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gmk gmk Sthe_0734 Sthe_0734 tmk tmk pyrG pyrG Sthe_2104 Sthe_2104 dcd dcd ndk ndk Sthe_2363 Sthe_2363 Sthe_2721 Sthe_2721 Sthe_3238 Sthe_3238 Sthe_3458 Sthe_3458
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (217 aa)
Sthe_0734(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (748 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (553 aa)
Sthe_2104Glutaredoxin; Contains selenocysteine; PFAM: glutaredoxin; KEGG: fma:FMG_0548 glutaredoxin. (78 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (197 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (150 aa)
Sthe_2363Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1139 aa)
Sthe_2721PFAM: CMP/dCMP deaminase zinc-binding; KEGG: dCMP deaminase; Dcd1p; K01493 dCMP deaminase. (191 aa)
Sthe_3238TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. (171 aa)
Sthe_3458PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. (179 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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