STRINGSTRING
Sros_0267 Sros_0267 pyrE pyrE Sros_0804 Sros_0804 Sros_0805 Sros_0805 dcd dcd Sros_0894 Sros_0894 Sros_1273 Sros_1273 Sros_1274 Sros_1274 Sros_1283 Sros_1283 Sros_1779 Sros_1779 pyrH pyrH pyrR pyrR pyrB pyrB pyrC pyrC carA carA carB carB Sros_2809 Sros_2809 pyrD pyrD pyrF pyrF pyrG pyrG cmk cmk Sros_3014 Sros_3014 Sros_3184 Sros_3184 Sros_4718 Sros_4718 Sros_4847 Sros_4847 thyA thyA Sros_6268 Sros_6268 Sros_6269 Sros_6269 psuG psuG Sros_6541 Sros_6541 Sros_6597 Sros_6597 Sros_6635 Sros_6635 dut dut Sros_7129 Sros_7129 ndk ndk Sros_7607 Sros_7607 pyrD-2 pyrD-2 tmk tmk upp upp
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Sros_02675'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase-like protein; KEGG: har:HEAR1476 putative 5'-nucleotidase family protein precursor. (463 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (178 aa)
Sros_0804Nucleotidase; KEGG: sse:Ssed_2354 nucleotidase. (201 aa)
Sros_0805Hypothetical protein; KEGG: bid:Bind_1545 thymidylate synthase. (238 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
Sros_0894KEGG: scl:sce7039 putative 5'-nucleotidase family protein; Belongs to the 5'-nucleotidase family. (602 aa)
Sros_1273Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (131 aa)
Sros_1274Thymidine phosphorylase; KEGG: ank:AnaeK_0651 pyrimidine-nucleoside phosphorylase. (426 aa)
Sros_1283Conserved hypothetical protein; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (267 aa)
Sros_1779KEGG: bbr:BB2432 allantoate amidohydrolase. (387 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (256 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (193 aa)
pyrBAspartate carbamoyltransferase; KEGG: scl:sce3822 hypothetical protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa)
carACarbamoyl-phosphate synthase (glutamine- hydrolyzing); KEGG: hch:HCH_01227 carbamoyl phosphate synthase small subunit; Belongs to the CarA family. (400 aa)
carBKEGG: geo:Geob_3271 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1097 aa)
Sros_2809KEGG: pca:Pcar_1295 2-polyprenylphenol hydroxylase/flavodoxin oxidoreductase. (291 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (324 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (237 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (563 aa)
cmkKEGG: sus:Acid_0051 cytidylate kinase. (218 aa)
Sros_3014Nitroreductase; KEGG: lch:Lcho_1290 nitroreductase. (195 aa)
Sros_3184KEGG: bcj:BCAM2779 cytosine deaminase. (393 aa)
Sros_4718KEGG: hypothetical protein. (203 aa)
Sros_4847KEGG: bmj:BMULJ_05301 N-isopropylammelide isopropylaminohydrolase. (376 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (265 aa)
Sros_6268Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (331 aa)
Sros_6269Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (731 aa)
psuGConserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (312 aa)
Sros_6541Barbiturase; Responsible for the hydrolysis of barbituric acid (2,4,6- trihydroxy-1,3-pyrimidine), an intermediate in the oxidative catabolism of pyrimidines. Catalyzes the hydrolytic opening of the pyrimidine ring of barbituric acid to yield ureidomalonic acid; Belongs to the cyclic amide hydrolase (CyAH) family. (363 aa)
Sros_6597KEGG: hne:HNE_3149 thymidine kinase. (210 aa)
Sros_6635Hydantoinase; KEGG: bav:BAV0626 hydantoinase. (470 aa)
dutdUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (147 aa)
Sros_7129Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (945 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa)
Sros_76072',3'-cyclic-nucleotide 2'-phosphodiesterase; KEGG: bar:GBAA4346 2',3'-cyclic nucleotide 2'- phosphodiesterase/3'-nucleotidase bifunctional periplasmic precursor protein; Belongs to the 5'-nucleotidase family. (585 aa)
pyrD-2Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (355 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (688 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa)
Your Current Organism:
Streptosporangium roseum
NCBI taxonomy Id: 479432
Other names: S. roseum DSM 43021, Streptosporangium roseum DSM 43021, Streptosporangium roseum str. DSM 43021, Streptosporangium roseum strain DSM 43021
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