STRINGSTRING
psuG psuG Sros_0075 Sros_0075 pheA pheA Sros_0231 Sros_0231 nth nth Sros_0550 Sros_0550 Sros_0551 Sros_0551 Sros_0632 Sros_0632 Sros_0741 Sros_0741 Sros_0947 Sros_0947 nnrD nnrD Sros_1493 Sros_1493 Sros_1498 Sros_1498 Sros_1649 Sros_1649 hutU hutU dapA dapA Sros_2177 Sros_2177 Sros_2361 Sros_2361 Sros_2367 Sros_2367 Sros_2376 Sros_2376 Sros_2378 Sros_2378 Sros_2475 Sros_2475 hisB hisB trpB trpB trpA trpA Sros_3276 Sros_3276 edd edd Sros_3665 Sros_3665 Sros_4372 Sros_4372 Sros_4472 Sros_4472 Sros_4860 Sros_4860 trpB-2 trpB-2 trpA-2 trpA-2 aroQ aroQ murQ murQ Sros_5922 Sros_5922 Sros_6005 Sros_6005 Sros_6245 Sros_6245 dapA-2 dapA-2 Sros_6336 Sros_6336 Sros_6455 Sros_6455 Sros_6490 Sros_6490 Sros_6506 Sros_6506 aroQ-2 aroQ-2 aroB aroB aroC aroC Sros_6625 Sros_6625 Sros_6627 Sros_6627 Sros_6631 Sros_6631 Sros_6725 Sros_6725 Sros_6743 Sros_6743 Sros_6793 Sros_6793 Sros_6915 Sros_6915 Sros_7042 Sros_7042 Sros_7083 Sros_7083 ilvD ilvD dapA-3 dapA-3 vgb vgb Sros_7703 Sros_7703 mutM mutM leuD leuD leuC leuC Sros_8215 Sros_8215 gmd gmd Sros_8352 Sros_8352 Sros_8421 Sros_8421 Sros_8500 Sros_8500 fumC fumC eno eno Sros_8913 Sros_8913 Sros_9112 Sros_9112 Sros_9115 Sros_9115 Sros_9123 Sros_9123 Sros_9131 Sros_9131
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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psuGConserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (312 aa)
Sros_0075KEGG: scl:sce1440 putative terpene cyclase. (745 aa)
pheAKEGG: ade:Adeh_1779 prephenate dehydratase. (306 aa)
Sros_0231KEGG: reh:H16_B0667 acyl dehydratase. (156 aa)
nthDNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (241 aa)
Sros_0550KEGG: gme:Gmet_3235 uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase. (526 aa)
Sros_0551Porphobilinogen synthase; KEGG: sfu:Sfum_3057 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (328 aa)
Sros_0632KEGG: dvm:DvMF_0141 dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (340 aa)
Sros_0741KEGG: afw:Anae109_0390 MaoC-like dehydratase; Belongs to the UPF0336 family. (148 aa)
Sros_0947KEGG: rlt:Rleg2_1526 hypothetical protein. (236 aa)
nnrDYjeF-like protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimer [...] (533 aa)
Sros_1493KEGG: bsu:BSU07560 pectate lyase. (435 aa)
Sros_1498KEGG: csa:Csal_2487 5-dehydro-4-deoxyglucarate dehydratase; Belongs to the DapA family. (291 aa)
Sros_1649L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (551 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa)
Sros_2177KEGG: afw:Anae109_1725 DNA-(apurinic or apyrimidinic site) lyase. (263 aa)
Sros_2361KEGG: bja:bll4205 hypothetical protein; Belongs to the DapA family. (351 aa)
Sros_2367Dihydrodipicolinate synthase/N-acetylneuraminate lyase-like protein; KEGG: acp:A2cp1_4217 dihydrodipicolinate synthase. (333 aa)
Sros_2376KEGG: hypothetical protein. (679 aa)
Sros_2378KEGG: rpb:RPB_0111 enoyl-CoA hydratase. (257 aa)
Sros_2475KEGG: rle:pRL120328 putative dihydropicolinate synthase family protein; Belongs to the DapA family. (309 aa)
hisBKEGG: dal:Dalk_3080 imidazoleglycerol-phosphate dehydratase. (206 aa)
trpBTryptophan synthase; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (414 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (264 aa)
Sros_3276Lyase-like protein; KEGG: bbr:BB0423 putative hydrolase. (377 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (626 aa)
Sros_3665KEGG: bsu:BSU37740 hypothetical protein. (187 aa)
Sros_4372KEGG: mrd:Mrad2831_1541 pyridoxal-5'-phosphate- dependent protein beta subunit. (392 aa)
Sros_4472Secreted hydrolase-like protein; KEGG: avi:Avi_0323 hypothetical protein. (360 aa)
Sros_4860Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (202 aa)
trpB-2Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa)
trpA-2Tryptophan synthase; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (153 aa)
murQN-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (305 aa)
Sros_5922Uroporphyrinogen-III synthase-like protein; KEGG: scl:sce6449 putative transcriptional regulator. (389 aa)
Sros_6005KEGG: mxa:MXAN_6203 dihydrodipicolinate synthase family protein; Belongs to the DapA family. (297 aa)
Sros_6245DNA-(apurinic or apyrimidinic site) lyase; KEGG: aca:ACP_0800 putative formamidopyrimidine-DNA glycosylase. (269 aa)
dapA-2Dihydrodipicolinate synthase family protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (288 aa)
Sros_6336KEGG: pol:Bpro_5294 MaoC-like dehydratase. (172 aa)
Sros_6455KEGG: rce:RC1_0640 enoyl-CoA hydratase. (293 aa)
Sros_6490KEGG: afw:Anae109_4443 dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (325 aa)
Sros_6506KEGG: scl:sce3760 UDP-glucose 4-epimerase. (326 aa)
aroQ-23-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (358 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (392 aa)
Sros_6625KEGG: bur:Bcep18194_B1168 MmgE/PrpD family protein. (447 aa)
Sros_6627KEGG: pla:Plav_0156 hypothetical protein. (158 aa)
Sros_6631KEGG: bpd:BURPS668_A3028 MmgE/PrpD family protein. (468 aa)
Sros_6725KEGG: mlo:mll3044 hypothetical protein. (376 aa)
Sros_6743Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa)
Sros_6793Carbonate dehydratase; KEGG: mxa:MXAN_4784 inorganic anion transporter, sulfate permease (SulP) family. (749 aa)
Sros_6915Pectate lyase-like protein; KEGG: pectate lyase, putative. (482 aa)
Sros_7042KEGG: ank:AnaeK_0986 protein of unknown function UPF0047. (135 aa)
Sros_7083KEGG: scl:sce1313 putative carbonate hydratase. (164 aa)
ilvDKEGG: nmn:NMCC_1068 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa)
dapA-3Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (304 aa)
vgbPutative hydrolase; Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2- amino-butenoic acid. (302 aa)
Sros_7703KEGG: aca:ACP_1052 putative pterin-4-alpha- carbinolamine dehydratase. (96 aa)
mutMDNA-formamidopyrimidine glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (288 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (459 aa)
Sros_8215KEGG: xca:xccb100_4271 phosphopyruvate hydratase; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (431 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (342 aa)
Sros_8352KEGG: mxa:MXAN_6608 enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
Sros_8421KEGG: smd:Smed_4154 enoyl-CoA hydratase. (261 aa)
Sros_8500Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (550 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
Sros_8913KEGG: aca:ACP_3389 threonine synthase. (429 aa)
Sros_9112KEGG: ara:Arad_7266 4-oxalocrotonate decarboxylase. (255 aa)
Sros_9115KEGG: rso:RS01662 putative hydratase protein. (265 aa)
Sros_9123KEGG: scl:sce1698 putative pterin-4-alpha- carbinolamine dehydratase. (112 aa)
Sros_9131KEGG: pde:Pden_3937 transferase hexapeptide protein. (185 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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