STRINGSTRING
Sros_0267 Sros_0267 Sros_0347 Sros_0347 folD folD purD purD purA purA pyrE pyrE Sros_0798 Sros_0798 guaB guaB Sros_1161 Sros_1161 guaA guaA purN purN purH purH folD-2 folD-2 purK purK purE purE purC purC glyA glyA gcvH gcvH gcvT gcvT Sros_2567 Sros_2567 Sros_2617 Sros_2617 pyrR pyrR pyrB pyrB pyrC pyrC carA carA carB carB Sros_2809 Sros_2809 pyrD pyrD pyrF pyrF gmk gmk def def fmt fmt Sros_2826 Sros_2826 Sros_3464 Sros_3464 Sros_3855 Sros_3855 Sros_3856 Sros_3856 Sros_3857 Sros_3857 Sros_3858 Sros_3858 Sros_3859 Sros_3859 Sros_3925 Sros_3925 Sros_3989 Sros_3989 gcvP gcvP Sros_4439 Sros_4439 apt apt Sros_6635 Sros_6635 Sros_6670 Sros_6670 Sros_7161 Sros_7161 purU purU Sros_7698 Sros_7698 Sros_7699 Sros_7699 Sros_8831 Sros_8831 tdh tdh kbl kbl purS purS purQ purQ purL purL purF purF purM purM pyrD-2 pyrD-2 Sros_9236 Sros_9236
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sros_02675'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase-like protein; KEGG: har:HEAR1476 putative 5'-nucleotidase family protein precursor. (463 aa)
Sros_0347KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. (206 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa)
purDKEGG: gbe:GbCGDNIH1_2297 phosphoribosylamine-- glycine ligase; Belongs to the GARS family. (410 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (178 aa)
Sros_0798KEGG: ret:RHE_CH00088 glycine cleavage system T protein; Belongs to the GcvT family. (822 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
Sros_1161IMP dehydrogenase/GMP reductase-like protein; KEGG: hap:HAPS_0294 inositol-5-monophosphate dehydrogenase. (372 aa)
guaAGMP synthase C terminal domain protein; Catalyzes the synthesis of GMP from XMP. (523 aa)
purNPutative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (206 aa)
purHIMP cyclohydrolase; KEGG: acr:Acry_0027 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (514 aa)
folD-2Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (167 aa)
purCKEGG: psa:PST_2788 phosphoribosylaminoimidazole- succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (276 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (362 aa)
Sros_2567KEGG: afw:Anae109_3412 xanthine/uracil/vitamin C permease. (461 aa)
Sros_2617KEGG: gbm:Gbem_1504 glutamine amidotransferase class-I. (233 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (193 aa)
pyrBAspartate carbamoyltransferase; KEGG: scl:sce3822 hypothetical protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa)
carACarbamoyl-phosphate synthase (glutamine- hydrolyzing); KEGG: hch:HCH_01227 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (400 aa)
carBKEGG: geo:Geob_3271 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1097 aa)
Sros_2809KEGG: pca:Pcar_1295 2-polyprenylphenol hydroxylase/flavodoxin oxidoreductase. (291 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (324 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (234 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (182 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (309 aa)
Sros_2826KEGG: gme:Gmet_0066 Fmu, rRNA SAM-dependent methyltransferase:Nop2p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (515 aa)
Sros_3464KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. (315 aa)
Sros_3855KEGG: dimethylglycine dehydrogenase precursor; Belongs to the GcvT family. (808 aa)
Sros_3856KEGG: rso:RSc1101 sarcosine oxidase subunit beta. (408 aa)
Sros_3857KEGG: xau:Xaut_0868 sarcosine oxidase delta subunit family protein. (92 aa)
Sros_3858KEGG: bmj:BMULJ_05011 sarcosine oxidase alpha subunit; Belongs to the GcvT family. (937 aa)
Sros_3859KEGG: bvi:Bcep1808_7299 sarcosine oxidase, gamma subunit. (190 aa)
Sros_3925KEGG: sil:SPO3529 serine hydroxymethyltransferase. (417 aa)
Sros_39892-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase-like protein; KEGG: afr:AFE_0860 iron-sulfur cluster-binding protein/oxidoreductase, FAD/NAD-binding; Belongs to the globin family. (371 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (951 aa)
Sros_4439KEGG: adenylosuccinate lyase; K01756 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
Sros_6635Hydantoinase; KEGG: bav:BAV0626 hydantoinase. (470 aa)
Sros_6670KEGG: bpt:Bpet3536 putative purine permease. (473 aa)
Sros_7161KEGG: ank:AnaeK_3243 IMP dehydrogenase family protein. (479 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
Sros_7698KEGG: vei:Veis_2458 glycine dehydrogenase subunit 2. (519 aa)
Sros_7699Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (443 aa)
Sros_8831KEGG: sal:Sala_1845 FAD dependent oxidoreductase. (402 aa)
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (342 aa)
kblGlycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (390 aa)
purSPhosphoribosylformylglycinamidine synthase, PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (81 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (227 aa)
purLPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (765 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa)
purMKEGG: mgm:Mmc1_2316 phosphoribosylformylglycinamidine cyclo-ligase. (341 aa)
pyrD-2Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (355 aa)
Sros_9236KEGG: cvi:CV_0803 5-aminolevulinate synthase. (400 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.