STRINGSTRING
Sthe_0142 Sthe_0142 Sthe_0143 Sthe_0143 Sthe_0144 Sthe_0144 Sthe_0145 Sthe_0145 Sthe_0146 Sthe_0146 Sthe_0147 Sthe_0147 Sthe_0204 Sthe_0204 Sthe_0291 Sthe_0291 murG murG Sthe_0545 Sthe_0545 Sthe_1022 Sthe_1022 Sthe_1162 Sthe_1162 Sthe_1163 Sthe_1163 murA murA murB murB Sthe_1650 Sthe_1650 Sthe_1985 Sthe_1985 nrdR nrdR ftsZ ftsZ Sthe_1988 Sthe_1988 Sthe_1989 Sthe_1989 ddl ddl murC murC Sthe_1992 Sthe_1992 murD murD mraY mraY murF murF Sthe_1996 Sthe_1996 Sthe_1997 Sthe_1997 rsmH rsmH mraZ mraZ minE minE Sthe_2011 Sthe_2011 minC minC Sthe_2013 Sthe_2013 Sthe_2014 Sthe_2014 Sthe_2132 Sthe_2132 Sthe_2212 Sthe_2212 Sthe_2220 Sthe_2220 Sthe_2367 Sthe_2367 Sthe_3258 Sthe_3258 mltG mltG Sthe_3350 Sthe_3350 Sthe_3351 Sthe_3351 Sthe_3506 Sthe_3506
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Sthe_0142PFAM: Peptidase M23; Peptidoglycan-binding LysM; SMART: Peptidoglycan-binding LysM; KEGG: sth:STH2132 hypothetical protein. (300 aa)
Sthe_0143TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl; KEGG: rrs:RoseRS_1283 cell shape determining protein MreB. (353 aa)
Sthe_0144Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (272 aa)
Sthe_0145PFAM: domain of unknown function DUF1727; Mur ligase middle domain protein; KEGG: rrs:RoseRS_0500 hypothetical protein. (461 aa)
Sthe_0146PFAM: CobB/CobQ domain protein glutamine amidotransferase; KEGG: rca:Rcas_1484 glutamine amidotransferase. (242 aa)
Sthe_0147PFAM: metallophosphoesterase; KEGG: sth:STH891 hypothetical protein. (249 aa)
Sthe_0204PFAM: Peptidase M23; Peptidoglycan-binding LysM; SMART: Peptidoglycan-binding LysM; KEGG: tth:TTC0351 cell wall endopeptidase. (363 aa)
Sthe_0291PFAM: glycosyl transferase family 51; penicillin- binding protein transpeptidase; KEGG: hau:Haur_3225 1A family penicillin-binding protein. (811 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (384 aa)
Sthe_0545PFAM: Peptidase M23; Lytic transglycosylase catalytic; KEGG: pth:PTH_0856 hypothetical protein. (328 aa)
Sthe_1022KEGG: cau:Caur_1851 helix-turn-helix domain- containing protein. (274 aa)
Sthe_1162PFAM: cell cycle protein; KEGG: rca:Rcas_0578 cell cycle protein; Belongs to the SEDS family. (436 aa)
Sthe_1163Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; KEGG: cau:Caur_1804 peptidoglycan glycosyltransferase. (553 aa)
murAUDP-N-acetylglucosamine1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (424 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (321 aa)
Sthe_1650PFAM: Peptidase M23; KEGG: tte:TTE0841 membrane proteins related to metalloendopeptidase. (407 aa)
Sthe_1985Hypothetical protein. (407 aa)
nrdRATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (158 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (369 aa)
Sthe_1988KEGG: sth:STH1218 cell division protein FtsA. (391 aa)
Sthe_1989Polypeptide-transport-associated domain protein FtsQ-type; Essential cell division protein. (256 aa)
ddlD-alanine/D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (375 aa)
murCUDP-N-acetylmuramate/alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (473 aa)
Sthe_1992TIGRFAM: cell division protein FtsW; PFAM: cell cycle protein; KEGG: hau:Haur_3512 cell division protein FtsW; Belongs to the SEDS family. (464 aa)
murDUDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (481 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (346 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanylligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (463 aa)
Sthe_1996Peptidoglycan glycosyltransferase; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: cau:Caur_0761 peptidoglycan glycosyltransferase. (582 aa)
Sthe_1997KEGG: hau:Haur_3518 hypothetical protein. (160 aa)
rsmHS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (326 aa)
mraZTIGRFAM: MraZ protein; PFAM: protein of unknown function UPF0040; KEGG: rca:Rcas_1104 MraZ protein; Belongs to the MraZ family. (142 aa)
minECell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (95 aa)
Sthe_2011TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid ac-diamide synthase; KEGG: pth:PTH_0822 septum formation inhibitor- activating ATPase. (287 aa)
minCSeptum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (238 aa)
Sthe_2013Penicillin-binding protein 2; KEGG: cau:Caur_0113 peptidoglycan glycosyltransferase; TIGRFAM: penicillin-binding protein 2; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain. (754 aa)
Sthe_2014TIGRFAM: rod shape-determining protein MreD; KEGG: hmo:HM1_2728 rod shape-determining protein, putative. (211 aa)
Sthe_2132PFAM: Peptidase M23; Lytic transglycosylase catalytic; KEGG: bpd:BURPS668_A0166 rhs element Vgr protein. (719 aa)
Sthe_2212Penicillin-binding protein 2; KEGG: sfu:Sfum_2589 peptidoglycan glycosyltransferase; TIGRFAM: penicillin-binding protein 2; PFAM: penicillin-binding protein transpeptidase; NTF2 domain protein transpeptidase; Penicillin-binding protein dimerisation domain. (709 aa)
Sthe_2220PFAM: cell cycle protein; KEGG: rrs:RoseRS_2349 cell cycle protein; Belongs to the SEDS family. (380 aa)
Sthe_2367TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl; cell division protein FtsA; KEGG: cau:Caur_3039 cell shape determining protein MreB. (334 aa)
Sthe_3258PFAM: glycosyl transferase family 51; penicillin- binding protein transpeptidase; KEGG: sat:SYN_00304 multimodular transpeptidase- transglycosylase. (795 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (348 aa)
Sthe_3350PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: cja:CJA_0793 D-alanyl-D-alanine carboxypeptidase family; Belongs to the peptidase S11 family. (338 aa)
Sthe_3351PFAM: Peptidase M23; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding LysM; KEGG: bpt:Bpet2547 M23-family peptidase. (544 aa)
Sthe_3506PFAM: Lytic transglycosylase catalytic; Peptidoglycan-binding lysin domain; SMART: Peptidoglycan-binding LysM; KEGG: cvi:CV_2611 peptidoglycan N- acetylmuramoylhydrolase. (299 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.