STRINGSTRING
Sros_0002 Sros_0002 recF recF Sros_0006 Sros_0006 gyrB gyrB gyrA gyrA Sros_1236 Sros_1236 Sros_1719 Sros_1719 Sros_1792 Sros_1792 recA recA recX recX Sros_2278 Sros_2278 Sros_2311 Sros_2311 recO recO dnaG dnaG Sros_2682 Sros_2682 priA priA dinB dinB Sros_2892 Sros_2892 polA polA uvrB uvrB recD2 recD2 Sros_3676 Sros_3676 Sros_3860 Sros_3860 Sros_4325 Sros_4325 recD2-2 recD2-2 Sros_5632 Sros_5632 Sros_5853 Sros_5853 uvrC uvrC uvrA uvrA Sros_6056 Sros_6056 Sros_6065 Sros_6065 ruvB ruvB ruvA ruvA ruvC ruvC Sros_6116 Sros_6116 Sros_6451 Sros_6451 sbcD sbcD Sros_6530 Sros_6530 Sros_6678 Sros_6678 Sros_6679 Sros_6679 Sros_6926 Sros_6926 Sros_7074 Sros_7074 Sros_7080 Sros_7080 Sros_7084 Sros_7084 lexA lexA Sros_7360 Sros_7360 Sros_7895 Sros_7895 Sros_8000 Sros_8000 Sros_8359 Sros_8359 Sros_8376 Sros_8376 Sros_8377 Sros_8377 xseA xseA xseB xseB mfd mfd Sros_8604 Sros_8604 Sros_8689 Sros_8689 Sros_9062 Sros_9062 radA radA Sros_9146 Sros_9146 Sros_9220 Sros_9220 topA topA recR recR dnaX dnaX Sros_9328 Sros_9328 Sros_9348 Sros_9348 Sros_9356 Sros_9356
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Sros_0002DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] (379 aa)
recFRecombinational DNA repair ATPase (RecF pathway)- like protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (390 aa)
Sros_0006Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives-like protein; KEGG: geo:Geob_1482 protein of unknown function DUF721. (206 aa)
gyrBDNA topoisomerase (ATP-hydrolyzing); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...] (647 aa)
gyrADNA topoisomerase (ATP-hydrolyzing); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...] (836 aa)
Sros_1236KEGG: bsu:BSU06610 ATP-dependent DNA helicase. (762 aa)
Sros_1719DNA or RNA helicase of superfamily II-like protein; KEGG: sde:Sde_1925 GGDEF family protein. (582 aa)
Sros_1792KEGG: ppw:PputW619_2496 excinuclease ABC, A subunit. (824 aa)
recARecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (366 aa)
recXConserved hypothetical protein; Modulates RecA activity; Belongs to the RecX family. (220 aa)
Sros_2278KEGG: gsu:GSU2207 DNA polymerase III, delta subunit, putative. (327 aa)
Sros_2311KEGG: cvi:CV_4236 MerR family transcriptional regulator. (399 aa)
recODNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (245 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (616 aa)
Sros_2682KEGG: cti:RALTA_B0605 DNA polymerase III, epsilon subunit + GIY-YIG endonuclease (modular protein). (574 aa)
priAPrimosomal protein N' (replication factor Y) - superfamily II helicase-like protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (695 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (406 aa)
Sros_2892KEGG: sat:SYN_00896 DNA polymerase III alpha subunit. (1173 aa)
polADNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (901 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (711 aa)
recD2Exodeoxyribonuclease V; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (720 aa)
Sros_3676KEGG: xac:XAC1186 excinuclease ABC subunit A. (880 aa)
Sros_3860DNA polymerase III epsilon subunit and related 3'-5' exonuclease-like protein; KEGG: lhk:LHK_02526 probable DNA-directed DNA polymerase III. (407 aa)
Sros_4325KEGG: acp:A2cp1_2336 DNA polymerase III, alpha subunit; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1152 aa)
recD2-2Exodeoxyribonuclease V; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (738 aa)
Sros_5632KEGG: sus:Acid_0740 ATP-dependent DNA helicase RecQ. (545 aa)
Sros_5853DNA polymerase I; KEGG: pca:Pcar_2864 DNA polymerase I. (306 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (649 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (946 aa)
Sros_6056DNA repair and genetic recombination; May be involved in recombinational repair of damaged DNA. (570 aa)
Sros_6065Hypothetical protein. (179 aa)
ruvBHolliday junction DNA helicase B; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (352 aa)
ruvAHolliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (206 aa)
ruvCCrossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (200 aa)
Sros_6116KEGG: gme:Gmet_0743 hypothetical protein. (250 aa)
Sros_6451KEGG: ade:Adeh_0433 exonuclease SbcC. (1291 aa)
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (375 aa)
Sros_6530KEGG: mxa:MXAN_6717 putative ATP-dependent helicase. (674 aa)
Sros_6678DNA polymerase I - 3'-5' exonuclease and polymerase domains-like protein; KEGG: met:M446_0678 DNA polymerase I. (531 aa)
Sros_6679Hypothetical protein; KEGG: scl:sce2632 calcineurin-like phosphoesterase family protein. (502 aa)
Sros_6926KEGG: bav:BAV2781 ATP-dependent DNA helicase. (628 aa)
Sros_7074KEGG: maq:Maqu_0559 ATP-dependent DNA helicase RecQ. (689 aa)
Sros_7080KEGG: baa:BA_0601 DNA gyrase/topoisomerase IV, subunit A. (831 aa)
Sros_7084DNA topoisomerase (ATP-hydrolyzing); KEGG: bha:BH0006 DNA gyrase subunit B. (690 aa)
lexARepressor lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (236 aa)
Sros_7360KEGG: rso:RSc0422 single-strand DNA-binding protein. (233 aa)
Sros_7895KEGG: scl:sce6315 excinuclease ABC subunit A. (768 aa)
Sros_8000KEGG: tgr:Tgr7_3183 ATP-dependent DNA helicase RecG. (723 aa)
Sros_8359Superfamily I DNA and RNA helicase-like protein; KEGG: gsu:GSU3411 ATP-dependent DNA helicase PcrA, putative. (689 aa)
Sros_8376Superfamily I DNA and RNA helicase-like protein; KEGG: vei:Veis_3742 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1228 aa)
Sros_8377Superfamily I DNA and RNA helicase-like protein; KEGG: afw:Anae109_3440 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1051 aa)
xseAExodeoxyribonuclease VII; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (402 aa)
xseBExonuclease VII small subunit-like protein; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (97 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1204 aa)
Sros_8604KEGG: hch:HCH_04219 hypothetical protein. (167 aa)
Sros_8689KEGG: rpe:RPE_2170 hypothetical protein. (663 aa)
Sros_9062KEGG: tcx:Tcr_0930 DNA polymerase III, epsilon subunit. (189 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (466 aa)
Sros_9146A/G-specific DNA glycosylase-like protein; KEGG: msl:Msil_1600 A/G-specific adenine glycosylase. (291 aa)
Sros_9220KEGG: pca:Pcar_1692 DNA polymerase III, gamma/tau subunits. (393 aa)
topADNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...] (883 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
dnaXDNA-directed DNA polymerase; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (727 aa)
Sros_9328DNA-directed DNA polymerase; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of repl [...] (365 aa)
Sros_9348Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (451 aa)
Sros_9356KEGG: bmn:BMA10247_2957 single-stranded DNA-binding protein. (191 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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