node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Sthe_0734 | Sthe_2363 | Sthe_0734 | Sthe_2363 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.906 |
Sthe_0734 | gmk | Sthe_0734 | Sthe_0381 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.941 |
Sthe_0734 | ndk | Sthe_0734 | Sthe_2335 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.921 |
Sthe_2104 | Sthe_2363 | Sthe_2104 | Sthe_2363 | Glutaredoxin; Contains selenocysteine; PFAM: glutaredoxin; KEGG: fma:FMG_0548 glutaredoxin. | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.997 |
Sthe_2363 | Sthe_0734 | Sthe_2363 | Sthe_0734 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.906 |
Sthe_2363 | Sthe_2104 | Sthe_2363 | Sthe_2104 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Glutaredoxin; Contains selenocysteine; PFAM: glutaredoxin; KEGG: fma:FMG_0548 glutaredoxin. | 0.997 |
Sthe_2363 | gmk | Sthe_2363 | Sthe_0381 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.916 |
Sthe_2363 | ndk | Sthe_2363 | Sthe_2335 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.918 |
Sthe_2363 | tmk | Sthe_2363 | Sthe_0948 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.948 |
Sthe_2721 | Sthe_3458 | Sthe_2721 | Sthe_3458 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: dCMP deaminase; Dcd1p; K01493 dCMP deaminase. | PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. | 0.911 |
Sthe_2721 | tmk | Sthe_2721 | Sthe_0948 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: dCMP deaminase; Dcd1p; K01493 dCMP deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.931 |
Sthe_3238 | Sthe_3458 | Sthe_3238 | Sthe_3458 | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. | PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. | 0.944 |
Sthe_3238 | dcd | Sthe_3238 | Sthe_2300 | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.924 |
Sthe_3238 | ndk | Sthe_3238 | Sthe_2335 | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.918 |
Sthe_3238 | pyrG | Sthe_3238 | Sthe_1429 | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.917 |
Sthe_3458 | Sthe_2721 | Sthe_3458 | Sthe_2721 | PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: dCMP deaminase; Dcd1p; K01493 dCMP deaminase. | 0.911 |
Sthe_3458 | Sthe_3238 | Sthe_3458 | Sthe_3238 | PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. | TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. | 0.944 |
Sthe_3458 | dcd | Sthe_3458 | Sthe_2300 | PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.932 |
Sthe_3458 | ndk | Sthe_3458 | Sthe_2335 | PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.918 |
Sthe_3458 | tmk | Sthe_3458 | Sthe_0948 | PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.918 |