STRINGSTRING
Sros_0660 Sros_0660 Sros_4286 Sros_4286 Sros_4372 Sros_4372 Sros_4482 Sros_4482 Sros_4546 Sros_4546 Sros_4565 Sros_4565 Sros_5016 Sros_5016 Sros_5114 Sros_5114 Sros_5566 Sros_5566 lysA-2 lysA-2 Sros_5582 Sros_5582 Sros_5583 Sros_5583 Sros_5610 Sros_5610 Sros_5894 Sros_5894 Sros_5917 Sros_5917 Sros_5956 Sros_5956 argD argD Sros_6239 Sros_6239 Sros_6556 Sros_6556 Sros_6569 Sros_6569 glyA-2 glyA-2 dxs-2 dxs-2 Sros_6842 Sros_6842 Sros_6999 Sros_6999 Sros_7120 Sros_7120 Sros_7678 Sros_7678 Sros_7731 Sros_7731 Sros_8009 Sros_8009 Sros_8059 Sros_8059 Sros_8110 Sros_8110 Sros_8139 Sros_8139 Sros_8249 Sros_8249 Sros_9379 Sros_9379 Sros_9368 Sros_9368 Sros_9291 Sros_9291 Sros_9236 Sros_9236 Sros_9197 Sros_9197 kynU kynU Sros_9103 Sros_9103 Sros_9045 Sros_9045 Sros_8913 Sros_8913 kbl kbl Sros_8815 Sros_8815 Sros_8687 Sros_8687 Sros_8563 Sros_8563 Sros_8547 Sros_8547 Sros_8434 Sros_8434 Sros_8366 Sros_8366 Sros_8313 Sros_8313 Sros_8308 Sros_8308 Sros_8284 Sros_8284 pat pat Sros_0440 Sros_0440 hemL hemL serC serC Sros_1066 Sros_1066 Sros_1141 Sros_1141 Sros_1177 Sros_1177 Sros_1198 Sros_1198 Sros_1242 Sros_1242 Sros_1440 Sros_1440 Sros_1519 Sros_1519 lysA lysA Sros_1649 Sros_1649 glyA glyA Sros_1703 Sros_1703 Sros_1947 Sros_1947 Sros_1956 Sros_1956 Sros_2137 Sros_2137 Sros_2186 Sros_2186 Sros_2208 Sros_2208 Sros_2228 Sros_2228 Sros_2330 Sros_2330 Sros_2420 Sros_2420 Sros_2423 Sros_2423 Sros_2429 Sros_2429 Sros_2586 Sros_2586 Sros_2587 Sros_2587 Sros_2589 Sros_2589 Sros_2669 Sros_2669 Sros_2875 Sros_2875 hisC hisC Sros_3052 Sros_3052 Sros_3086 Sros_3086 Sros_3143 Sros_3143 Sros_3187 Sros_3187 Sros_3188 Sros_3188 Sros_3334 Sros_3334 Sros_3418 Sros_3418 Sros_3468 Sros_3468 icmF icmF Sros_3663 Sros_3663 dxs dxs Sros_3753 Sros_3753 Sros_3766 Sros_3766 Sros_3767 Sros_3767 Sros_3900 Sros_3900 Sros_3925 Sros_3925 menD menD Sros_4068 Sros_4068 Sros_4119 Sros_4119 Sros_4120 Sros_4120
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sros_0660KEGG: eba:ebA3150 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (348 aa)
Sros_4286KEGG: mxa:MXAN_4528 polyketide synthase. (1822 aa)
Sros_4372KEGG: mrd:Mrad2831_1541 pyridoxal-5'-phosphate- dependent protein beta subunit. (392 aa)
Sros_4482KEGG: rpe:RPE_1486 cobalamin B12-binding domain protein. (351 aa)
Sros_4546KEGG: aca:ACP_2295 pyridoxal-dependent decarboxylase conserved domain protein. (472 aa)
Sros_4565KEGG: bur:Bcep18194_B1493 serine/threonine dehydratase. (320 aa)
Sros_5016KEGG: aha:AHA_1495 flavodoxin reductase family 1 protein. (264 aa)
Sros_5114KEGG: mrd:Mrad2831_2878 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (436 aa)
Sros_5566KEGG: sus:Acid_1483 thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family. (612 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (451 aa)
Sros_5582KEGG: gdi:GDI2833 putative nonribosomal peptide synthetases (NPRS). (1654 aa)
Sros_5583Non-ribosomal peptide synthetase modules and related protein-like protein; KEGG: mxa:MXAN_3636 non-ribosomal peptide synthetase. (1806 aa)
Sros_5610Putative transcriptional regulator, GntR family; KEGG: esa:ESA_02823 hypothetical protein. (468 aa)
Sros_5894Aminotransferase; KEGG: nar:Saro_0248 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (407 aa)
Sros_5917Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1154 aa)
Sros_5956KEGG: pzu:PHZ_c3113 transcriptional regulator, GntR family. (486 aa)
argDKEGG: afw:Anae109_2686 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa)
Sros_6239KEGG: hypothetical protein. (1307 aa)
Sros_6556KEGG: bsu:BSU31960 involved in siderophore 2,3- dihydroxybenzoate (DHB) synthesis. (1305 aa)
Sros_6569KEGG: mxa:MXAN_3751 aminotransferase, classes I and II. (394 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
dxs-21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (639 aa)
Sros_6842Non-ribosomal peptide synthetase modules and related protein-like protein; KEGG: mxa:MXAN_4000 non-ribosomal peptide synthetase. (1876 aa)
Sros_6999Polyketide synthase modules and related protein- like protein; KEGG: mca:MCA1238 polyketide synthase. (1929 aa)
Sros_7120KEGG: spe:Spro_3049 pyridoxal-dependent decarboxylase. (466 aa)
Sros_7678KEGG: pca:Pcar_2442 L-lysine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (433 aa)
Sros_7731KEGG: avi:Avi_0155 hypothetical protein. (211 aa)
Sros_8009KEGG: sfu:Sfum_2670 cystathionine gamma-synthase. (406 aa)
Sros_8059KEGG: ade:Adeh_1978 acetolactate synthase, large subunit. (578 aa)
Sros_8110Cysteine desulfurase; KEGG: rru:Rru_A1068 aminotransferase, class V. (387 aa)
Sros_8139Phosphorylase; KEGG: geo:Geob_0532 alpha-glucan phosphorylase. (860 aa)
Sros_8249Polyketide synthase modules and related protein- like protein; KEGG: mca:MCA1238 polyketide synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (1501 aa)
Sros_9379Putative transcriptional regulator, GntR family; KEGG: mxa:MXAN_0212 aminotransferase, class I and II family protein. (441 aa)
Sros_9368KEGG: abo:ABO_0256 7,8-diaminononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (406 aa)
Sros_9291Aminotransferase; KEGG: csa:Csal_1034 aminotransferase. (426 aa)
Sros_9236KEGG: cvi:CV_0803 5-aminolevulinate synthase. (400 aa)
Sros_9197KEGG: avi:Avi_0155 hypothetical protein. (223 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (407 aa)
Sros_9103KEGG: msl:Msil_2816 thiamine pyrophosphate protein domain protein TPP-binding; Belongs to the TPP enzyme family. (577 aa)
Sros_9045Hypothetical protein. (163 aa)
Sros_8913KEGG: aca:ACP_3389 threonine synthase. (429 aa)
kblGlycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (390 aa)
Sros_8815Polyketide synthase modules and related protein- like protein; KEGG: xau:Xaut_1008 beta-ketoacyl synthase. (2111 aa)
Sros_8687Cysteine desulfurase; KEGG: afw:Anae109_1098 aminotransferase class V. (399 aa)
Sros_8563KEGG: afw:Anae109_3845 cystathionine gamma-lyase. (379 aa)
Sros_8547KEGG: gme:Gmet_3072 threonine dehydratase. (402 aa)
Sros_8434KEGG: ank:AnaeK_3893 aminotransferase class I and II. (359 aa)
Sros_8366KEGG: pol:Bpro_4782 Orn/DAP/Arg decarboxylase 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (392 aa)
Sros_8313KEGG: scl:sce8127 putative acetolactate synthase; Belongs to the TPP enzyme family. (550 aa)
Sros_8308KEGG: mxa:MXAN_1258 8-amino-7-oxononanoate synthase. (389 aa)
Sros_8284KEGG: sus:Acid_5307 alpha-ketoglutarate decarboxylase. (1241 aa)
patHistidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (353 aa)
Sros_0440Diaminopimelate decarboxylase-like protein; KEGG: bar:GBAA1438 diaminopimelate decarboxylase. (276 aa)
hemLKEGG: aeh:Mlg_0806 glutamate-1-semialdehyde 2,1- aminomutase. (437 aa)
serCPhosphoserine aminotransferase-like protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (369 aa)
Sros_1066KEGG: ppd:Ppro_2189 aminotransferase, class I and II. (401 aa)
Sros_1141Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (371 aa)
Sros_1177KEGG: scl:sce6892 hypothetical protein. (474 aa)
Sros_1198KEGG: cak:Caul_2891 acylneuraminate cytidylyltransferase. (244 aa)
Sros_1242KEGG: ade:Adeh_1832 methylmalonyl-CoA mutase. (135 aa)
Sros_1440KEGG: bph:Bphy_5923 pyridoxal-dependent decarboxylase. (474 aa)
Sros_1519KEGG: bcj:BCAS0137 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (460 aa)
Sros_1649L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
Sros_1703KEGG: scl:sce7549 isobutyryl-CoA mutase. (555 aa)
Sros_1947Aminotransferase; KEGG: sus:Acid_7662 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (433 aa)
Sros_1956KEGG: aba:Acid345_1534 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa)
Sros_2137Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1245 aa)
Sros_2186KEGG: mxa:MXAN_4525 non-ribosomal peptide synthase MxaA. (1436 aa)
Sros_2208Non-ribosomal peptide synthetase modules and related protein-like protein; KEGG: mxa:MXAN_3636 non-ribosomal peptide synthetase. (1829 aa)
Sros_2228KEGG: sme:SMc04326 putative aminotransferase protein. (379 aa)
Sros_2330KEGG: rle:RL4385 ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (403 aa)
Sros_2420Non-ribosomal peptide synthetase modules and related protein-like protein; KEGG: scl:sce8262 non-ribosomal peptide synthetase. (1839 aa)
Sros_2423KEGG: mxa:MXAN_2798 polyketide/non-ribosomal peptide synthetase. (1795 aa)
Sros_2429KEGG: bma:BMAA1021 thiotemplate mechanism natural product synthetase. (1160 aa)
Sros_2586KEGG: kpn:KPN_00421 GntR family transcriptional regulator. (478 aa)
Sros_2587Cystathionine gamma-synthase; KEGG: cko:CKO_04984 hypothetical protein. (390 aa)
Sros_2589KEGG: mlo:mlr3510 threonine dehydratase. (303 aa)
Sros_2669KEGG: gur:Gura_1493 aminotransferase, class V. (378 aa)
Sros_2875Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (234 aa)
hisCKEGG: bur:Bcep18194_C7445 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
Sros_3052KEGG: vei:Veis_4212 thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family. (584 aa)
Sros_3086Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: pca:Pcar_0266 glutamate-1-semialdehyde-2,1- aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (436 aa)
Sros_3143Aminotransferase; KEGG: bsu:BSU31440 aminotransferase. (381 aa)
Sros_3187KEGG: rru:Rru_A2480 methylmalonyl-CoA mutase. (633 aa)
Sros_3188KEGG: azc:AZC_1772 methylmalonyl-CoA mutase. (725 aa)
Sros_3334Non-ribosomal peptide synthetase modules and related protein-like protein; KEGG: mxa:MXAN_3636 non-ribosomal peptide synthetase. (1776 aa)
Sros_3418KEGG: dal:Dalk_0154 pyridoxal-dependent decarboxylase. (472 aa)
Sros_3468Non-ribosomal peptide synthetase modules and related protein-like protein; KEGG: mxa:MXAN_3779 non-ribosomal peptide synthetase/polyketide synthase. (7541 aa)
icmFMethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1073 aa)
Sros_3663KEGG: mxa:MXAN_3779 non-ribosomal peptide synthetase/polyketide synthase. (360 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (647 aa)
Sros_3753KEGG: hch:HCH_03695 diaminopimelate decarboxylase. (432 aa)
Sros_3766KEGG: dde:Dde_1609 amino acid adenylation. (2350 aa)
Sros_3767KEGG: pfl:PFL_3492 pyochelin synthetase F. (1835 aa)
Sros_3900Uncharacterized Fe-S protein-like protein; KEGG: scl:sce6725 sulfur-carrier protein. (247 aa)
Sros_3925KEGG: sil:SPO3529 serine hydroxymethyltransferase. (417 aa)
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene -1-carboxylic-acidsynthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (551 aa)
Sros_4068KEGG: pap:PSPA7_5597 hypothetical protein. (181 aa)
Sros_4119KEGG: aca:ACP_1470 threonine dehydratase catabolic. (319 aa)
Sros_4120Non-ribosomal peptide synthetase modules and related protein-like protein; KEGG: mxa:MXAN_3636 non-ribosomal peptide synthetase. (2720 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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