STRINGSTRING
Sros_0616 Sros_0616 Sros_0660 Sros_0660 Sros_0661 Sros_0661 Sros_1005 Sros_1005 sucC sucC sucD sucD Sros_1252 Sros_1252 Sros_1254 Sros_1254 mdh mdh Sros_2207 Sros_2207 Sros_2644 Sros_2644 Sros_2645 Sros_2645 Sros_6743 Sros_6743 Sros_6845 Sros_6845 Sros_7043 Sros_7043 Sros_8284 Sros_8284 Sros_8456 Sros_8456 Sros_8457 Sros_8457 Sros_8458 Sros_8458 Sros_8464 Sros_8464 Sros_8465 Sros_8465 Sros_8500 Sros_8500 fumC fumC pckG pckG Sros_8972 Sros_8972 Sros_8973 Sros_8973 Sros_8974 Sros_8974
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sros_0616KEGG: nwi:Nwi_1813 dihydrolipoamide dehydrogenase. (466 aa)
Sros_0660KEGG: eba:ebA3150 2-oxoglutarate ferredoxin oxidoreductase subunit beta. (348 aa)
Sros_0661KEGG: afw:Anae109_1891 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (617 aa)
Sros_1005KEGG: mlo:mll3842 citrate synthase 2; Belongs to the citrate synthase family. (368 aa)
sucCSuccinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
Sros_1252KEGG: aca:ACP_1789 citrate synthase 2; Belongs to the citrate synthase family. (373 aa)
Sros_1254KEGG: oca:OCAR_5440 isocitrate dehydrogenase, NADP- dependent; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
Sros_2207Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; KEGG: nmu:Nmul_A0856 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. (417 aa)
Sros_2644KEGG: sus:Acid_0914 dihydrolipoyllysine-residue succinyltransferase. (479 aa)
Sros_2645KEGG: mxa:MXAN_4219 alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase. (459 aa)
Sros_6743Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa)
Sros_6845KEGG: cko:CKO_03853 hypothetical protein. (396 aa)
Sros_7043Pyruvate dehydrogenase (acetyl-transferring); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
Sros_8284KEGG: sus:Acid_5307 alpha-ketoglutarate decarboxylase. (1241 aa)
Sros_8456KEGG: scl:sce6555 succinate dehydrogenase/fumarate reductase iron-sulfur subunit. (245 aa)
Sros_8457KEGG: sus:Acid_7402 succinate dehydrogenase flavoprotein subunit. (642 aa)
Sros_8458KEGG: aca:ACP_0103 succinate dehydrogenase, cytochrome b subunit. (253 aa)
Sros_8464KEGG: aba:Acid345_1384 succinate dehydrogenase flavoprotein subunit. (630 aa)
Sros_8465KEGG: aba:Acid345_1385 fumarate reductase iron- sulfur subunit. (253 aa)
Sros_8500Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (550 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
Sros_8972KEGG: bba:Bd0779 pyruvate dehydrogenase E2. (482 aa)
Sros_8973KEGG: ade:Adeh_1826 branched-chain alpha-keto acid dehydrogenase E1 component. (327 aa)
Sros_8974Pyruvate dehydrogenase (acetyl-transferring); KEGG: gme:Gmet_2509 dehydrogenase, E1 component. (363 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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