STRINGSTRING
Sthe_0310 Sthe_0310 Sthe_0384 Sthe_0384 pfp pfp Sthe_0733 Sthe_0733 glmU glmU prs prs Sthe_0815 Sthe_0815 Sthe_0952 Sthe_0952 Sthe_1002 Sthe_1002 Sthe_1228 Sthe_1228 tpiA tpiA pgk pgk Sthe_1253 Sthe_1253 pfkA pfkA Sthe_1355 Sthe_1355 Sthe_1370 Sthe_1370 eno eno Sthe_1685 Sthe_1685 rpiA rpiA Sthe_1759 Sthe_1759 Sthe_1760 Sthe_1760 Sthe_1830 Sthe_1830 Sthe_1938 Sthe_1938 Sthe_1951 Sthe_1951 prs-2 prs-2 tal tal Sthe_2435 Sthe_2435 zwf zwf Sthe_2437 Sthe_2437 pgl pgl rbsK rbsK Sthe_2915 Sthe_2915 Sthe_3109 Sthe_3109 Sthe_3118 Sthe_3118 Sthe_3119 Sthe_3119 Sthe_3120 Sthe_3120 glpK glpK Sthe_3122 Sthe_3122 Sthe_3123 Sthe_3123 Sthe_3124 Sthe_3124 Sthe_3239 Sthe_3239 Sthe_3465 Sthe_3465
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Sthe_0310PFAM: ROK family protein; KEGG: mlo:mlr7234 glucose kinase. (325 aa)
Sthe_0384PFAM: Nucleotidyl transferase; KEGG: hau:Haur_4821 mannose-1-phosphate guanylyltransferase (GDP). (358 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (402 aa)
Sthe_0733PFAM: PfkB domain protein; KEGG: hypothetical protein; K00847 fructokinase. (328 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (464 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa)
Sthe_0815PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; SMART: CBS domain containing protein; KEGG: rrs:RoseRS_4395 hypothetical protein. (424 aa)
Sthe_0952TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; KEGG: sus:Acid_5289 2-keto-3-deoxy-phosphogluconate aldolase. (214 aa)
Sthe_1002TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: tfu:Tfu_0464 fructose 1,6-bisphosphatase II. (328 aa)
Sthe_1228PFAM: ROK family protein; KEGG: pth:PTH_2734 transcriptional regulator/sugar kinase. (335 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: mta:Moth_0263 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
Sthe_1253KEGG: csc:Csac_1953 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (374 aa)
Sthe_1355Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; KEGG: rxy:Rxyl_1134 phosphomannomutase. (447 aa)
Sthe_1370PFAM: NUDIX hydrolase; KEGG: aoe:Clos_1595 NUDIX hydrolase. (187 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
Sthe_1685KEGG: rrs:RoseRS_1777 ribulose-phosphate 3- epimerase; TIGRFAM: ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (234 aa)
Sthe_1759PFAM: Transketolase central region; Transketolase domain protein; KEGG: sus:Acid_2452 transketolase subunit B. (320 aa)
Sthe_1760PFAM: Transketolase domain protein; KEGG: dau:Daud_2078 transketolase domain-containing protein. (284 aa)
Sthe_1830PFAM: carbohydrate kinase FGGY; KEGG: rxy:Rxyl_1675 carbohydrate kinase, FGGY. (514 aa)
Sthe_1938KEGG: acr:Acry_0178 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (476 aa)
Sthe_1951Aldolase; KEGG: sat:SYN_00557 aldolase. (469 aa)
prs-2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. (942 aa)
Sthe_2435TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; NADP oxidoreductase coenzyme F420-dependent; 6- phosphogluconate dehydrogenase domain protein; KEGG: rxy:Rxyl_0050 6-phosphogluconate dehydrogenase-like protein. (301 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (514 aa)
Sthe_2437KEGG: cau:Caur_0502 glucose-6-P dehydrogenase subunit-like protein. (396 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (252 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (310 aa)
Sthe_2915PFAM: NUDIX hydrolase; KEGG: azo:azo1410 ADP-ribose diphosphatase. (195 aa)
Sthe_3109PFAM: FAD dependent oxidoreductase; KEGG: hha:Hhal_0079 FAD dependent oxidoreductase. (550 aa)
Sthe_3118Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (563 aa)
Sthe_3119Phosphotransferase system, phosphocarrier protein HPr; TIGRFAM: phosphocarrier, HPr family; PFAM: phosphoryl transfer system HPr; KEGG: pin:Ping_2439 phosphotransferase system, phosphocarrier protein HPr. (91 aa)
Sthe_3120TIGRFAM: dihydroxyacetone kinase, phosphotransfer subunit; PFAM: PTS system fructose subfamily IIA component; KEGG: bra:BRADO4613 putative dihydroxyacetone kinase phosphotransfer protein (DhaH/M-like). (133 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (498 aa)
Sthe_3122TIGRFAM: dihydroxyacetone kinase, L subunit; PFAM: Dak phosphatase; KEGG: dvm:DvMF_2583 dihydroxyacetone kinase, L subunit. (213 aa)
Sthe_3123Dihydroxyacetone kinase, DhaK subunit; KEGG: scl:sce2491 Glycerone kinase DAK1 domain- containing protein; TIGRFAM: dihydroxyacetone kinase, DhaK subunit; PFAM: Dak kinase. (333 aa)
Sthe_3124TIGRFAM: MIP family channel protein; PFAM: major intrinsic protein; KEGG: hypothetical protein; K09876 aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family. (319 aa)
Sthe_3239PFAM: PfkB domain protein; KEGG: xcv:XCV0122 2-keto-3-deoxygluconate kinase. (322 aa)
Sthe_3465PFAM: mannose-6-phosphate isomerase type I; KEGG: esa:ESA_01679 hypothetical protein. (369 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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