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| | Sros_0061 | Homoserine O-acetyltransferase; KEGG: bra:BRADO5867 hypothetical protein; Belongs to the AB hydrolase superfamily. MetX family. (338 aa) |
| | Sros_0110 | KEGG: gbe:GbCGDNIH1_0821 anthranilate synthase component II. (190 aa) |
| | pheA | KEGG: ade:Adeh_1779 prephenate dehydratase. (306 aa) |
| | Sros_0327 | Succinyl-diaminopimelate desuccinylase; KEGG: dde:Dde_1186 M20/M25/M40 family peptidase. (434 aa) |
| | pat | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (353 aa) |
| | Sros_0500 | Phosphoserine phosphatase; KEGG: scl:sce0663 hypothetical protein. (407 aa) |
| | Sros_0542 | Phosphoserine phosphatase-like protein; KEGG: afw:Anae109_1214 HAD family hydrolase. (289 aa) |
| | Sros_0868 | KEGG: afw:Anae109_3449 inositol-phosphate phosphatase. (267 aa) |
| | serC | Phosphoserine aminotransferase-like protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (369 aa) |
| | Sros_1066 | KEGG: ppd:Ppro_2189 aminotransferase, class I and II. (401 aa) |
| | Sros_1268 | Aminoacylase; KEGG: bsu:BSU29290 hypothetical protein. (412 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (475 aa) |
| | ahcY-2 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (413 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (460 aa) |
| | Sros_1638 | KEGG: gme:Gmet_1629 homoserine dehydrogenase. (430 aa) |
| | Sros_1649 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (336 aa) |
| | Sros_1754 | KEGG: mms:mma_3335 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | Sros_1950 | KEGG: wsu:WS0167 hypothetical protein. (408 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa) |
| | Sros_2137 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1245 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (268 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (569 aa) |
| | Sros_2555 | KEGG: dvm:DvMF_0572 threonine aldolase. (352 aa) |
| | Sros_2587 | Cystathionine gamma-synthase; KEGG: cko:CKO_04984 hypothetical protein. (390 aa) |
| | Sros_2589 | KEGG: mlo:mlr3510 threonine dehydratase. (303 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | Sros_2740 | KEGG: bsu:BSU02410 homocysteine methyltransferase. (287 aa) |
| | Sros_2759 | 3-deoxy-7-phosphoheptulonate synthase; KEGG: afw:Anae109_0367 phospho-2-dehydro-3- deoxyheptonate aldolase. (345 aa) |
| | Sros_2788 | KEGG: afw:Anae109_2667 5,10- methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (310 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa) |
| | Sros_2890 | 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase-like protein; KEGG: mxa:MXAN_3526 phospho-2-dehydro-3- deoxyheptonate aldolase. (264 aa) |
| | Sros_2906 | KEGG: dvm:DvMF_2065 YbaK/EbsC protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (166 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisC | KEGG: bur:Bcep18194_C7445 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | hisB | KEGG: dal:Dalk_3080 imidazoleglycerol-phosphate dehydratase. (206 aa) |
| | Sros_2910 | Hypothetical protein. (51 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa) |
| | Sros_2912 | Hypothetical protein. (113 aa) |
| | hisA | Phosphoribosylanthranilate isomerase; KEGG: plu:plu0797 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase. (240 aa) |
| | Sros_2914 | KEGG: mxa:MXAN_5993 hypothetical protein. (135 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (115 aa) |
| | trpC | KEGG: afw:Anae109_0373 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpB | Tryptophan synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (264 aa) |
| | Sros_2997 | KEGG: ade:Adeh_0182 chorismate mutase. (119 aa) |
| | Sros_2998 | Prephenate dehydrogenase-like protein; KEGG: bpt:Bpet1887 hypothetical protein. (357 aa) |
| | Sros_3052 | KEGG: vei:Veis_4212 thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family. (584 aa) |
| | Sros_3143 | Aminotransferase; KEGG: bsu:BSU31440 aminotransferase. (381 aa) |
| | Sros_3288 | KEGG: rce:RC1_0952 3-deoxy-7-phosphoheptulonate synthase; Belongs to the class-II DAHP synthase family. (443 aa) |
| | trpF | KEGG: sil:SPO0806 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (211 aa) |
| | Sros_3752 | KEGG: bbt:BBta_0633 putative cysteine synthase (O- acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSase). (351 aa) |
| | Sros_3761 | KEGG: oca:OCAR_5217 para-aminobenzoate synthase. (703 aa) |
| | Sros_3775 | 3-deoxy-7-phosphoheptulonate synthase; KEGG: ppf:Pput_3849 phospho-2-dehydro-3- deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (388 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (579 aa) |
| | aroK | 3-dehydroquinate synthase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | Sros_3982 | KEGG: scl:sce5044 anthranilate synthase. (715 aa) |
| | Sros_4119 | KEGG: aca:ACP_1470 threonine dehydratase catabolic. (319 aa) |
| | Sros_4372 | KEGG: mrd:Mrad2831_1541 pyridoxal-5'-phosphate- dependent protein beta subunit. (392 aa) |
| | trpB-2 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA-2 | Tryptophan synthase; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa) |
| | Sros_5214 | KEGG: afw:Anae109_2478 inositol monophosphatase. (267 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (153 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (451 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (302 aa) |
| | Sros_5917 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1154 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphohydrolase-like protein; KEGG: smt:Smal_1763 phosphoribosyl-ATP diphosphatase. (87 aa) |
| | Sros_6090 | KEGG: bam:Bamb_5913 shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (274 aa) |
| | dapD | Putative tetrahydrodipicolinate N- succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (325 aa) |
| | Sros_6148 | KEGG: sde:Sde_3057 branched chain amino acid aminotransferase. (276 aa) |
| | Sros_6149 | Anthranilate synthase; KEGG: met:M446_0053 para-aminobenzoate synthase, subunit I. (340 aa) |
| | dapA-2 | Dihydrodipicolinate synthase family protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (288 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (358 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (392 aa) |
| | Sros_6569 | KEGG: mxa:MXAN_3751 aminotransferase, classes I and II. (394 aa) |
| | glyA-2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | Sros_6775 | KEGG: csa:Csal_1824 inositol-1(or 4)- monophosphatase. (264 aa) |
| | Sros_6984 | KEGG: bpt:Bpet1887 hypothetical protein. (283 aa) |
| | Sros_6985 | 3-deoxy-7-phosphoheptulonate synthase; KEGG: glo:Glov_2802 phospho-2-dehydro-3- deoxyheptonate aldolase. (346 aa) |
| | trpD-2 | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate--homocyste ineS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (738 aa) |
| | ilvD | KEGG: nmn:NMCC_1068 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa) |
| | Sros_7680 | Hippurate hydrolase; KEGG: sal:Sala_2314 peptidase M20D, amidohydrolase. (399 aa) |
| | Sros_8009 | KEGG: sfu:Sfum_2670 cystathionine gamma-synthase. (406 aa) |
| | leuD | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (459 aa) |
| | Sros_8038 | KEGG: scl:sce3734 putative alpha- isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (525 aa) |
| | Sros_8041 | KEGG: nar:Saro_2671 branched-chain amino acid aminotransferase. (364 aa) |
| | Sros_8042 | KEGG: sfu:Sfum_3031 isocitrate/isopropylmalate dehydrogenase. (348 aa) |
| | Sros_8047 | KEGG: dal:Dalk_3379 D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | Sros_8058 | KEGG: gur:Gura_3719 acetolactate synthase 3 regulatory subunit. (174 aa) |
| | Sros_8059 | KEGG: ade:Adeh_1978 acetolactate synthase, large subunit. (578 aa) |
| | Sros_8078 | KEGG: mxa:MXAN_1973 hypothetical protein. (334 aa) |
| | Sros_8241 | KEGG: acr:Acry_2572 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (346 aa) |
| | Sros_8313 | KEGG: scl:sce8127 putative acetolactate synthase; Belongs to the TPP enzyme family. (550 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (425 aa) |
| | Sros_8330 | KEGG: ade:Adeh_1287 histidinol-phosphate phosphatase. (267 aa) |
| | Sros_8429 | Dipeptidase; KEGG: scl:sce2952 dipeptidase. (353 aa) |
| | Sros_8431 | KEGG: bba:Bd1775 2,3,4,5-tetrahydropyridine-2- carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (276 aa) |
| | Sros_8547 | KEGG: gme:Gmet_3072 threonine dehydratase. (402 aa) |
| | Sros_8563 | KEGG: afw:Anae109_3845 cystathionine gamma-lyase. (379 aa) |
| | Sros_8566 | KEGG: scl:sce0438 cystathionine beta-synthase. (456 aa) |
| | Sros_8776 | MetE; KEGG: dat:HRM2_34760 MetE. (367 aa) |
| | Sros_8789 | KEGG: sfu:Sfum_0366 adenosylhomocysteinase. (386 aa) |
| | Sros_8913 | KEGG: aca:ACP_3389 threonine synthase. (429 aa) |
| | Sros_8985 | 5 10-methylenetetrahydrofolate reductase-like protein; KEGG: gur:Gura_1171 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (259 aa) |
| | Sros_9103 | KEGG: msl:Msil_2816 thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family. (577 aa) |
| | Sros_9291 | Aminotransferase; KEGG: csa:Csal_1034 aminotransferase. (426 aa) |
| | Sros_9310 | KEGG: pca:Pcar_1903 aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa) |
| | Sros_9311 | Aspartate kinase; KEGG: dat:HRM2_35870 LysC; Belongs to the aspartokinase family. (424 aa) |
| | Sros_9365 | KEGG: sme:SM_b20249 putative myo-inositol-1- phosphate synthase. (359 aa) |
| | Sros_9381 | KEGG: dvm:DvMF_0572 threonine aldolase. (352 aa) |
