STRINGSTRING
Sros_1634 Sros_1634 argB argB argG-2 argG-2 Sros_9311 Sros_9311 Sros_9310 Sros_9310 Sros_9259 Sros_9259 Sros_9227 Sros_9227 Sros_9200 Sros_9200 panD panD Sros_9151 Sros_9151 Sros_9103 Sros_9103 Sros_8913 Sros_8913 Sros_8912 Sros_8912 Sros_8776 Sros_8776 Sros_8654 Sros_8654 Sros_8566 Sros_8566 Sros_8563 Sros_8563 Sros_8547 Sros_8547 Sros_8431 Sros_8431 Sros_8429 Sros_8429 Sros_8385 Sros_8385 Sros_8366 Sros_8366 Sros_8330 Sros_8330 aroA aroA Sros_8313 Sros_8313 Sros_8265 Sros_8265 Sros_8241 Sros_8241 Sros_8078 Sros_8078 Sros_8059 Sros_8059 Sros_0061 Sros_0061 pheA pheA serS serS Sros_0327 Sros_0327 egtD egtD folD folD pat pat Sros_8041 Sros_8041 Sros_8038 Sros_8038 leuC leuC leuD leuD Sros_8009 Sros_8009 Sros_7984 Sros_7984 Sros_7858 Sros_7858 Sros_7851 Sros_7851 Sros_7849 Sros_7849 Sros_7680 Sros_7680 Sros_7561 Sros_7561 Sros_7497 Sros_7497 Sros_7402 Sros_7402 ilvD ilvD proB proB proA proA metE metE Sros_7214 Sros_7214 Sros_7196 Sros_7196 Sros_7185 Sros_7185 Sros_7152 Sros_7152 trpD-2 trpD-2 Sros_6984 Sros_6984 Sros_6982 Sros_6982 Sros_6952 Sros_6952 Sros_6820 Sros_6820 Sros_6748 Sros_6748 Sros_6725 Sros_6725 glyA-2 glyA-2 aroC aroC aroK-2 aroK-2 aroB aroB aroQ-2 aroQ-2 Sros_6500 Sros_6500 Sros_6183 Sros_6183 dapD dapD Sros_6090 Sros_6090 argC argC argJ argJ Sros_0440 Sros_0440 Sros_0500 Sros_0500 proC proC Sros_0542 Sros_0542 Sros_0724 Sros_0724 Sros_0841 Sros_0841 serC serC Sros_1023 Sros_1023 Sros_1141 Sros_1141 folD-2 folD-2 Sros_1268 Sros_1268 Sros_1518 Sros_1518 Sros_8042 Sros_8042 Sros_8047 Sros_8047 ilvC ilvC Sros_8058 Sros_8058 Sros_2030 Sros_2030 Sros_1779 Sros_1779 Sros_1760 Sros_1760 Sros_1728 Sros_1728 Sros_1727 Sros_1727 Sros_1725 Sros_1725 glyA glyA thrB thrB Sros_1649 Sros_1649 Sros_1638 Sros_1638 lysA lysA Sros_3160 Sros_3160 Sros_3052 Sros_3052 Sros_2998 Sros_2998 Sros_2997 Sros_2997 Sros_2950 Sros_2950 Sros_2949 Sros_2949 trpA trpA trpB trpB trpC trpC hisI hisI Sros_2916 Sros_2916 hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD carB carB carA carA Sros_2799 Sros_2799 Sros_2788 Sros_2788 Sros_2740 Sros_2740 trpD trpD Sros_2629 Sros_2629 Sros_2611 Sros_2611 Sros_2589 Sros_2589 Sros_2587 Sros_2587 Sros_2502 Sros_2502 Sros_2367 Sros_2367 Sros_2361 Sros_2361 Sros_2330 Sros_2330 leuA leuA dapF dapF Sros_2137 Sros_2137 Sros_2136 Sros_2136 dapB dapB Sros_2040 Sros_2040 Sros_3264 Sros_3264 Sros_3288 Sros_3288 edd edd Sros_3531 Sros_3531 Sros_3534 Sros_3534 trpF trpF Sros_3604 Sros_3604 Sros_3644 Sros_3644 Sros_3665 Sros_3665 Sros_3696 Sros_3696 selD selD Sros_3752 Sros_3752 Sros_3753 Sros_3753 Sros_3775 Sros_3775 leuA-2 leuA-2 aroK aroK Sros_3848 Sros_3848 Sros_3889 Sros_3889 Sros_3925 Sros_3925 Sros_4096 Sros_4096 Sros_4119 Sros_4119 Sros_4169 Sros_4169 Sros_4224 Sros_4224 Sros_4248 Sros_4248 Sros_4372 Sros_4372 Sros_4493 Sros_4493 Sros_4565 Sros_4565 Sros_4607 Sros_4607 Sros_4799 Sros_4799 Sros_4855 Sros_4855 Sros_4921 Sros_4921 trpB-2 trpB-2 trpA-2 trpA-2 Sros_4971 Sros_4971 Sros_5171 Sros_5171 Sros_5198 Sros_5198 Sros_5213 Sros_5213 Sros_5214 Sros_5214 Sros_5254 Sros_5254 aroQ aroQ Sros_5431 Sros_5431 Sros_5539 Sros_5539 Sros_5566 Sros_5566 lysA-2 lysA-2 Sros_5592 Sros_5592 ilvE ilvE Sros_5654 Sros_5654 Sros_5703 Sros_5703 Sros_5832 Sros_5832 Sros_5917 Sros_5917 Sros_5957 Sros_5957 hisG hisG hisE hisE argH argH argG argG argR argR Sros_6073 Sros_6073 argD argD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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gene neighborhood
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Sros_1634Hypothetical protein; KEGG: acp:A2cp1_2970 asparagine synthase. (552 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (322 aa)
argG-2KEGG: lch:Lcho_0912 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (482 aa)
Sros_9311Aspartate kinase; KEGG: dat:HRM2_35870 LysC; Belongs to the aspartokinase family. (424 aa)
Sros_9310KEGG: pca:Pcar_1903 aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa)
Sros_9259KEGG: bur:Bcep18194_C7217 GCN5-related N- acetyltransferase. (170 aa)
Sros_9227Peptidase M20; KEGG: dal:Dalk_4445 peptidase M20. (435 aa)
Sros_9200KEGG: gsu:GSU0562 hypothetical protein. (183 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (142 aa)
Sros_9151N-acetylglutamate synthase and related acetyltransferase-like protein; KEGG: pca:Pcar_2325 acetyltransferase; Belongs to the acetyltransferase family. (195 aa)
Sros_9103KEGG: msl:Msil_2816 thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family. (577 aa)
Sros_8913KEGG: aca:ACP_3389 threonine synthase. (429 aa)
Sros_8912Molybdopterin synthase subunit MoaD; KEGG: scl:sce5755 hypothetical protein. (91 aa)
Sros_8776MetE; KEGG: dat:HRM2_34760 MetE. (367 aa)
Sros_8654Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (269 aa)
Sros_8566KEGG: scl:sce0438 cystathionine beta-synthase. (456 aa)
Sros_8563KEGG: afw:Anae109_3845 cystathionine gamma-lyase. (379 aa)
Sros_8547KEGG: gme:Gmet_3072 threonine dehydratase. (402 aa)
Sros_8431KEGG: bba:Bd1775 2,3,4,5-tetrahydropyridine-2- carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (276 aa)
Sros_8429Dipeptidase; KEGG: scl:sce2952 dipeptidase. (353 aa)
Sros_8385KEGG: hch:HCH_02851 molybdopterin/thiamine biosynthesis family protein. (393 aa)
Sros_8366KEGG: pol:Bpro_4782 Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (392 aa)
Sros_8330KEGG: ade:Adeh_1287 histidinol-phosphate phosphatase. (267 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (425 aa)
Sros_8313KEGG: scl:sce8127 putative acetolactate synthase; Belongs to the TPP enzyme family. (550 aa)
Sros_8265KEGG: swi:Swit_2076 dihydrodipicolinate reductase. (352 aa)
Sros_8241KEGG: acr:Acry_2572 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (346 aa)
Sros_8078KEGG: mxa:MXAN_1973 hypothetical protein. (334 aa)
Sros_8059KEGG: ade:Adeh_1978 acetolactate synthase, large subunit. (578 aa)
Sros_0061Homoserine O-acetyltransferase; KEGG: bra:BRADO5867 hypothetical protein; Belongs to the AB hydrolase superfamily. MetX family. (338 aa)
pheAKEGG: ade:Adeh_1779 prephenate dehydratase. (306 aa)
serSSerine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (420 aa)
Sros_0327Succinyl-diaminopimelate desuccinylase; KEGG: dde:Dde_1186 M20/M25/M40 family peptidase. (434 aa)
egtDConserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (326 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa)
patHistidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (353 aa)
Sros_8041KEGG: nar:Saro_2671 branched-chain amino acid aminotransferase. (364 aa)
Sros_8038KEGG: scl:sce3734 putative alpha- isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (525 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (459 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa)
Sros_8009KEGG: sfu:Sfum_2670 cystathionine gamma-synthase. (406 aa)
Sros_7984KEGG: dac:Daci_5156 pyridoxal-5'-phosphate- dependent protein beta subunit. (358 aa)
Sros_7858Hypothetical protein; KEGG: ppg:PputGB1_3631 deaminase-reductase domain- containing protein. (199 aa)
Sros_7851KEGG: oan:Oant_4491 glutamine synthetase catalytic region. (439 aa)
Sros_7849Aminoacylase; KEGG: dvl:Dvul_0678 amidohydrolase. (419 aa)
Sros_7680Hippurate hydrolase; KEGG: sal:Sala_2314 peptidase M20D, amidohydrolase. (399 aa)
Sros_7561Nucleoside phosphorylase-like protein; KEGG: bja:blr0077 hypothetical protein. (296 aa)
Sros_7497Glutamate--ammonia ligase; KEGG: rce:RC1_1466 gamma-glutamylputrescine synthetase; Belongs to the glutamine synthetase family. (445 aa)
Sros_7402Hypothetical protein; KEGG: sme:SM_b20505 putative trifolitoxin immunity protein. (266 aa)
ilvDKEGG: nmn:NMCC_1068 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (429 aa)
metE5-methyltetrahydropteroyltriglutamate--homocyste ineS-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (738 aa)
Sros_7214KEGG: swi:Swit_3995 hypothetical protein. (589 aa)
Sros_7196KEGG: apa:APP7_1355 putative sulfate transport protein CysZ. (249 aa)
Sros_7185KEGG: mxa:MXAN_1250 RibD domain protein. (190 aa)
Sros_7152KEGG: bpt:Bpet0409 D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
trpD-2Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa)
Sros_6984KEGG: bpt:Bpet1887 hypothetical protein. (283 aa)
Sros_6982KEGG: afw:Anae109_3251 deaminase-reductase domain- containing protein. (183 aa)
Sros_6952KEGG: abc:ACICU_01927 dihydrofolate reductase. (178 aa)
Sros_6820Peptidase M20; KEGG: aba:Acid345_0237 peptidase M20. (412 aa)
Sros_6748KEGG: hypothetical protein. (168 aa)
Sros_6725KEGG: mlo:mll3044 hypothetical protein. (376 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (392 aa)
aroK-2Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (358 aa)
aroQ-23-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa)
Sros_6500KEGG: gbm:Gbem_1778 asparagine synthase (glutamine- hydrolyzing). (638 aa)
Sros_6183KEGG: mlo:mlr6716 hypothetical protein. (346 aa)
dapDPutative tetrahydrodipicolinate N- succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (325 aa)
Sros_6090KEGG: bam:Bamb_5913 shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (274 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa)
argJAmino-acid N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (384 aa)
Sros_0440Diaminopimelate decarboxylase-like protein; KEGG: bar:GBAA1438 diaminopimelate decarboxylase. (276 aa)
Sros_0500Phosphoserine phosphatase; KEGG: scl:sce0663 hypothetical protein. (407 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (264 aa)
Sros_0542Phosphoserine phosphatase-like protein; KEGG: afw:Anae109_1214 HAD family hydrolase. (289 aa)
Sros_0724KEGG: scl:sce1370 dihydrofolate reductase family protein. (197 aa)
Sros_0841KEGG: scl:sce6636 hypothetical protein. (189 aa)
serCPhosphoserine aminotransferase-like protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (369 aa)
Sros_1023Bifunctional deaminase-reductase-like protein; KEGG: mes:Meso_2196 bifunctional deaminase- reductase-like. (178 aa)
Sros_1141Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (371 aa)
folD-2Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
Sros_1268Aminoacylase; KEGG: bsu:BSU29290 hypothetical protein. (412 aa)
Sros_1518Peptidase M20; KEGG: ade:Adeh_0863 peptidase M20. (448 aa)
Sros_8042KEGG: sfu:Sfum_3031 isocitrate/isopropylmalate dehydrogenase. (348 aa)
Sros_8047KEGG: dal:Dalk_3379 D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
Sros_8058KEGG: gur:Gura_3719 acetolactate synthase 3 regulatory subunit. (174 aa)
Sros_2030Hypothetical protein; KEGG: vei:Veis_2871 aminoglycoside phosphotransferase. (285 aa)
Sros_1779KEGG: bbr:BB2432 allantoate amidohydrolase. (387 aa)
Sros_1760Glutamate--ammonia ligase; KEGG: acr:Acry_2393 glutamine synthetase, catalytic region. (447 aa)
Sros_1728KEGG: eba:ebA896 cysteine synthase B. (315 aa)
Sros_1727Molybdopterin synthase subunit MoaD; KEGG: scl:sce5755 hypothetical protein. (92 aa)
Sros_1725Mov34/MPN/PAD-1; KEGG: nmu:Nmul_A0971 Mov34/MPN/PAD-1. (138 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (336 aa)
Sros_1649L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
Sros_1638KEGG: gme:Gmet_1629 homoserine dehydrogenase. (430 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (460 aa)
Sros_3160Peptidase M20; KEGG: dal:Dalk_4445 peptidase M20. (421 aa)
Sros_3052KEGG: vei:Veis_4212 thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family. (584 aa)
Sros_2998Prephenate dehydrogenase-like protein; KEGG: bpt:Bpet1887 hypothetical protein. (357 aa)
Sros_2997KEGG: ade:Adeh_0182 chorismate mutase. (119 aa)
Sros_2950KEGG: aba:Acid345_3679 glutamate synthase (NADH) small subunit. (492 aa)
Sros_2949KEGG: afw:Anae109_0854 glutamate synthase (ferredoxin). (1501 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (264 aa)
trpBTryptophan synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa)
trpCKEGG: afw:Anae109_0373 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (269 aa)
hisIPhosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (115 aa)
Sros_2916KEGG: glutamate-ammonia ligase; Belongs to the glutamine synthetase family. (469 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
hisAPhosphoribosylanthranilate isomerase; KEGG: plu:plu0797 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase. (240 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (209 aa)
hisBKEGG: dal:Dalk_3080 imidazoleglycerol-phosphate dehydratase. (206 aa)
hisCKEGG: bur:Bcep18194_C7445 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
carBKEGG: geo:Geob_3271 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1097 aa)
carACarbamoyl-phosphate synthase (glutamine- hydrolyzing); KEGG: hch:HCH_01227 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (400 aa)
Sros_2799Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa)
Sros_2788KEGG: afw:Anae109_2667 5,10- methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (310 aa)
Sros_2740KEGG: bsu:BSU02410 homocysteine methyltransferase. (287 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa)
Sros_2629KEGG: dal:Dalk_5100 glutamine synthetase, type I. (474 aa)
Sros_2611KEGG: sat:SYN_01628 glutamine synthetase. (453 aa)
Sros_2589KEGG: mlo:mlr3510 threonine dehydratase. (303 aa)
Sros_2587Cystathionine gamma-synthase; KEGG: cko:CKO_04984 hypothetical protein. (390 aa)
Sros_2502KEGG: csa:Csal_0030 acetylornithine deacetylase. (418 aa)
Sros_2367Dihydrodipicolinate synthase/N-acetylneuraminate lyase-like protein; KEGG: acp:A2cp1_4217 dihydrodipicolinate synthase. (333 aa)
Sros_2361KEGG: bja:bll4205 hypothetical protein; Belongs to the DapA family. (351 aa)
Sros_2330KEGG: rle:RL4385 ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (403 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (569 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (268 aa)
Sros_2137Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1245 aa)
Sros_2136KEGG: pla:Plav_3174 GCN5-related N- acetyltransferase. (169 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa)
Sros_2040Glutamate--ammonia ligase; KEGG: hypothetical protein; K01915 glutamine synthetase. (337 aa)
Sros_3264KEGG: dac:Daci_3022 deaminase-reductase domain- containing protein. (180 aa)
Sros_3288KEGG: rce:RC1_0952 3-deoxy-7-phosphoheptulonate synthase; Belongs to the class-II DAHP synthase family. (443 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (626 aa)
Sros_3531KEGG: mes:Meso_2469 asparagine synthase (glutamine- hydrolyzing). (596 aa)
Sros_3534KEGG: rlt:Rleg2_4009 D-isomer specific 2- hydroxyacid dehydrogenase NAD-binding. (333 aa)
trpFKEGG: sil:SPO0806 N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (211 aa)
Sros_3604Peptidase M20; KEGG: dal:Dalk_4445 peptidase M20. (434 aa)
Sros_3644KEGG: mlo:mlr0926 hypothetical protein. (190 aa)
Sros_3665KEGG: bsu:BSU37740 hypothetical protein. (187 aa)
Sros_3696KEGG: afw:Anae109_3251 deaminase-reductase domain- containing protein. (181 aa)
selDSelenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (354 aa)
Sros_3752KEGG: bbt:BBta_0633 putative cysteine synthase (O- acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSase). (351 aa)
Sros_3753KEGG: hch:HCH_03695 diaminopimelate decarboxylase. (432 aa)
Sros_37753-deoxy-7-phosphoheptulonate synthase; KEGG: ppf:Pput_3849 phospho-2-dehydro-3- deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (388 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (579 aa)
aroK3-dehydroquinate synthase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa)
Sros_3848KEGG: scl:sce1370 dihydrofolate reductase family protein. (190 aa)
Sros_3889KEGG: swi:Swit_1410 GCN5-related N- acetyltransferase. (131 aa)
Sros_3925KEGG: sil:SPO3529 serine hydroxymethyltransferase. (417 aa)
Sros_4096KEGG: mxa:MXAN_1250 RibD domain protein. (192 aa)
Sros_4119KEGG: aca:ACP_1470 threonine dehydratase catabolic. (319 aa)
Sros_4169Asparagine synthase (glutamine-hydrolyzing); KEGG: scl:sce4939 hypothetical protein. (619 aa)
Sros_4224KEGG: mlo:mlr2503 hypothetical protein. (178 aa)
Sros_4248KEGG: swi:Swit_2076 dihydrodipicolinate reductase. (359 aa)
Sros_4372KEGG: mrd:Mrad2831_1541 pyridoxal-5'-phosphate- dependent protein beta subunit. (392 aa)
Sros_4493Bifunctional deaminase-reductase-like protein; KEGG: rfr:Rfer_2843 bifunctional deaminase- reductase-like. (214 aa)
Sros_4565KEGG: bur:Bcep18194_B1493 serine/threonine dehydratase. (320 aa)
Sros_4607Putative homoserine kinase type II (protein kinase fold)-like protein; KEGG: eli:ELI_14350 tyrosine protein kinase:aminoglycoside phosphotransferase. (294 aa)
Sros_4799Hypothetical protein; KEGG: kpn:KPN_02962 putative bifunctional deaminase- reductase. (89 aa)
Sros_4855Asp/Glu racemase; KEGG: bur:Bcep18194_B2040 Asp/Glu racemase. (258 aa)
Sros_4921Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (167 aa)
trpB-2Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa)
trpA-2Tryptophan synthase; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa)
Sros_4971Cysteine synthase-like protein; KEGG: mlo:mlr9541 cysteine synthase. (379 aa)
Sros_5171KEGG: ret:RHE_PF00444 hypothetical protein. (594 aa)
Sros_5198KEGG: dat:HRM2_29090 hypothetical protein. (251 aa)
Sros_5213KEGG: rec:RHECIAT_PC0000475 putative aminoglycoside phosphotransferase protein (antibiotic resistance protein). (279 aa)
Sros_5214KEGG: afw:Anae109_2478 inositol monophosphatase. (267 aa)
Sros_5254Asparagine synthase (glutamine-hydrolyzing); KEGG: scl:sce4939 hypothetical protein. (597 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (153 aa)
Sros_5431Hypothetical protein; KEGG: bpt:Bpet4090 acetyltransferase. (173 aa)
Sros_5539KEGG: bmn:BMA10247_1403 hypothetical protein. (363 aa)
Sros_5566KEGG: sus:Acid_1483 thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family. (612 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (451 aa)
Sros_5592Sulfite reductase beta subunit (hemoprotein)- like protein; KEGG: pae:PA2906 putative oxidoreductase. (473 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (302 aa)
Sros_5654Hypothetical protein; KEGG: afw:Anae109_3251 deaminase-reductase domain- containing protein. (122 aa)
Sros_5703Peptidase M20; KEGG: aba:Acid345_0237 peptidase M20. (405 aa)
Sros_5832KEGG: sus:Acid_6255 deaminase-reductase domain- containing protein. (187 aa)
Sros_5917Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1154 aa)
Sros_5957KEGG: kpe:KPK_4258 hypothetical protein. (206 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa)
hisEPhosphoribosyl-ATP pyrophosphohydrolase-like protein; KEGG: smt:Smal_1763 phosphoribosyl-ATP diphosphatase. (87 aa)
argHKEGG: pfo:Pfl01_2852 argininosuccinate lyase. (472 aa)
argGKEGG: bha:BH3187 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (167 aa)
Sros_6073Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (338 aa)
argDKEGG: afw:Anae109_2686 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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