STRINGSTRING
Sros_0061 Sros_0061 Sros_0327 Sros_0327 Sros_0500 Sros_0500 serC serC Sros_1268 Sros_1268 ahcY ahcY ahcY-2 ahcY-2 lysA lysA Sros_1638 Sros_1638 Sros_1649 Sros_1649 thrB thrB Sros_1754 Sros_1754 Sros_1950 Sros_1950 dapB dapB Sros_2137 Sros_2137 dapA dapA dapF dapF leuA leuA Sros_2555 Sros_2555 Sros_2587 Sros_2587 Sros_2589 Sros_2589 Sros_2740 Sros_2740 Sros_2788 Sros_2788 metK metK Sros_3052 Sros_3052 Sros_3143 Sros_3143 Sros_3752 Sros_3752 leuA-2 leuA-2 Sros_4119 Sros_4119 Sros_4372 Sros_4372 lysA-2 lysA-2 ilvE ilvE Sros_5917 Sros_5917 dapD dapD Sros_6148 Sros_6148 dapA-2 dapA-2 Sros_6569 Sros_6569 glyA-2 glyA-2 metE metE ilvD ilvD Sros_7680 Sros_7680 Sros_8009 Sros_8009 leuD leuD leuC leuC Sros_8038 Sros_8038 Sros_8041 Sros_8041 Sros_8042 Sros_8042 Sros_8047 Sros_8047 ilvC ilvC Sros_8058 Sros_8058 Sros_8059 Sros_8059 Sros_8078 Sros_8078 Sros_8241 Sros_8241 Sros_8313 Sros_8313 Sros_8429 Sros_8429 Sros_8431 Sros_8431 Sros_8547 Sros_8547 Sros_8563 Sros_8563 Sros_8566 Sros_8566 Sros_8776 Sros_8776 Sros_8789 Sros_8789 Sros_8913 Sros_8913 Sros_8985 Sros_8985 Sros_9103 Sros_9103 Sros_9310 Sros_9310 Sros_9311 Sros_9311 Sros_9381 Sros_9381
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Sros_0061Homoserine O-acetyltransferase; KEGG: bra:BRADO5867 hypothetical protein; Belongs to the AB hydrolase superfamily. MetX family. (338 aa)
Sros_0327Succinyl-diaminopimelate desuccinylase; KEGG: dde:Dde_1186 M20/M25/M40 family peptidase. (434 aa)
Sros_0500Phosphoserine phosphatase; KEGG: scl:sce0663 hypothetical protein. (407 aa)
serCPhosphoserine aminotransferase-like protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (369 aa)
Sros_1268Aminoacylase; KEGG: bsu:BSU29290 hypothetical protein. (412 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (475 aa)
ahcY-2Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (413 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (460 aa)
Sros_1638KEGG: gme:Gmet_1629 homoserine dehydrogenase. (430 aa)
Sros_1649L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (336 aa)
Sros_1754KEGG: mms:mma_3335 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
Sros_1950KEGG: wsu:WS0167 hypothetical protein. (408 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa)
Sros_2137Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1245 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (268 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (569 aa)
Sros_2555KEGG: dvm:DvMF_0572 threonine aldolase. (352 aa)
Sros_2587Cystathionine gamma-synthase; KEGG: cko:CKO_04984 hypothetical protein. (390 aa)
Sros_2589KEGG: mlo:mlr3510 threonine dehydratase. (303 aa)
Sros_2740KEGG: bsu:BSU02410 homocysteine methyltransferase. (287 aa)
Sros_2788KEGG: afw:Anae109_2667 5,10- methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (310 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa)
Sros_3052KEGG: vei:Veis_4212 thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family. (584 aa)
Sros_3143Aminotransferase; KEGG: bsu:BSU31440 aminotransferase. (381 aa)
Sros_3752KEGG: bbt:BBta_0633 putative cysteine synthase (O- acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSase). (351 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (579 aa)
Sros_4119KEGG: aca:ACP_1470 threonine dehydratase catabolic. (319 aa)
Sros_4372KEGG: mrd:Mrad2831_1541 pyridoxal-5'-phosphate- dependent protein beta subunit. (392 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (451 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (302 aa)
Sros_5917Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1154 aa)
dapDPutative tetrahydrodipicolinate N- succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (325 aa)
Sros_6148KEGG: sde:Sde_3057 branched chain amino acid aminotransferase. (276 aa)
dapA-2Dihydrodipicolinate synthase family protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (288 aa)
Sros_6569KEGG: mxa:MXAN_3751 aminotransferase, classes I and II. (394 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
metE5-methyltetrahydropteroyltriglutamate--homocyste ineS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (738 aa)
ilvDKEGG: nmn:NMCC_1068 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa)
Sros_7680Hippurate hydrolase; KEGG: sal:Sala_2314 peptidase M20D, amidohydrolase. (399 aa)
Sros_8009KEGG: sfu:Sfum_2670 cystathionine gamma-synthase. (406 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (459 aa)
Sros_8038KEGG: scl:sce3734 putative alpha- isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (525 aa)
Sros_8041KEGG: nar:Saro_2671 branched-chain amino acid aminotransferase. (364 aa)
Sros_8042KEGG: sfu:Sfum_3031 isocitrate/isopropylmalate dehydrogenase. (348 aa)
Sros_8047KEGG: dal:Dalk_3379 D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
Sros_8058KEGG: gur:Gura_3719 acetolactate synthase 3 regulatory subunit. (174 aa)
Sros_8059KEGG: ade:Adeh_1978 acetolactate synthase, large subunit. (578 aa)
Sros_8078KEGG: mxa:MXAN_1973 hypothetical protein. (334 aa)
Sros_8241KEGG: acr:Acry_2572 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (346 aa)
Sros_8313KEGG: scl:sce8127 putative acetolactate synthase; Belongs to the TPP enzyme family. (550 aa)
Sros_8429Dipeptidase; KEGG: scl:sce2952 dipeptidase. (353 aa)
Sros_8431KEGG: bba:Bd1775 2,3,4,5-tetrahydropyridine-2- carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (276 aa)
Sros_8547KEGG: gme:Gmet_3072 threonine dehydratase. (402 aa)
Sros_8563KEGG: afw:Anae109_3845 cystathionine gamma-lyase. (379 aa)
Sros_8566KEGG: scl:sce0438 cystathionine beta-synthase. (456 aa)
Sros_8776MetE; KEGG: dat:HRM2_34760 MetE. (367 aa)
Sros_8789KEGG: sfu:Sfum_0366 adenosylhomocysteinase. (386 aa)
Sros_8913KEGG: aca:ACP_3389 threonine synthase. (429 aa)
Sros_89855 10-methylenetetrahydrofolate reductase-like protein; KEGG: gur:Gura_1171 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (259 aa)
Sros_9103KEGG: msl:Msil_2816 thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family. (577 aa)
Sros_9310KEGG: pca:Pcar_1903 aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa)
Sros_9311Aspartate kinase; KEGG: dat:HRM2_35870 LysC; Belongs to the aspartokinase family. (424 aa)
Sros_9381KEGG: dvm:DvMF_0572 threonine aldolase. (352 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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