STRINGSTRING
Sros_1634 Sros_1634 Sros_1674 Sros_1674 Sros_1722 Sros_1722 Sros_1760 Sros_1760 Sros_2040 Sros_2040 Sros_2077 Sros_2077 nadE nadE Sros_2611 Sros_2611 Sros_2629 Sros_2629 carB carB carA carA Sros_2815 Sros_2815 murE murE murF murF murD murD murC murC Sros_6412 Sros_6412 Sros_2916 Sros_2916 pyrG pyrG Sros_3234 Sros_3234 Sros_3529 Sros_3529 Sros_3531 Sros_3531 Sros_3532 Sros_3532 nadE-2 nadE-2 Sros_3660 Sros_3660 Sros_3798 Sros_3798 Sros_4169 Sros_4169 Sros_4193 Sros_4193 Sros_4298 Sros_4298 Sros_4529 Sros_4529 Sros_5254 Sros_5254 Sros_5590 Sros_5590 pafA pafA cobB cobB mshC mshC argG argG Sros_6279 Sros_6279 Sros_6358 Sros_6358 egtA egtA Sros_6500 Sros_6500 Sros_6856 Sros_6856 Sros_7214 Sros_7214 Sros_7286 Sros_7286 Sros_7497 Sros_7497 Sros_7851 Sros_7851 ddl ddl gatB gatB gatA gatA gatC gatC bioD bioD Sros_8318 Sros_8318 Sros_8363 Sros_8363 Sros_8364 Sros_8364 Sros_8365 Sros_8365 Sros_8650 Sros_8650 Sros_8691 Sros_8691 purA-2 purA-2 purS purS purQ purQ purL purL purM purM Sros_9080 Sros_9080 panC panC tilS tilS argG-2 argG-2 ddl-2 ddl-2 purD purD purA purA Sros_0459 Sros_0459 Sros_0913 Sros_0913 Sros_0914 Sros_0914 guaA guaA Sros_1267 Sros_1267 Sros_1299 Sros_1299 Sros_1326 Sros_1326 purK purK Sros_1379 Sros_1379 purC purC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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Sros_1634Hypothetical protein; KEGG: acp:A2cp1_2970 asparagine synthase. (552 aa)
Sros_1674Hypothetical protein; KEGG: nar:Saro_0591 phosphopantothenate-cysteine ligase / phosphopantothenoylcysteine decarboxylase. (182 aa)
Sros_1722Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (428 aa)
Sros_1760Glutamate--ammonia ligase; KEGG: acr:Acry_2393 glutamine synthetase, catalytic region. (447 aa)
Sros_2040Glutamate--ammonia ligase; KEGG: hypothetical protein; K01915 glutamine synthetase. (337 aa)
Sros_2077KEGG: tmz:Tmz1t_1794 hypothetical protein. (277 aa)
nadENAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (597 aa)
Sros_2611KEGG: sat:SYN_01628 glutamine synthetase. (453 aa)
Sros_2629KEGG: dal:Dalk_5100 glutamine synthetase, type I. (474 aa)
carBKEGG: geo:Geob_3271 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1097 aa)
carACarbamoyl-phosphate synthase (glutamine- hydrolyzing); KEGG: hch:HCH_01227 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (400 aa)
Sros_2815Phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (514 aa)
murFUDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (465 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (465 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (468 aa)
Sros_6412KEGG: rru:Rru_A1941 3-methylcrotonoyl-CoA carboxylase, alpha subunit. (656 aa)
Sros_2916KEGG: glutamate-ammonia ligase; Belongs to the glutamine synthetase family. (469 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (563 aa)
Sros_3234KEGG: mxa:MXAN_2890 hypothetical protein. (402 aa)
Sros_3529Carboxylate-amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (370 aa)
Sros_3531KEGG: mes:Meso_2469 asparagine synthase (glutamine- hydrolyzing). (596 aa)
Sros_3532Conserved hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (837 aa)
nadE-2NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (276 aa)
Sros_3660KEGG: plu:plu1218 hypothetical protein. (411 aa)
Sros_3798KEGG: dac:Daci_5726 carbamoyl-phosphate synthase L chain ATP-binding. (583 aa)
Sros_4169Asparagine synthase (glutamine-hydrolyzing); KEGG: scl:sce4939 hypothetical protein. (619 aa)
Sros_4193KEGG: gdj:Gdia_2052 acetyl-CoA carboxylase, biotin carboxylase. (450 aa)
Sros_4298UDP-N-acetylmuramyl tripeptide synthase-like protein; KEGG: noc:Noc_2865 UDP-N-acetylmuramoylalanyl-D- glutamyl-2,6-diaminopimelate-D-alanyl-D -alanyl ligase. (411 aa)
Sros_4529CTP synthase; KEGG: ent:Ent638_1664 hypothetical protein. (251 aa)
Sros_5254Asparagine synthase (glutamine-hydrolyzing); KEGG: scl:sce4939 hypothetical protein. (597 aa)
Sros_5590KEGG: mmr:Mmar10_2990 hypothetical protein. (279 aa)
pafAHypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (452 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (478 aa)
mshCCysteine--tRNA ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (407 aa)
argGKEGG: bha:BH3187 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
Sros_6279KEGG: mxa:MXAN_1276 glutamate-cysteine ligase, family 2. (478 aa)
Sros_6358KEGG: xau:Xaut_1855 carbamoyl-phosphate synthase L chain ATP-binding. (667 aa)
egtAGlutamate/cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (408 aa)
Sros_6500KEGG: gbm:Gbem_1778 asparagine synthase (glutamine- hydrolyzing). (638 aa)
Sros_6856Hypothetical protein; KEGG: bra:BRADO1272 putative gas vesicle synthesis protein, GvpF/L-like. (270 aa)
Sros_7214KEGG: swi:Swit_3995 hypothetical protein. (589 aa)
Sros_7286KEGG: gur:Gura_3277 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (440 aa)
Sros_7497Glutamate--ammonia ligase; KEGG: rce:RC1_1466 gamma-glutamylputrescine synthetase; Belongs to the glutamine synthetase family. (445 aa)
Sros_7851KEGG: oan:Oant_4491 glutamine synthetase catalytic region. (439 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (369 aa)
gatBaspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (501 aa)
gatAAmidase; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (496 aa)
gatCglutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (99 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (240 aa)
Sros_8318KEGG: bha:BH1132 acetyl-CoA carboxylase biotin carboxylase subunit. (443 aa)
Sros_8363KEGG: reh:PHG125 putative siderophore biosynthesis protein. (401 aa)
Sros_8364KEGG: xcv:XCV3308 putative siderophore biosynthesis protein. (545 aa)
Sros_8365KEGG: reh:PHG122 putative iron transport protein. (519 aa)
Sros_8650KEGG: mrd:Mrad2831_5362 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (193 aa)
Sros_8691Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit-like protein; KEGG: lpc:LPC_0215 hypothetical protein. (944 aa)
purA-2Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (406 aa)
purSPhosphoribosylformylglycinamidine synthase, PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (81 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (227 aa)
purLPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (765 aa)
purMKEGG: mgm:Mmc1_2316 phosphoribosylformylglycinamidine cyclo-ligase. (341 aa)
Sros_9080Uncharacterized enzyme; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (386 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (285 aa)
tilStRNA(Ile)-lysidine synthetase-like protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (337 aa)
argG-2KEGG: lch:Lcho_0912 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (482 aa)
ddl-2D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (318 aa)
purDKEGG: gbe:GbCGDNIH1_2297 phosphoribosylamine-- glycine ligase; Belongs to the GARS family. (410 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
Sros_0459KEGG: vfm:VFMJ11_2362 GatB/YqeY domain protein. (154 aa)
Sros_0913UDP-N-acetylmuramyl tripeptide synthase-like protein; KEGG: aeh:Mlg_2195 UDP-N-acetylmuramoylalanine--D- glutamate ligase. (429 aa)
Sros_0914Glutamine amidotransferase-like protein; KEGG: sal:Sala_2756 cobyric acid synthase CobQ. (238 aa)
guaAGMP synthase C terminal domain protein; Catalyzes the synthesis of GMP from XMP. (523 aa)
Sros_1267KEGG: rpe:RPE_0617 protein of unknown function DUF201. (471 aa)
Sros_1299KEGG: dac:Daci_5726 carbamoyl-phosphate synthase L chain ATP-binding. (579 aa)
Sros_1326KEGG: afw:Anae109_1479 biotin--acetyl-CoA- carboxylase ligase. (274 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa)
Sros_1379Coenzyme F420-0 gamma-glutamyl ligase; KEGG: bpy:Bphyt_4255 F420-dependent oxidoreductase. (439 aa)
purCKEGG: psa:PST_2788 phosphoribosylaminoimidazole- succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (276 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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