STRINGSTRING
arnE arnE wecD wecD ALX92365.1 ALX92365.1 wecC wecC wecB wecB wzzE wzzE wecA wecA ALX92379.1 ALX92379.1 ALX92380.1 ALX92380.1 bcsA bcsA ALX92383.1 ALX92383.1 ALX92384.1 ALX92384.1 ALX92385.1 ALX92385.1 ALX92386.1 ALX92386.1 eptB eptB wecH wecH ALX92681.1 ALX92681.1 waaA waaA ALX92683.1 ALX92683.1 ALX92684.1 ALX92684.1 ALX92685.1 ALX92685.1 ALX92686.1 ALX92686.1 ALX92688.1 ALX92688.1 ALX92690.1 ALX92690.1 ALX92691.1 ALX92691.1 ALX92692.1 ALX92692.1 rfaF_1 rfaF_1 ALX92821.1 ALX92821.1 glgB glgB glgC glgC glgA glgA ALX93083.1 ALX93083.1 ALX94200.1 ALX94200.1 ALX94246.1 ALX94246.1 ALX94248.1 ALX94248.1 ALX94249.1 ALX94249.1 ALX94354.1 ALX94354.1 ALX94357.1 ALX94357.1 ALX94361.1 ALX94361.1 ALX94363.1 ALX94363.1 ALX94369.1 ALX94369.1 ALX94370.1 ALX94370.1 ALX94374.1 ALX94374.1 kdsB kdsB ALX94531.1 ALX94531.1 ALX94532.1 ALX94532.1 opgC opgC mdoG mdoG mdoH mdoH lpxL lpxL arnB arnB arnC arnC arnA arnA arnD arnD arnT arnT arnF arnF ALX94967.1 ALX94967.1 ALX95130.1 ALX95130.1 rffG_3 rffG_3 lpxM lpxM ALX95455.1 ALX95455.1 kdsA kdsA spr_2 spr_2 ALX95585.1 ALX95585.1 yeiU yeiU spr spr gutQ gutQ ALX96276.1 ALX96276.1 ALX96289.1 ALX96289.1 ALX96469.1 ALX96469.1 ALX96876.1 ALX96876.1 ALX96970.1 ALX96970.1 ALX96971.1 ALX96971.1 ALX97048.1 ALX97048.1 wecE wecE wzxE wzxE wecF wecF wzyE wzyE wecG wecG lpxP lpxP kdsC kdsC ALX92092.1 ALX92092.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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arnE4-amino-4-deoxy-L-arabinose-phospho-UDP flippase; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (114 aa)
wecDTDP-fucosamine acetyltransferase; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (239 aa)
ALX92365.1Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
wecCUDP-N-acetyl-D-mannosamine dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
wecBUDP-N-acetyl glucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (376 aa)
wzzELipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (350 aa)
wecAUDP-phosphate N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (365 aa)
ALX92379.1Cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; Derived by automated computational analysis using gene prediction method: Protein Homology. (1157 aa)
ALX92380.1Cellulose synthase; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); Belongs to the AcsB/BcsB family. (769 aa)
bcsACellulose synthase catalytic subunit; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (867 aa)
ALX92383.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (64 aa)
ALX92384.1Cellulose biosynthesis protein BcsE; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
ALX92385.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
ALX92386.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
eptBCatalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)
wecHAcetyltransferase; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. (330 aa)
ALX92681.1Lipopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
waaA3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
ALX92683.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
ALX92684.1Glycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
ALX92685.1Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
ALX92686.1Glycosyl transferase family 9; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
ALX92688.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
ALX92690.1Ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
ALX92691.1Lipopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
ALX92692.1ADP-heptose--LPS heptosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
rfaF_1ADP-heptose--LPS heptosyltransferase; Catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
ALX92821.1ADP-heptose--LPS heptosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
glgBGlycogen-branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (727 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (425 aa)
glgAGlycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (477 aa)
ALX93083.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
ALX94200.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
ALX94246.1Hypothetical protein; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose. (703 aa)
ALX94248.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1329 aa)
ALX94249.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (161 aa)
ALX94354.1UDP-phosphate N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the formation of alpha-N-acetylglucosaminyl-pyrophosphoryl-undecaprenyl from alpha-N-acetylglucosaminyl 1-phosphate and the lipid carrier undecaprenyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
ALX94357.1Tyrosine protein kinase; Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
ALX94361.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (361 aa)
ALX94363.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (359 aa)
ALX94369.1NAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
ALX94370.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
ALX94374.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa)
ALX94531.1O-antigen biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
ALX94532.1Lipopolysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
opgCGlucans biosynthesis protein; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (375 aa)
mdoGGlucan biosynthesis protein G; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (497 aa)
mdoHGlucosyltransferase MdoH; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (853 aa)
lpxLLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
arnBUDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (384 aa)
arnCUndecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (326 aa)
arnAUDP-4-amino-4-deoxy-L-arabinose formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (660 aa)
arnD4-deoxy-4-formamido-L-arabinose-phospho-UDP deformylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (303 aa)
arnT4-amino-4-deoxy-L-arabinose lipid A transferase; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (554 aa)
arnF4-amino-4-deoxy-L-arabinose-phospho-UDP flippase; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (129 aa)
ALX94967.1Phosphoethanolamine transferase EptA; Derived by automated computational analysis using gene prediction method: Protein Homology. (543 aa)
ALX95130.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (322 aa)
rffG_3Protein CapI; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa)
ALX95455.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
kdsATransporter; Role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family. (284 aa)
spr_2Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
ALX95585.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (248 aa)
yeiUHypothetical protein; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (236 aa)
sprLipoprotein Spr; Mutational suppressor of prc thermosensitivity; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
gutQArabinose-5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
ALX96276.1Phosphoethanolamine transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
ALX96289.1Bactoprenol glucosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
ALX96469.1D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
ALX96876.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
ALX96970.1D-arabinose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
ALX96971.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
ALX97048.1Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
wecEdTDP-4-amino-4,6-dideoxygalactose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
wzxEO-antigen translocase; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. (416 aa)
wecF4-alpha-L-fucosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. (361 aa)
wzyEEnterobacterial common antigen polymerase; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family. (455 aa)
wecGUDP-N-acetyl-D-mannosaminuronic acid transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (246 aa)
lpxPLipid A biosynthesis palmitoleoyl acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (184 aa)
ALX92092.1D-arabinose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
Your Current Organism:
Serratia fonticola
NCBI taxonomy Id: 47917
Other names: ATCC 29844, CCUG 14186, CCUG 37824, CCUG 57457 [[Serratia glossinae]], CIP 78.64, DSM 22080 [[Serratia glossinae]], DSM 4576, LMG 7882, LMG:7882, NBRC 102597, NCTC 12965, S. fonticola, Serratia glossinae, Serratia glossinae Geiger et al. 2010, strain 11, strain C1 [[Serratia glossinae]]
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