STRINGSTRING
ku ku ruvC ruvC CCH90572.1 CCH90572.1 sbcD sbcD xerC xerC CCH86168.1 CCH86168.1 recR recR CCH85795.1 CCH85795.1 CCH86977.1 CCH86977.1 CCH87109.1 CCH87109.1 recO recO recA recA CCH89282.1 CCH89282.1 CCH89087.1 CCH89087.1 ruvB ruvB ligB ligB xerD xerD CCH88566.1 CCH88566.1 CCH87993.1 CCH87993.1 CCH87864.1 CCH87864.1 ruvA ruvA CCH86245.1 CCH86245.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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kuDNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (331 aa)
ruvCCrossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (196 aa)
CCH90572.1Phage integrase; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (373 aa)
sbcDExonuclease I SbcCD, subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (382 aa)
xerCTyrosine recombinase xerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (319 aa)
CCH86168.1Integrase; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (405 aa)
recRRecombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
CCH85795.1Prophage phiRv2 integrase; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (381 aa)
CCH86977.1Integrase family protein; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (299 aa)
CCH87109.1Integrase, Lambda phage type; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (377 aa)
recODNA repair protein recO; Involved in DNA repair and RecF pathway recombination. (248 aa)
recARecombinase A (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (346 aa)
CCH89282.1Integrase; Function of strongly homologous gene; enzyme. (334 aa)
CCH89087.1Putative Tyrosine recombinase xerC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the 'phage' integrase family. (307 aa)
ruvBHolliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (375 aa)
ligBATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (510 aa)
xerDTyrosine recombinase xerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (304 aa)
CCH88566.1Phage integrase; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (409 aa)
CCH87993.1Integrase; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (400 aa)
CCH87864.1Integrase/recombinase; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (342 aa)
ruvAHolliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (212 aa)
CCH86245.1Phage integrase; Function of strongly homologous gene; enzyme; Belongs to the 'phage' integrase family. (372 aa)
Your Current Organism:
Modestobacter marinus
NCBI taxonomy Id: 477641
Other names: CGMCC 4.5581, DSM 45201, M. marinus, Modestobacter marinus Xiao et al. 2011, Modestobacter sp. 42H12-1, strain 42H12-1
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