STRINGSTRING
Sthe_0231 Sthe_0231 Sthe_0232 Sthe_0232 Sthe_0234 Sthe_0234 Sthe_0258 Sthe_0258 Sthe_0259 Sthe_0259 Sthe_0474 Sthe_0474 moaA moaA Sthe_0740 Sthe_0740 Sthe_0748 Sthe_0748 Sthe_0801 Sthe_0801 thiL thiL mobA mobA Sthe_1113 Sthe_1113 Sthe_1397 Sthe_1397 Sthe_1398 Sthe_1398 Sthe_1399 Sthe_1399 Sthe_1400 Sthe_1400 Sthe_1401 Sthe_1401 Sthe_1402 Sthe_1402 Sthe_1403 Sthe_1403 Sthe_1404 Sthe_1404 Sthe_1405 Sthe_1405 Sthe_1406 Sthe_1406 Sthe_1407 Sthe_1407 Sthe_1408 Sthe_1408 Sthe_1492 Sthe_1492 thiE thiE thiE-2 thiE-2 thiG thiG Sthe_1496 Sthe_1496 Sthe_1569 Sthe_1569 Sthe_2181 Sthe_2181 Sthe_2182 Sthe_2182 Sthe_2308 Sthe_2308 Sthe_2309 Sthe_2309 Sthe_2310 Sthe_2310 Sthe_2405 Sthe_2405 Sthe_2406 Sthe_2406 moaC moaC Sthe_2775 Sthe_2775 Sthe_2776 Sthe_2776 Sthe_2777 Sthe_2777 Sthe_2778 Sthe_2778 Sthe_2811 Sthe_2811 Sthe_2812 Sthe_2812 Sthe_2813 Sthe_2813 Sthe_2959 Sthe_2959 Sthe_3084 Sthe_3084 Sthe_3085 Sthe_3085 Sthe_3086 Sthe_3086 Sthe_3096 Sthe_3096 Sthe_3097 Sthe_3097 rsgA rsgA Sthe_3181 Sthe_3181 Sthe_3386 Sthe_3386 Sthe_3387 Sthe_3387 Sthe_3391 Sthe_3391 Sthe_3392 Sthe_3392 Sthe_3393 Sthe_3393 Sthe_3394 Sthe_3394 Sthe_3395 Sthe_3395 Sthe_3396 Sthe_3396 Sthe_3397 Sthe_3397 Sthe_3424 Sthe_3424
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Sthe_0231PFAM: [2Fe-2S]-binding domain protein; ferredoxin; KEGG: rxy:Rxyl_1873 (2Fe-2S)-binding protein. (169 aa)
Sthe_0232PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: rxy:Rxyl_0113 molybdopterin dehydrogenase, FAD-binding protein. (288 aa)
Sthe_0234PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: ape:APE_2216.1 aldehyde dehydrogenase, large subunit. (797 aa)
Sthe_0258PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: cau:Caur_2105 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding. (755 aa)
Sthe_0259Carbon-monoxide dehydrogenase (acceptor); PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: cau:Caur_2105 aldehyde oxidase and xanthine dehydrogenase molybdopterin binding. (772 aa)
Sthe_0474Molybdenum cofactor synthesis domain protein; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (167 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (349 aa)
Sthe_0740Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (412 aa)
Sthe_0748TIGRFAM: MoaD family protein; PFAM: molybdopterin biosynthesis MoaE protein; thiamineS protein; KEGG: rca:Rcas_2923 molybdopterin converting factor, subunit 1. (232 aa)
Sthe_0801PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: hmo:HM1_2048 molybdopterin biosynthesis protein MoeB, putative. (345 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis MobB region containing protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (224 aa)
Sthe_1113Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (413 aa)
Sthe_1397PFAM: carbon monoxide dehydrogenase subunit G; KEGG: cau:Caur_3470 carbon monoxide dehydrogenase subunit G. (147 aa)
Sthe_1398PFAM: [2Fe-2S]-binding domain protein; ferredoxin; KEGG: cau:Caur_3469 2Fe-2S iron-sulfur cluster binding domain-containing protein. (164 aa)
Sthe_1399PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: ape:APE_2216.1 aldehyde dehydrogenase, large subunit. (785 aa)
Sthe_1400PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: cau:Caur_3467 molybdopterin dehydrogenase FAD- binding. (287 aa)
Sthe_1401PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: cau:Caur_0984 ATPase. (321 aa)
Sthe_1402PFAM: VWA containing CoxE family protein; SMART: von Willebrand factor type A; KEGG: rca:Rcas_1453 VWA containing CoxE family protein. (421 aa)
Sthe_1403PFAM: protein of unknown function DUF182; KEGG: rrs:RoseRS_0502 hypothetical protein. (103 aa)
Sthe_1404Cyclic nucleotide-binding protein; PFAM: protein of unknown function DUF182; KEGG: rrs:RoseRS_0501 xanthine and Co dehydrogenase maturation factor. (267 aa)
Sthe_1405KEGG: rrs:RoseRS_0825 MobA-like protein-like protein. (204 aa)
Sthe_1406PFAM: NUDIX hydrolase; KEGG: sth:STH2026 hypothetical protein. (179 aa)
Sthe_1407Carbon-monoxide dehydrogenase (acceptor); PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: rxy:Rxyl_0112 xanthine dehydrogenase, molybdenum binding subunit apoprotein. (772 aa)
Sthe_1408Hypothetical protein. (346 aa)
Sthe_1492TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: zmo:ZMO0738 bifunctional sulfur carrier protein/thiazole synthase protein. (67 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (212 aa)
thiE-2Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (225 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)
Sthe_1496TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: cau:Caur_0373 phosphomethylpyrimidine kinase. (279 aa)
Sthe_1569PFAM: thiamineS protein; KEGG: rca:Rcas_2923 molybdopterin converting factor, subunit 1. (85 aa)
Sthe_2181PFAM: oxidoreductase molybdopterin binding; Mo-co oxidoreductase dimerisation domain; KEGG: sen:SACE_3346 oxidoreductase, molybdopterin binding. (505 aa)
Sthe_2182Hypothetical protein. (85 aa)
Sthe_2308PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: gka:GKP19 nicotine dehydrogenase chain A. (290 aa)
Sthe_2309PFAM: [2Fe-2S]-binding domain protein; ferredoxin; KEGG: rca:Rcas_0843 2Fe-2S iron-sulfur cluster binding domain-containing protein. (173 aa)
Sthe_2310PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: gka:GKP21 molybdopterin binding oxidoreductase large subunit. (809 aa)
Sthe_2405KEGG: bcs:BCAN_A0953 hypothetical protein. (212 aa)
Sthe_2406PFAM: molybdopterin binding domain; KEGG: mta:Moth_0932 molybdopterin binding domain- containing protein. (356 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (159 aa)
Sthe_2775PFAM: protein of unknown function DUF182; YHS domain protein; SMART: TRASH domain protein; KEGG: bxe:Bxe_C0035 sulfurylase large subunit, molybdopterin cytosine dinucleotide biosynthesis / sulfurylase small subunit, molybdopterin cytosine dinucleotide biosynthesis. (346 aa)
Sthe_2776TIGRFAM: carbon-monoxide dehydrogenase, large subunit; PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: aeh:Mlg_1564 carbon monoxide dehydrogenase, large subunit apoprotein. (784 aa)
Sthe_2777PFAM: [2Fe-2S]-binding domain protein; ferredoxin; KEGG: aeh:Mlg_1563 carbon monoxide dehydrogenase, small subunit. (178 aa)
Sthe_2778PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: bxe:Bxe_A2144 carbon monoxide dehydrogenase, medium subunit. (292 aa)
Sthe_2811PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: rhi:NGR_c05940 putative dehydrogenase. (785 aa)
Sthe_2812PFAM: [2Fe-2S]-binding domain protein; ferredoxin; KEGG: reh:H16_B0745 4-hydroxybenzoyl-CoA reductase, 2Fe-2S iron-sulfur cluster subunit C. (155 aa)
Sthe_2813PFAM: molybdopterin dehydrogenase FAD-binding; CO dehydrogenase flavoprotein domain protein; KEGG: rhi:NGR_c05970 carbon monoxide dehydrogenase medium chain. (292 aa)
Sthe_2959Hypothetical protein. (98 aa)
Sthe_3084Molybdate ABC transporter, inner membrane subunit; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (283 aa)
Sthe_3085TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: scl:sce1135 ABC-type molybdate transporter, substrate-binding protein. (313 aa)
Sthe_3086Transcriptional regulator of molybdate metabolism, XRE family; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: sfu:Sfum_3707 transcriptional regulator of molybdate metabolism, XRE family. (378 aa)
Sthe_3096Hypothetical protein. (53 aa)
Sthe_3097Hypothetical protein. (156 aa)
rsgARibosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (317 aa)
Sthe_3181PFAM: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding; aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; KEGG: mlo:mll2287 4-hydroxybenzoyl-CoA reductase subunit alpha. (753 aa)
Sthe_3386KEGG: gsu:GSU0910 aldehyde:ferredoxin oxidoreductase, tungsten-containing; PFAM: aldehyde ferredoxin oxidoreductase; Aldehyde ferredoxin oxidoreductase; SMART: Aldehyde ferredoxin oxidoreductase. (596 aa)
Sthe_3387PFAM: thiamineS protein. (93 aa)
Sthe_3391Hypothetical protein. (74 aa)
Sthe_3392Formate dehydrogenase accessory protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (287 aa)
Sthe_3393Hypothetical protein. (120 aa)
Sthe_3394PFAM: regulatory protein LysR; KEGG: sfu:Sfum_1701 putative transcriptional regulator, ModE family. (136 aa)
Sthe_3395ABC-type tungstate transport system permease component-like protein; KEGG: geo:Geob_0274 extracellular solute-binding protein. (321 aa)
Sthe_3396PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sfu:Sfum_0028 binding-protein-dependent transport systems inner membrane component. (234 aa)
Sthe_3397PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: dal:Dalk_1502 ABC transporter related; Belongs to the ABC transporter superfamily. (240 aa)
Sthe_3424Transcriptional activator, TenA family; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (226 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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