STRINGSTRING
Sros_0004 Sros_0004 Sros_0391 Sros_0391 Sros_0616 Sros_0616 Sros_0660 Sros_0660 Sros_0661 Sros_0661 Sros_0733 Sros_0733 lipB lipB Sros_1005 Sros_1005 Sros_1175 Sros_1175 sucC sucC sucD sucD Sros_1252 Sros_1252 Sros_1254 Sros_1254 mdh mdh Sros_1285 Sros_1285 ppc ppc Sros_1706 Sros_1706 Sros_2205 Sros_2205 Sros_2206 Sros_2206 Sros_2207 Sros_2207 Sros_2347 Sros_2347 lipA lipA lipB-2 lipB-2 Sros_2644 Sros_2644 Sros_2645 Sros_2645 Sros_2754 Sros_2754 pfp pfp Sros_2830 Sros_2830 Sros_2953 Sros_2953 Sros_3354 Sros_3354 Sros_3371 Sros_3371 edd edd zwf zwf Sros_3924 Sros_3924 Sros_3959 Sros_3959 Sros_3976 Sros_3976 Sros_4316 Sros_4316 Sros_5147 Sros_5147 Sros_5380 Sros_5380 Sros_5411 Sros_5411 Sros_5418 Sros_5418 Sros_5743 Sros_5743 Sros_5845 Sros_5845 Sros_6013 Sros_6013 tal tal Sros_6015 Sros_6015 zwf-2 zwf-2 Sros_6017 Sros_6017 pgl pgl tpiA tpiA pgk pgk Sros_6038 Sros_6038 rbsK-2 rbsK-2 Sros_6420 Sros_6420 Sros_6743 Sros_6743 Sros_6843 Sros_6843 Sros_6844 Sros_6844 Sros_6845 Sros_6845 Sros_7043 Sros_7043 Sros_7320 Sros_7320 Sros_7727 Sros_7727 Sros_8238 Sros_8238 Sros_8284 Sros_8284 Sros_8298 Sros_8298 Sros_8456 Sros_8456 Sros_8457 Sros_8457 Sros_8458 Sros_8458 Sros_8463 Sros_8463 Sros_8464 Sros_8464 Sros_8465 Sros_8465 Sros_8487 Sros_8487 Sros_8500 Sros_8500 fumC fumC pckG pckG eno eno prs prs Sros_8972 Sros_8972 Sros_8973 Sros_8973 Sros_8974 Sros_8974
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sros_0004KEGG: dde:Dde_3470 6-phosphogluconate dehydrogenase- like protein. (313 aa)
Sros_0391Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa)
Sros_0616KEGG: nwi:Nwi_1813 dihydrolipoamide dehydrogenase. (466 aa)
Sros_0660KEGG: eba:ebA3150 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (348 aa)
Sros_0661KEGG: afw:Anae109_1891 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (617 aa)
Sros_0733KEGG: eba:ebA3224 putative ribose-phosphate pyrophosphokinase. (314 aa)
lipBLipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (215 aa)
Sros_1005KEGG: mlo:mll3842 citrate synthase 2; Belongs to the citrate synthase family. (368 aa)
Sros_1175KEGG: sus:Acid_1786 succinic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (521 aa)
sucCSuccinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
Sros_1252KEGG: aca:ACP_1789 citrate synthase 2; Belongs to the citrate synthase family. (373 aa)
Sros_1254KEGG: oca:OCAR_5440 isocitrate dehydrogenase, NADP- dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
Sros_1285KEGG: msl:Msil_0522 dihydrolipoamide dehydrogenase. (464 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (879 aa)
Sros_1706Malate dehydrogenase (oxaloacetate- decarboxylating); KEGG: sat:SYN_00517 NAD-dependent malic enzyme. (470 aa)
Sros_2205KEGG: gsu:GSU3019 dehydrogenase, E1 component, alpha and beta subunits. (307 aa)
Sros_2206Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
Sros_2207Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; KEGG: nmu:Nmul_A0856 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. (417 aa)
Sros_2347KEGG: bba:Bd1150 pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (880 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (309 aa)
lipB-2Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (225 aa)
Sros_2644KEGG: sus:Acid_0914 dihydrolipoyllysine-residue succinyltransferase. (479 aa)
Sros_2645KEGG: mxa:MXAN_4219 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase. (459 aa)
Sros_2754KEGG: sus:Acid_6335 hypothetical protein. (314 aa)
pfpDiphosphate--fructose-6-phosphate1-phosphotransf erase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa)
Sros_2830Ribulose-phosphate 3-epimerase; KEGG: gme:Gmet_0067 ribulose-5-phosphate 3- epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
Sros_2953KEGG: mxa:MXAN_6299 pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa)
Sros_3354KEGG: dar:Daro_2777 2-oxoacid ferredoxin oxidoreductase. (1155 aa)
Sros_3371KEGG: avi:Avi_3816 keto-hydroxyglutarate- aldolase/keto-deoxy-phosphogluconate aldolase. (203 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (626 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
Sros_3924KEGG: aba:Acid345_0377 succinate-semialdehyde dehydrogenase (NAD(P)+). (457 aa)
Sros_39596-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
Sros_3976Gluconokinase; KEGG: afw:Anae109_0595 carbohydrate kinase. (237 aa)
Sros_4316KEGG: aba:Acid345_2541 glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
Sros_5147KEGG: mxa:MXAN_6800 phosphoenolpyruvate synthase. (414 aa)
Sros_5380KEGG: aba:Acid345_0466 carbamoyl-phosphate synthase L chain, ATP-binding. (1829 aa)
Sros_5411KEGG: gme:Gmet_1148 FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (459 aa)
Sros_5418Phosphoketolase; KEGG: neu:NE2135 putative phosphoketolase. (771 aa)
Sros_5743KEGG: lch:Lcho_2003 succinic semialdehyde dehydrogenase. (477 aa)
Sros_5845KEGG: mxa:MXAN_0278 mercuric reductase, truncated. (470 aa)
Sros_6013Tkt1; KEGG: dat:HRM2_48140 Tkt1; Belongs to the transketolase family. (723 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (367 aa)
Sros_6015KEGG: sfu:Sfum_1952 phosphoglucose isomerase (PGI); Belongs to the GPI family. (542 aa)
zwf-2Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (545 aa)
Sros_6017KEGG: sus:Acid_5280 glucose-6-P dehydrogenase subunit-like protein. (303 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (257 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa)
pgkKEGG: bsu:BSU33930 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
Sros_6038KEGG: sus:Acid_7375 glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
rbsK-2Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (299 aa)
Sros_6420KEGG: hch:HCH_06123 2-oxoisovalerate dehydrogenase. (736 aa)
Sros_6743Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa)
Sros_6843KEGG: gsu:GSU3019 dehydrogenase, E1 component, alpha and beta subunits. (330 aa)
Sros_6844Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
Sros_6845KEGG: cko:CKO_03853 hypothetical protein. (396 aa)
Sros_7043Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
Sros_7320KEGG: gme:Gmet_2621 ribose/galactose isomerase. (169 aa)
Sros_7727KEGG: bvi:Bcep1808_1677 ribokinase-like domain- containing protein. (314 aa)
Sros_8238KEGG: vei:Veis_2020 carbohydrate kinase, FGGY. (492 aa)
Sros_8284KEGG: sus:Acid_5307 alpha-ketoglutarate decarboxylase. (1241 aa)
Sros_8298KEGG: bha:BH3168 malic enzyme (malate dehydrogenase). (397 aa)
Sros_8456KEGG: scl:sce6555 succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (245 aa)
Sros_8457KEGG: sus:Acid_7402 succinate dehydrogenase flavoprotein subunit. (642 aa)
Sros_8458KEGG: aca:ACP_0103 succinate dehydrogenase, cytochrome b subunit. (253 aa)
Sros_8463KEGG: aba:Acid345_1383 putative integral membrane protein. (261 aa)
Sros_8464KEGG: aba:Acid345_1384 succinate dehydrogenase flavoprotein subunit. (630 aa)
Sros_8465KEGG: aba:Acid345_1385 fumarate reductase iron- sulfur subunit. (253 aa)
Sros_8487Fructose-bisphosphatase; KEGG: dat:HRM2_21890 GlpX. (344 aa)
Sros_8500Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (550 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)
Sros_8972KEGG: bba:Bd0779 pyruvate dehydrogenase E2. (482 aa)
Sros_8973KEGG: ade:Adeh_1826 branched-chain alpha-keto acid dehydrogenase E1 component. (327 aa)
Sros_8974Pyruvate dehydrogenase (acetyl-transferring); KEGG: gme:Gmet_2509 dehydrogenase, E1 component. (363 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.