node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sros_0347 | Sros_3464 | Sros_0347 | Sros_3464 | KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | 0.915 |
Sros_0347 | folD | Sros_0347 | Sros_0348 | KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.988 |
Sros_0347 | folD-2 | Sros_0347 | Sros_1250 | KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.934 |
Sros_0347 | purU | Sros_0347 | Sros_7341 | KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.906 |
Sros_3464 | Sros_0347 | Sros_3464 | Sros_0347 | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. | 0.915 |
Sros_3464 | folD | Sros_3464 | Sros_0348 | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.959 |
Sros_3464 | folD-2 | Sros_3464 | Sros_1250 | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.950 |
Sros_3464 | glyA | Sros_3464 | Sros_1661 | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
folD | Sros_0347 | Sros_0348 | Sros_0347 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. | 0.988 |
folD | Sros_3464 | Sros_0348 | Sros_3464 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | 0.959 |
folD | folD-2 | Sros_0348 | Sros_1250 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.912 |
folD | glyA | Sros_0348 | Sros_1661 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
folD | purU | Sros_0348 | Sros_7341 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.962 |
folD-2 | Sros_0347 | Sros_1250 | Sros_0347 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: mpt:Mpe_A3258 formimidoyltetrahydrofolate cyclodeaminase. | 0.934 |
folD-2 | Sros_3464 | Sros_1250 | Sros_3464 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | 0.950 |
folD-2 | folD | Sros_1250 | Sros_0348 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.912 |
folD-2 | glyA | Sros_1250 | Sros_1661 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
folD-2 | purU | Sros_1250 | Sros_7341 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.961 |
glyA | Sros_3464 | Sros_1661 | Sros_3464 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | KEGG: efe:EFER_0914 fused UDP-L-Ara4N formyltransferase; UDP-GlcA C-4'-decarboxylase. | 0.928 |
glyA | folD | Sros_1661 | Sros_0348 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.974 |