STRINGSTRING
ilvC ilvC Sros_9310 Sros_9310 Sros_0004 Sros_0004 Sros_0289 Sros_0289 hemA hemA Sros_0724 Sros_0724 Sros_0841 Sros_0841 Sros_0924 Sros_0924 Sros_1023 Sros_1023 Sros_1528 Sros_1528 Sros_1638 Sros_1638 dxr dxr dapB dapB Sros_3264 Sros_3264 zwf zwf Sros_3644 Sros_3644 Sros_3696 Sros_3696 Sros_3848 Sros_3848 Sros_3959 Sros_3959 Sros_4072 Sros_4072 Sros_4096 Sros_4096 Sros_4147 Sros_4147 Sros_4224 Sros_4224 Sros_4316 Sros_4316 Sros_4427 Sros_4427 Sros_4493 Sros_4493 Sros_4633 Sros_4633 Sros_4799 Sros_4799 Sros_4921 Sros_4921 Sros_4950 Sros_4950 Sros_5073 Sros_5073 Sros_5363 Sros_5363 Sros_5654 Sros_5654 Sros_5832 Sros_5832 Sros_5924 Sros_5924 zwf-2 zwf-2 Sros_6038 Sros_6038 Sros_6151 Sros_6151 Sros_6157 Sros_6157 Sros_6818 Sros_6818 Sros_6952 Sros_6952 Sros_6982 Sros_6982 Sros_7136 Sros_7136 Sros_7185 Sros_7185 proA proA Sros_7858 Sros_7858 Sros_9200 Sros_9200
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
Sros_9310KEGG: pca:Pcar_1903 aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (355 aa)
Sros_0004KEGG: dde:Dde_3470 6-phosphogluconate dehydrogenase- like protein. (313 aa)
Sros_0289KEGG: smd:Smed_2232 6-phosphogluconate dehydrogenase NAD-binding. (293 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (440 aa)
Sros_0724KEGG: scl:sce1370 dihydrofolate reductase family protein. (197 aa)
Sros_0841KEGG: scl:sce6636 hypothetical protein. (189 aa)
Sros_0924KEGG: baa:BA_2347 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (291 aa)
Sros_1023Bifunctional deaminase-reductase-like protein; KEGG: mes:Meso_2196 bifunctional deaminase- reductase-like. (178 aa)
Sros_1528KEGG: rce:RC1_2397 FAD-binding monooxygenase, putative. (496 aa)
Sros_1638KEGG: gme:Gmet_1629 homoserine dehydrogenase. (430 aa)
dxr1-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (394 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa)
Sros_3264KEGG: dac:Daci_3022 deaminase-reductase domain- containing protein. (180 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
Sros_3644KEGG: mlo:mlr0926 hypothetical protein. (190 aa)
Sros_3696KEGG: afw:Anae109_3251 deaminase-reductase domain- containing protein. (181 aa)
Sros_3848KEGG: scl:sce1370 dihydrofolate reductase family protein. (190 aa)
Sros_39596-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (476 aa)
Sros_4072KEGG: baa:BA_2347 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (287 aa)
Sros_4096KEGG: mxa:MXAN_1250 RibD domain protein. (192 aa)
Sros_4147KEGG: mxa:MXAN_4748 3-hydroxyisobutyrate dehydrogenase family protein. (294 aa)
Sros_4224KEGG: mlo:mlr2503 hypothetical protein. (178 aa)
Sros_4316KEGG: aba:Acid345_2541 glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
Sros_4427KEGG: baa:BA_2347 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (294 aa)
Sros_4493Bifunctional deaminase-reductase-like protein; KEGG: rfr:Rfer_2843 bifunctional deaminase- reductase-like. (214 aa)
Sros_4633KEGG: bha:BH1010 hypothetical protein; Belongs to the WrbA family. (226 aa)
Sros_4799Hypothetical protein; KEGG: kpn:KPN_02962 putative bifunctional deaminase- reductase. (89 aa)
Sros_4921Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (167 aa)
Sros_4950KEGG: baa:BA_2347 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (302 aa)
Sros_5073KEGG: baa:BA_2347 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (293 aa)
Sros_5363KEGG: baa:BA_2347 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (295 aa)
Sros_5654Hypothetical protein; KEGG: afw:Anae109_3251 deaminase-reductase domain- containing protein. (122 aa)
Sros_5832KEGG: sus:Acid_6255 deaminase-reductase domain- containing protein. (187 aa)
Sros_5924KEGG: reu:Reut_B4860 assimilatory nitrite reductase (NAD(P)H) large subunit precursor; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (814 aa)
zwf-2Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (545 aa)
Sros_6038KEGG: sus:Acid_7375 glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
Sros_61513-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase-like protein; KEGG: ppd:Ppro_2197 2-hydroxy-3-oxopropionate reductase. (402 aa)
Sros_6157KEGG: baa:BA_2347 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (288 aa)
Sros_6818KEGG: pla:Plav_0977 putative flavin-binding monooxygenase. (479 aa)
Sros_6952KEGG: abc:ACICU_01927 dihydrofolate reductase. (178 aa)
Sros_6982KEGG: afw:Anae109_3251 deaminase-reductase domain- containing protein. (183 aa)
Sros_7136KEGG: mno:Mnod_1061 6-phosphogluconate dehydrogenase NAD-binding. (321 aa)
Sros_7185KEGG: mxa:MXAN_1250 RibD domain protein. (190 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (429 aa)
Sros_7858Hypothetical protein; KEGG: ppg:PputGB1_3631 deaminase-reductase domain- containing protein. (199 aa)
Sros_9200KEGG: gsu:GSU0562 hypothetical protein. (183 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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