP00513.1	AJP00658.1	TU94_02160	TU94_03195	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.477
AJP00513.1	AJP01002.1	TU94_02160	TU94_05490	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.866
AJP00513.1	AJP01035.1	TU94_02160	TU94_05715	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.476
AJP00513.1	AJP03909.1	TU94_02160	TU94_23015	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.405
AJP00513.1	AJP04288.1	TU94_02160	TU94_25315	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.511
AJP00513.1	AJP05138.1	TU94_02160	TU94_30645	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family.	0.798
AJP00513.1	AJP05503.1	TU94_02160	TU94_04270	acyl-CoA synthetase; Activates fatty acids by binding to coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ATP-dependent AMP-binding enzyme family.	0.428