STRINGSTRING
AJP00290.1 AJP00290.1 AJP00291.1 AJP00291.1 AJP00292.1 AJP00292.1 AJP00496.1 AJP00496.1 AJP00725.1 AJP00725.1 AJP01126.1 AJP01126.1 AJP01299.1 AJP01299.1 AJP01555.1 AJP01555.1 AJP01653.1 AJP01653.1 AJP01706.1 AJP01706.1 AJP01709.1 AJP01709.1 AJP01836.1 AJP01836.1 AJP01920.1 AJP01920.1 leuA leuA AJP02039.1 AJP02039.1 AJP02040.1 AJP02040.1 AJP02129.1 AJP02129.1 AJP02240.1 AJP02240.1 AJP02342.1 AJP02342.1 ppc ppc AJP02595.1 AJP02595.1 acsA acsA AJP02782.1 AJP02782.1 AJP02783.1 AJP02783.1 AJP02784.1 AJP02784.1 AJP02794.1 AJP02794.1 AJP02795.1 AJP02795.1 AJP02796.1 AJP02796.1 AJP05774.1 AJP05774.1 AJP03286.1 AJP03286.1 AJP03287.1 AJP03287.1 mdh mdh AJP05790.1 AJP05790.1 AJP03523.1 AJP03523.1 pckG pckG aspA aspA AJP03596.1 AJP03596.1 AJP03753.1 AJP03753.1 AJP03859.1 AJP03859.1 AJP03877.1 AJP03877.1 ackA ackA AJP03879.1 AJP03879.1 AJP05848.1 AJP05848.1 AJP04012.1 AJP04012.1 AJP04406.1 AJP04406.1 AJP04465.1 AJP04465.1 AJP04539.1 AJP04539.1 AJP04677.1 AJP04677.1 AJP04704.1 AJP04704.1 AJP04864.1 AJP04864.1 AJP05270.1 AJP05270.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJP00290.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AJP00291.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AJP00292.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
AJP00496.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (440 aa)
AJP00725.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
AJP01126.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AJP01299.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (462 aa)
AJP01555.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AJP01653.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa)
AJP01706.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AJP01709.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AJP01836.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
AJP01920.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (897 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
AJP02039.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
AJP02040.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
AJP02129.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (641 aa)
AJP02240.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
AJP02342.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (913 aa)
AJP02595.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (486 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AJP02782.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
AJP02783.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AJP02784.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
AJP02794.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AJP02795.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AJP02796.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AJP05774.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (428 aa)
AJP03286.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AJP03287.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AJP05790.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AJP03523.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (591 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (610 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (471 aa)
AJP03596.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (558 aa)
AJP03753.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
AJP03859.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
AJP03877.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (411 aa)
AJP03879.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (702 aa)
AJP05848.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
AJP04012.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
AJP04406.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AJP04465.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (580 aa)
AJP04539.1Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (541 aa)
AJP04677.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (597 aa)
AJP04704.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
AJP04864.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
AJP05270.1Lactate 2-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
Your Current Organism:
Streptomyces cyaneogriseus
NCBI taxonomy Id: 477245
Other names: S. cyaneogriseus subsp. noncyanogenus, Streptomyces cyaneogriseus subsp. noncyanogenus
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