STRINGSTRING
clpB clpB Sros_0526 Sros_0526 dnaJ dnaJ grpE grpE dnaK dnaK Sros_0979 Sros_0979 groS groS groL groL Sros_1289 Sros_1289 Sros_1290 Sros_1290 clpS clpS Sros_2038 Sros_2038 Sros_2248 Sros_2248 hrcA hrcA dnaJ-2 dnaJ-2 Sros_2291 Sros_2291 Sros_2499 Sros_2499 Sros_2620 Sros_2620 Sros_2744 Sros_2744 lon lon Sros_3287 Sros_3287 clpP clpP clpX clpX Sros_3653 Sros_3653 dnaK-2 dnaK-2 grpE-2 grpE-2 Sros_4024 Sros_4024 Sros_4025 Sros_4025 clpB-2 clpB-2 Sros_4027 Sros_4027 Sros_4028 Sros_4028 Sros_4118 Sros_4118 Sros_4294 Sros_4294 Sros_4295 Sros_4295 groL-2 groL-2 Sros_4816 Sros_4816 ftsH ftsH Sros_5187 Sros_5187 Sros_5580 Sros_5580 Sros_5718 Sros_5718 Sros_5960 Sros_5960 Sros_5965 Sros_5965 Sros_6021 Sros_6021 ahpD ahpD Sros_6566 Sros_6566 Sros_6567 Sros_6567 Sros_6756 Sros_6756 Sros_7035 Sros_7035 ftsH-2 ftsH-2 clpX-2 clpX-2 clpP-2 clpP-2 clpP-3 clpP-3 Sros_7975 Sros_7975 Sros_8508 Sros_8508 clpP-4 clpP-4 Sros_8639 Sros_8639 groL-3 groL-3 Sros_9148 Sros_9148 Sros_9376 Sros_9376 Sros_9377 Sros_9377
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
clpBATPase AAA-2; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (860 aa)
Sros_0526KEGG: nis:NIS_0956 MerR family transcriptional regulator. (115 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (396 aa)
grpECo-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] (193 aa)
dnaKClass I heat-shock protein (chaperonin); Acts as a chaperone; Belongs to the heat shock protein 70 family. (623 aa)
Sros_0979ATP-dependent protease Clp ATPase subunit-like protein; KEGG: bba:Bd3753 ATP-dependent protease ATP-binding subunit. (123 aa)
groSCo-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (103 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
Sros_1289Molecular chaperone (small heat shock protein)- like protein; KEGG: dal:Dalk_1980 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (148 aa)
Sros_1290KEGG: nam:NAMH_1237 transcriptional regulator, MerR family. (103 aa)
clpSConserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (95 aa)
Sros_2038KEGG: aca:ACP_2711 pyridine nucleotide-disulphide oxidoreductase. (554 aa)
Sros_2248Hypothetical protein. (310 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (337 aa)
dnaJ-2Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] (380 aa)
Sros_2291Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (243 aa)
Sros_2499Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. (106 aa)
Sros_2620KEGG: swi:Swit_0952 hypothetical protein. (296 aa)
Sros_2744KEGG: mrd:Mrad2831_4692 ferritin Dps family protein; Belongs to the Dps family. (155 aa)
lonEndopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (789 aa)
Sros_3287Thioredoxin; KEGG: mxa:MXAN_6848 thioredoxin; Belongs to the thioredoxin family. (123 aa)
clpPEndopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (192 aa)
clpXATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (431 aa)
Sros_3653KEGG: hypothetical protein. (407 aa)
dnaK-2Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (633 aa)
grpE-2GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (176 aa)
Sros_4024KEGG: tgr:Tgr7_2956 heat shock protein DnaJ domain- containing protein. (316 aa)
Sros_4025Hypothetical protein; KEGG: sfu:Sfum_0262 putative transcriptional regulator, MerR family. (106 aa)
clpB-2ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (868 aa)
Sros_4027Thioredoxin; KEGG: sus:Acid_0694 thioredoxin. (148 aa)
Sros_4028Thioredoxin-disulfide reductase; KEGG: sus:Acid_1030 cyclic nucleotide-regulated FAD- dependent pyridine nucleotide-disulphide oxidoreductase. (538 aa)
Sros_4118Membrane protease subunits stomatin/prohibitin; KEGG: gbm:Gbem_2520 band 7 protein. (308 aa)
Sros_4294Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family-like protein; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (252 aa)
Sros_4295Hypothetical protein. (184 aa)
groL-2Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
Sros_4816Molecular chaperone (small heat shock protein)- like protein; KEGG: mes:Meso_2276 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (143 aa)
ftsHMicrotubule-severing ATPase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (641 aa)
Sros_5187KEGG: scl:sce8911 class-V aminotransferase. (395 aa)
Sros_5580KEGG: gdj:Gdia_1145 PEBP family protein. (173 aa)
Sros_5718Molecular chaperone HSP90 family-like protein; KEGG: mxa:MXAN_1393 ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (872 aa)
Sros_5960Molecular chaperone GrpE (heat shock protein)- like protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the re [...] (341 aa)
Sros_5965Molecular chaperone-like protein; KEGG: sus:Acid_6320 heat shock protein 70. (861 aa)
Sros_6021KEGG: hypothetical protein; K03696 ATP-dependent Clp protease ATP-binding subunit ClpC. (196 aa)
ahpDPeroxiredoxin; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. (178 aa)
Sros_6566KEGG: aca:ACP_3043 alkylhydroperoxide reductase C. (183 aa)
Sros_6567KEGG: rce:RC1_0438 hydrogen peroxide-inducible genes activator protein; Belongs to the LysR transcriptional regulatory family. (314 aa)
Sros_6756ATPase with chaperone activity ATP-binding subunit-like protein; KEGG: bha:BH0103 class III stress response-related ATPase. (250 aa)
Sros_7035Hypothetical protein. (499 aa)
ftsH-2Microtubule-severing ATPase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (663 aa)
clpX-2ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
clpP-2Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (214 aa)
clpP-3Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (214 aa)
Sros_7975Cu/Zn superoxide dismutase-like protein; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (226 aa)
Sros_8508Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (202 aa)
clpP-4Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (196 aa)
Sros_8639KEGG: ClpP5; chloroplast Clp protease, subunit of ClpP peptidase complex; K01358 ATP-dependent Clp protease, protease subunit; Belongs to the peptidase S14 family. (208 aa)
groL-3Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
Sros_9148KEGG: bha:BH0103 class III stress response-related ATPase; Belongs to the ClpA/ClpB family. (835 aa)
Sros_9376KEGG: ank:AnaeK_4061 thioredoxin reductase. (310 aa)
Sros_9377Thioredoxin; KEGG: xau:Xaut_3301 thioredoxin; Belongs to the thioredoxin family. (107 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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