STRINGSTRING
Sthe_0027 Sthe_0027 Sthe_0031 Sthe_0031 Sthe_0072 Sthe_0072 Sthe_0180 Sthe_0180 Sthe_0181 Sthe_0181 Sthe_0182 Sthe_0182 Sthe_0368 Sthe_0368 Sthe_0369 Sthe_0369 Sthe_0405 Sthe_0405 Sthe_0485 Sthe_0485 Sthe_0595 Sthe_0595 Sthe_0597 Sthe_0597 Sthe_0598 Sthe_0598 Sthe_0648 Sthe_0648 Sthe_0710 Sthe_0710 Sthe_0750 Sthe_0750 Sthe_0751 Sthe_0751 Sthe_0890 Sthe_0890 Sthe_0910 Sthe_0910 Sthe_0911 Sthe_0911 Sthe_0966 Sthe_0966 Sthe_0992 Sthe_0992 Sthe_1232 Sthe_1232 Sthe_1269 Sthe_1269 Sthe_1437 Sthe_1437 Sthe_1603 Sthe_1603 Sthe_1862 Sthe_1862 Sthe_1940 Sthe_1940 Sthe_1941 Sthe_1941 Sthe_2026 Sthe_2026 Sthe_2027 Sthe_2027 Sthe_2031 Sthe_2031 Sthe_2039 Sthe_2039 Sthe_2197 Sthe_2197 Sthe_2198 Sthe_2198 Sthe_2247 Sthe_2247 Sthe_2252 Sthe_2252 Sthe_2401 Sthe_2401 Sthe_2411 Sthe_2411 Sthe_2441 Sthe_2441 Sthe_2457 Sthe_2457 Sthe_2526 Sthe_2526 Sthe_2665 Sthe_2665 Sthe_2666 Sthe_2666 Sthe_2675 Sthe_2675 Sthe_2694 Sthe_2694 Sthe_2695 Sthe_2695 Sthe_2789 Sthe_2789 Sthe_2857 Sthe_2857 Sthe_3049 Sthe_3049 Sthe_3075 Sthe_3075 Sthe_3127 Sthe_3127 Sthe_3170 Sthe_3170 Sthe_3273 Sthe_3273 Sthe_3274 Sthe_3274 Sthe_3284 Sthe_3284 Sthe_3316 Sthe_3316 Sthe_3327 Sthe_3327 Sthe_3401 Sthe_3401 Sthe_3406 Sthe_3406
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sthe_0027Diguanylate cyclase with PAS/PAC sensor; KEGG: sgr:SGR_2001 putative integral membrane phosphodiesterase; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: GGDEF domain containing protein; PAS domain containing protein. (610 aa)
Sthe_0031PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: mma:MM_1068 two-component response regulator. (133 aa)
Sthe_0072Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; Tetratricopeptide domain protein; KEGG: sus:Acid_5780 serine/threonine protein kinase. (992 aa)
Sthe_0180Hypothetical protein; KEGG: rrs:RoseRS_0444 transposase, IS4 family protein. (128 aa)
Sthe_0181Histidine kinase; KEGG: bcl:ABC0528 two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein. (477 aa)
Sthe_0182Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: bcl:ABC0529 two-component response regulator. (231 aa)
Sthe_0368KEGG: det:DET0136 sensory box sensor histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; histidine kinase HAMP region domain protein. (598 aa)
Sthe_0369Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: lac:LBA0078 putative response regulator. (233 aa)
Sthe_0405Diguanylate cyclase and metal dependent phosphohydrolase; KEGG: dau:Daud_0771 diguanylate cyclase with PAS/PAC sensor; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; metal- dependent phosphohydrolase HD sub domain; GAF domain protein; Metal-dependent hydrolase HDOD; SMART: GGDEF domain containing protein; metal- dependent phosphohydrolase HD region; GAF domain protein. (888 aa)
Sthe_0485Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; TPR repeat- containing protein; SMART: helix-turn-helix domain protein; Tetratricopeptide domain protein; KEGG: scl:sce5225 protein kinase. (810 aa)
Sthe_0595Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; regulatory protein MerR; SMART: regulatory protein LuxR; KEGG: sma:SAV_2729 LuxR family transcriptional regulator. (1034 aa)
Sthe_0597Histidine kinase; PFAM: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SMART: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; KEGG: gvi:gll1661 similar to two-component sensor histidine kinase. (489 aa)
Sthe_0598Adenylate/guanylate cyclase with TPR repeats; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; Tetratricopeptide TPR_4; SMART: adenylyl cyclase class-3/4/guanylyl cyclase; Tetratricopeptide domain protein; KEGG: hau:Haur_1430 adenylate/guanylate cyclase. (1151 aa)
Sthe_0648PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: afw:Anae109_1850 response regulator receiver protein. (131 aa)
Sthe_0710Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); KEGG: ana:all0219 hypothetical protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; PAS fold-3 domain protein; GGDEF domain containing protein; PAS fold domain protein; PAS fold-4 domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAS domain containing protein. (942 aa)
Sthe_0750Histidine kinase; KEGG: rrs:RoseRS_0613 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (464 aa)
Sthe_0751Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: mta:Moth_1478 two component transcriptional regulator. (224 aa)
Sthe_0890PFAM: glycosyl transferase family 2; KEGG: rrs:RoseRS_1291 glycosyl transferase family protein. (342 aa)
Sthe_0910Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: sru:SRU_2488 response regulator DrrA. (240 aa)
Sthe_0911Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: hau:Haur_0906 integral membrane sensor signal transduction histidine kinase. (543 aa)
Sthe_0966KEGG: nth:Nther_2059 metal dependent phosphohydrolase; TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. (432 aa)
Sthe_0992PFAM: GAF domain protein; histidine kinase dimerisation/phosphoacceptor; ATP-binding region ATPase domain protein; SMART: GAF domain protein; ATP-binding region ATPase domain protein; KEGG: rca:Rcas_4451 signal transduction histidine kinase. (652 aa)
Sthe_1232PFAM: Tetratricopeptide TPR_2 repeat protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; KEGG: mag:amb4019 methyltransferase. (643 aa)
Sthe_1269Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: afw:Anae109_0881 integral membrane sensor signal transduction histidine kinase. (567 aa)
Sthe_1437Two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; response regulator receiver; SMART: response regulator receiver; KEGG: saq:Sare_0404 two component transcriptional regulator. (254 aa)
Sthe_1603PFAM: response regulator receiver; ANTAR domain protein; SMART: response regulator receiver; KEGG: dth:DICTH_0982 two-component system, regulatory protein. (200 aa)
Sthe_1862PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: afw:Anae109_2598 response regulator receiver protein. (135 aa)
Sthe_1940Histidine kinase; KEGG: pth:PTH_0047 signal transduction protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (366 aa)
Sthe_1941Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: pth:PTH_0048 response regulator. (240 aa)
Sthe_2026Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: mta:Moth_1130 periplasmic sensor signal transduction histidine kinase. (493 aa)
Sthe_2027Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: sth:STH415 two-component response regulator. (244 aa)
Sthe_2031Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: afw:Anae109_1498 GAF sensor signal transduction histidine kinase. (383 aa)
Sthe_2039Multi-sensor signal transduction histidine kinase; KEGG: cau:Caur_1171 PAS sensor protein; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; PAS fold-4 domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein. (523 aa)
Sthe_2197Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: hau:Haur_0905 two component transcriptional regulator. (236 aa)
Sthe_2198Histidine kinase; KEGG: hau:Haur_0906 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein. (538 aa)
Sthe_2247Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; SMART: regulatory protein LuxR; KEGG: pol:Bpro_3193 transcriptional regulator, LuxR family. (875 aa)
Sthe_2252PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: afw:Anae109_2598 response regulator receiver protein. (124 aa)
Sthe_2401Multi-sensor signal transduction histidine kinase; KEGG: ana:all5210 two-component hybrid sensor and regulator; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; GAF domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; PAS domain containing protein. (1448 aa)
Sthe_2411Multi-sensor signal transduction histidine kinase; KEGG: scl:sce0428 histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAC repeat-containing protein; GAF domain protein; PAS domain containing protein. (788 aa)
Sthe_2441PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: mxa:MXAN_2962 response regulator. (127 aa)
Sthe_2457PFAM: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: acr:Acry_0713 osmosensitive K+ channel signal transduction histidine kinase. (424 aa)
Sthe_2526Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; SMART: regulatory protein LuxR; KEGG: scl:sce5225 protein kinase. (799 aa)
Sthe_2665Multi-sensor signal transduction histidine kinase; KEGG: scl:sce0186 two-component histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; PAC repeat-containing protein. (645 aa)
Sthe_2666Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: afw:Anae109_3104 two component transcriptional regulator. (233 aa)
Sthe_2675PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: lhk:LHK_00225 BaeR. (132 aa)
Sthe_2694Multi-sensor signal transduction histidine kinase; KEGG: scl:sce5443 protein kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; PAS fold domain protein; GAF domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; PAS domain containing protein. (668 aa)
Sthe_2695Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); KEGG: gsu:GSU2016 sensory box/GGDEF family protein; TIGRFAM: diguanylate cyclase; PAS sensor protein; PFAM: EAL domain protein; PAS fold-3 domain protein; GGDEF domain containing protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: EAL domain protein; GGDEF domain containing protein; PAC repeat-containing protein; PAS domain containing protein. (760 aa)
Sthe_2789KEGG: tbd:Tbd_2634 diguanylate cyclase with PAS/PAC sensor; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein; PAS fold-4 domain protein; SMART: GGDEF domain containing protein; GAF domain protein; PAS domain containing protein. (747 aa)
Sthe_2857PFAM: glycosyl transferase family 2; KEGG: gur:Gura_3553 glycosyl transferase family protein. (540 aa)
Sthe_3049PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: ade:Adeh_3844 response regulator receiver domain-containing protein. (125 aa)
Sthe_3075Multi-sensor signal transduction histidine kinase; KEGG: mxa:MXAN_7398 sensor histidine kinase; TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; histidine kinase A domain protein; PAS domain containing protein. (936 aa)
Sthe_3127Two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; response regulator receiver; SMART: response regulator receiver; KEGG: hch:HCH_00579 response regulator. (256 aa)
Sthe_3170KEGG: scl:sce6351 protein kinase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; tyrosine protein kinase; Serine/threonine protein kinase-related; GAF domain protein; SMART: GGDEF domain containing protein; serine/threonine protein kinase; tyrosine protein kinase; GAF domain protein. (1765 aa)
Sthe_3273Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: smd:Smed_5362 two component transcriptional regulator. (232 aa)
Sthe_3274Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: glo:Glov_0589 multi-sensor signal transduction histidine kinase. (398 aa)
Sthe_3284Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: har:HEAR1907 osmolarity response regulator. (310 aa)
Sthe_3316KEGG: scl:sce5225 protein kinase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; TPR repeat- containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: GGDEF domain containing protein; Tetratricopeptide repeat. (907 aa)
Sthe_3327KEGG: scl:sce5225 protein kinase; TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; TPR repeat- containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: GGDEF domain containing protein; Tetratricopeptide repeat. (1156 aa)
Sthe_3401Transcriptional regulator, Crp/Fnr family; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; KEGG: smd:Smed_6276 CRP/FNR family transcriptional regulator. (252 aa)
Sthe_3406KEGG: gur:Gura_1941 metal dependent phosphohydrolase; TIGRFAM: diguanylate cyclase; metal dependent phophohydrolase; PFAM: GGDEF domain containing protein; GAF domain protein; metal-dependent phosphohydrolase HD sub domain; Metal-dependent hydrolase HDOD; SMART: GGDEF domain containing protein; metal- dependent phosphohydrolase HD region; GAF domain protein. (1113 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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