STRINGSTRING
KIR64206.1 KIR64206.1 Gnd Gnd KIR64433.1 KIR64433.1 KIR64493.1 KIR64493.1 PdhA PdhA FbaA FbaA KIR64540.1 KIR64540.1 KIR64562.1 KIR64562.1 KIR64563.1 KIR64563.1 KIR64633.1 KIR64633.1 KIR64657.1 KIR64657.1 acsA acsA KIR64778.1 KIR64778.1 KIR64813.1 KIR64813.1 KIR64814.1 KIR64814.1 KIR64826.1 KIR64826.1 KIR64964.1 KIR64964.1 KIR64965.1 KIR64965.1 prs prs KIR65086.1 KIR65086.1 KIR65102.1 KIR65102.1 KIR65116.1 KIR65116.1 GlpX GlpX ppc ppc eno eno KIR65166.1 KIR65166.1 KIR65186.1 KIR65186.1 KIR65284.1 KIR65284.1 KIR65312.1 KIR65312.1 KIR66817.1 KIR66817.1 KIR65473.1 KIR65473.1 KIR65677.1 KIR65677.1 KIR65843.1 KIR65843.1 KIR65983.1 KIR65983.1 sdhA sdhA KIR66910.1 KIR66910.1 KIR66027.1 KIR66027.1 KIR66223.1 KIR66223.1 KIR66263.1 KIR66263.1 KIR66362.1 KIR66362.1 pgi pgi KIR66493.1 KIR66493.1 KIR66544.1 KIR66544.1 KIR62758.1 KIR62758.1 aspA aspA gpmA gpmA KIR63077.1 KIR63077.1 sucC sucC sucD sucD folD folD Mdh Mdh KIR63089.1 KIR63089.1 KIR63105.1 KIR63105.1 KIR63116.1 KIR63116.1 sdhA-2 sdhA-2 KIR63194.1 KIR63194.1 ackA ackA Pta Pta kgd kgd KIR63271.1 KIR63271.1 KIR63274.1 KIR63274.1 Mce Mce KIR63289.1 KIR63289.1 KIR63292.1 KIR63292.1 KIR63399.1 KIR63399.1 GndA GndA PpdK PpdK KIR62048.1 KIR62048.1 AceE AceE LpdA LpdA GcvT GcvT KIR60823.1 KIR60823.1 pfp pfp MetF MetF Pyk Pyk Gap Gap pgk pgk tpiA tpiA pgl pgl zwf zwf tal tal KIR60991.1 KIR60991.1 acnA acnA KIR61064.1 KIR61064.1 KIR61101.1 KIR61101.1 Rpe Rpe KIR61409.1 KIR61409.1 AceA AceA KIR61450.1 KIR61450.1 KIR61590.1 KIR61590.1 glyA-3 glyA-3 PdhA-2 PdhA-2 KIR61763.1 KIR61763.1 KIR61914.1 KIR61914.1 KIR61915.1 KIR61915.1 KIR61916.1 KIR61916.1 gcvH gcvH gcvP gcvP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KIR64206.1Gluconolactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
Gnd6-phosphogluconate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
KIR64433.1Biotin carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
KIR64493.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
PdhAPyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
FbaAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
KIR64540.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
KIR64562.13-hydroxybutyryl-CoA dehydrogenase; Converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
KIR64563.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
KIR64633.1Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
KIR64657.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa)
KIR64778.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
KIR64813.1Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (375 aa)
KIR64814.1Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (368 aa)
KIR64826.1Serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (456 aa)
KIR64964.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
KIR64965.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (614 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
KIR65086.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
KIR65102.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
KIR65116.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
GlpXFructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (928 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
KIR65166.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
KIR65186.1Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
KIR65284.1Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
KIR65312.1Methylaspartate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
KIR66817.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (785 aa)
KIR65473.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (532 aa)
KIR65677.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (491 aa)
KIR65843.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
KIR65983.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (645 aa)
KIR66910.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
KIR66027.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
KIR66223.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
KIR66263.1Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (753 aa)
KIR66362.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (545 aa)
KIR66493.12-dehydro-3-deoxyphosphogluconate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
KIR66544.1Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
KIR62758.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (255 aa)
KIR63077.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
MdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (316 aa)
KIR63089.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
KIR63105.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
KIR63116.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
sdhA-2Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (638 aa)
KIR63194.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (375 aa)
PtaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (689 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1258 aa)
KIR63271.13-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
KIR63274.1Protein meaA; Derived by automated computational analysis using gene prediction method: Protein Homology. (667 aa)
MceGlyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
KIR63289.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
KIR63292.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
KIR63399.1Catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
GndA6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (481 aa)
PpdKPyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (902 aa)
KIR62048.1ROK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
AceEPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (914 aa)
LpdADihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
GcvTGlycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
KIR60823.1Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
MetF5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (305 aa)
PykPyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
GapGlyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (399 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (256 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (504 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (392 aa)
KIR60991.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transketolase family. (712 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (951 aa)
KIR61064.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
KIR61101.1Carbohydrate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
RpeRibulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa)
KIR61409.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (309 aa)
AceAIsocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
KIR61450.1Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (536 aa)
KIR61590.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (427 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (479 aa)
PdhA-2Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
KIR61763.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
KIR61914.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
KIR61915.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (878 aa)
KIR61916.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (940 aa)
Your Current Organism:
Micromonospora carbonacea
NCBI taxonomy Id: 47853
Other names: ATCC 27114, ATCC 27115, DSM 43168, DSM 43815, IFO 14107, IFO 14108, JCM 3139, M. carbonacea, Micromonospora carbonacea subsp. aurantiaca, Micromonospora carbonacea subsp. carbonacea, NBRC 14108, NRRL 2972
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