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thiL thiL thiE thiE Daud_2062 Daud_2062 Daud_2076 Daud_2076 metK metK Daud_2200 Daud_2200 Daud_0880 Daud_0880 Daud_0876 Daud_0876 Daud_0873 Daud_0873 Daud_0872 Daud_0872 Daud_0871 Daud_0871 thi4 thi4 Daud_0807 Daud_0807 Daud_0799 Daud_0799 mtnA mtnA thiM thiM Daud_0390 Daud_0390 Daud_0187 Daud_0187 Daud_0166 Daud_0166 Daud_0163 Daud_0163 Daud_0117 Daud_0117 Daud_0113 Daud_0113 Daud_0112 Daud_0112 Daud_0091 Daud_0091 folD folD Daud_0105 Daud_0105 Daud_0111 Daud_0111 Daud_2201 Daud_2201 Daud_1016 Daud_1016 asd asd Daud_0911 Daud_0911 Daud_0907 Daud_0907 Daud_0896 Daud_0896 folD-2 folD-2 dxs dxs accD accD accA accA Daud_1060 Daud_1060 Daud_1073 Daud_1073 sat sat Daud_1078 Daud_1078 Daud_1285 Daud_1285 Daud_1309 Daud_1309 Daud_1311 Daud_1311 bioF bioF bioD bioD bioA bioA bioB bioB Daud_1370 Daud_1370 Daud_1450 Daud_1450 acsA acsA Daud_1614 Daud_1614 Daud_1702 Daud_1702 metE metE thiC thiC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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gene co-occurrence
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thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (337 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (352 aa)
Daud_2062PFAM: LmbE family protein; KEGG: deh:cbdb_A213 LmbE-like family protein. (288 aa)
Daud_2076KEGG: chy:CHY_0042 hypothetical protein. (237 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa)
Daud_2200KEGG: mta:Moth_1600 sulfite reductase, dissimilatory-type beta subunit; TIGRFAM: sulfite reductase, dissimilatory-type beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region. (396 aa)
Daud_0880PFAM: methylenetetrahydrofolate reductase; KEGG: mta:Moth_1191 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (314 aa)
Daud_0876PFAM: dihydropteroate synthase, DHPS; KEGG: chy:CHY_1227 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase. (281 aa)
Daud_0873PFAM: ferredoxin; KEGG: chy:CHY_1224 iron-sulfur cluster binding protein. (630 aa)
Daud_0872PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit; Fe-S cluster domain protein; KEGG: chy:CHY_1223 acetyl-CoA decarbonylase/synthase complex subunit gamma. (443 aa)
Daud_0871KEGG: det:DET0700 carbon monoxide dehydrogenase, alpha subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit. (735 aa)
thi4Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (259 aa)
Daud_0807KEGG: bpm:BURPS1710b_A2410 hypothetical protein. (157 aa)
Daud_0799Phosphoadenosine phosphosulfate reductase; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; phosphoadenosine phosphosulfate reductase; KEGG: pai:PAE1989 hypothetical protein. (755 aa)
mtnAPutative translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (348 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (273 aa)
Daud_0390PFAM: LmbE family protein; KEGG: dge:Dgeo_2557 hypothetical protein. (249 aa)
Daud_0187TIGRFAM: serine O-acetyltransferase; KEGG: chy:CHY_2339 serine acetyltransferase. (238 aa)
Daud_0166PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: sth:STH353 putative biotin synthetase. (370 aa)
Daud_0163PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; SMART: Elongator protein 3/MiaB/NifB; KEGG: swo:Swol_1022 thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (491 aa)
Daud_0117PFAM: methylenetetrahydrofolate reductase; KEGG: mta:Moth_1191 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (306 aa)
Daud_0113PFAM: dihydropteroate synthase, DHPS; KEGG: chy:CHY_1227 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase. (290 aa)
Daud_0112PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit; Fe-S cluster domain protein; KEGG: det:DET0699 corrinoid/iron-sulfur protein, large subunit. (452 aa)
Daud_0091Conserved hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (304 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
Daud_0105KEGG: mth:MTH1708 carbon monoxide dehydrogenase, alpha subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Prismane. (766 aa)
Daud_0111KEGG: mja:MJ0156 acetyl-CoA decarbonylase/synthase, subunit beta; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit. (399 aa)
Daud_2201KEGG: mta:Moth_1601 sulfite reductase, dissimilatory-type alpha subunit; TIGRFAM: sulfite reductase, dissimilatory-type alpha subunit; PFAM: nitrite and sulphite reductase 4Fe-4S region. (473 aa)
Daud_1016acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
Daud_0911PFAM: protein of unknown function DUF39; KEGG: swo:Swol_1441 conserved hypothetical cytosolic protein. (405 aa)
Daud_0907PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: chy:CHY_2199 cysteine desulfurase. (383 aa)
Daud_0896PFAM: DRTGG domain protein; KEGG: dvu:DVU1438 cobyrinic acid a,c-diamide synthase family protein. (351 aa)
folD-2Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (634 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (275 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (315 aa)
Daud_1060PFAM: nitrogen-fixing NifU domain protein; KEGG: bcl:ABC2939 nitrogen fixation protein. (43 aa)
Daud_1073PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding; KEGG: mta:Moth_1307 homoserine dehydrogenase. (431 aa)
satKEGG: cte:CT0862 sulfate adenylyltransferase; TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family. (420 aa)
Daud_1078KEGG: mpa:MAP2598c sulfate adenylyltransferase; TIGRFAM: sulfate adenylyltransferase; PFAM: ATP-sulfurylase. (420 aa)
Daud_1285KEGG: swo:Swol_0596 hypothetical protein. (367 aa)
Daud_1309PFAM: (2R)-phospho-3-sulfolactate synthase, ComA; KEGG: mta:Moth_0118 (2R)-phospho-3-sulfolactate synthase, ComA. (262 aa)
Daud_1311TIGRFAM: cysteine synthases; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: pca:Pcar_3005 cysteine synthase B. (302 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (384 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (263 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (453 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (328 aa)
Daud_1370PFAM: SufBD protein; KEGG: deh:cbdb_A794 iron-regulated ABC transporter, subunit SufB-related. (394 aa)
Daud_1450KEGG: mta:Moth_0833 hypothetical protein. (361 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
Daud_1614PFAM: Thiamin pyrophosphokinase, catalytic region; KEGG: tte:TTE1305 hypothetical protein. (375 aa)
Daud_1702PFAM: phosphoadenosine phosphosulfate reductase; KEGG: dvu:DVU1566 phosphoadenosine phosphosulfate reductase, putative. (228 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (432 aa)
Your Current Organism:
Desulforudis audaxviator
NCBI taxonomy Id: 477974
Other names: C. Desulforudis audaxviator MP104C, Candidatus Desulforudis audaxviator MP104C, Candidatus Desulforudis audaxviator str. MP104C, Candidatus Desulforudis audaxviator strain MP104C
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