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atpD atpD atpC atpC Sthe_1390 Sthe_1390 purD purD guaA guaA purN purN pfkA pfkA Sthe_1339 Sthe_1339 folD folD Sthe_1297 Sthe_1297 Sthe_1293 Sthe_1293 purC purC purS purS purQ purQ purL purL purF purF Sthe_1261 Sthe_1261 pgk pgk tpiA tpiA Sthe_1220 Sthe_1220 nnrE nnrE Sthe_1127 Sthe_1127 accA accA adk adk Sthe_1027 Sthe_1027 Sthe_0970 Sthe_0970 nadK nadK tmk tmk pyrE pyrE carB carB carA carA pyrC pyrC Sthe_0891 Sthe_0891 nadA nadA prs prs Sthe_0776 Sthe_0776 Sthe_0734 Sthe_0734 coaE coaE coaX-2 coaX-2 pfp pfp pyrF pyrF Sthe_0607 Sthe_0607 Sthe_0547 Sthe_0547 coaX coaX cmk cmk Sthe_0415 Sthe_0415 gmk gmk Sthe_0376 Sthe_0376 Sthe_0230 Sthe_0230 Sthe_0091 Sthe_0091 Sthe_2551 Sthe_2551 Sthe_2632 Sthe_2632 Sthe_2681 Sthe_2681 Sthe_2721 Sthe_2721 Sthe_2814 Sthe_2814 Sthe_2929 Sthe_2929 Sthe_2988 Sthe_2988 Sthe_3028 Sthe_3028 pyrE-2 pyrE-2 Sthe_3132 Sthe_3132 Sthe_3161 Sthe_3161 pyrD pyrD Sthe_3224 Sthe_3224 Sthe_3227 Sthe_3227 Sthe_3238 Sthe_3238 Sthe_3363 Sthe_3363 Sthe_3458 Sthe_3458 Sthe_3459 Sthe_3459 nadE nadE Sthe_3475 Sthe_3475 Sthe_3477 Sthe_3477 Sthe_3523 Sthe_3523 atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB pyrG pyrG purM purM purH purH acsA acsA dacA dacA Sthe_1633 Sthe_1633 gpmI gpmI eno eno purA purA nadD nadD pyrH pyrH purE purE accD accD accA-2 accA-2 pyrB pyrB coaD coaD Sthe_1933 Sthe_1933 pdhA pdhA Sthe_1938 Sthe_1938 Sthe_2003 Sthe_2003 Sthe_2025 Sthe_2025 Sthe_2029 Sthe_2029 Sthe_2057 Sthe_2057 Sthe_2070 Sthe_2070 Sthe_2121 Sthe_2121 Sthe_2195 Sthe_2195 Sthe_2207 Sthe_2207 prs-2 prs-2 dcd dcd ndk ndk Sthe_2381 Sthe_2381 guaB guaB Sthe_2511 Sthe_2511
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atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (469 aa)
atpCATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (149 aa)
Sthe_1390KEGG: chy:CHY_0678 allantoinase; TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; Amidohydrolase 3. (460 aa)
purDKEGG: mta:Moth_2043 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family. (429 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (531 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (209 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (374 aa)
Sthe_1339PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: spe:Spro_2338 hypothetical protein. (154 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
Sthe_1297Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (228 aa)
Sthe_1293TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: dsy:DSY3932 hypothetical protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (439 aa)
purCKEGG: glo:Glov_3047 phosphoribosylaminoimidazole- succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase. (299 aa)
purSPhosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (101 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (236 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (734 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (480 aa)
Sthe_1261TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; cytidylyltransferase; Riboflavin kinase; KEGG: rsa:RSal33209_0668 FMN adenylyltransferase; Belongs to the ribF family. (331 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: mta:Moth_0263 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
Sthe_1220TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rrs:RoseRS_1334 MazG family protein. (466 aa)
nnrECarbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (536 aa)
Sthe_1127PFAM: phosphoribosylglycinamide synthetase; ATP- dependent carboxylate-amine ligase domain protein ATP- grasp; KEGG: cau:Caur_2007 phosphoribosylglycinamide synthetase. (426 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (607 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (229 aa)
Sthe_1027Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
Sthe_0970KEGG: hau:Haur_3170 hypothetical protein. (112 aa)
nadKATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (281 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (201 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; protein of unknown function DUF201; phosphoribosylglycinamide synthetase; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: det:DET1202 carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1080 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: mta:Moth_0881 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (386 aa)
pyrCDihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (458 aa)
Sthe_0891TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; KEGG: dge:Dgeo_2136 competence-damaged protein; Belongs to the CinA family. (410 aa)
nadAQuinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (336 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa)
Sthe_0776KEGG: dau:Daud_1636 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (189 aa)
Sthe_0734(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (748 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa)
coaX-2Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (258 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (402 aa)
pyrFTIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: rrs:RoseRS_0190 orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (277 aa)
Sthe_0607TIGRFAM: 3-carboxy-cis,cis-muconate cycloisomerase; PFAM: fumarate lyase; KEGG: rme:Rmet_4015 3-carboxy-cis,cis-muconate cycloisomerase. (448 aa)
Sthe_0547ATPase, FliI/YscN family; KEGG: mta:Moth_0774 ATPase FliI/YscN; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (442 aa)
coaXPutative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (257 aa)
cmkKEGG: rrs:RoseRS_0324 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (227 aa)
Sthe_0415KEGG: cau:Caur_2915 deoxyguanosinetriphosphate triphosphohydrolase-like protein; TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; Belongs to the dGTPase family. Type 2 subfamily. (351 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (217 aa)
Sthe_0376acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (457 aa)
Sthe_0230Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase E1 component; KEGG: tte:TTE0186 thiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit. (324 aa)
Sthe_0091PFAM: thioesterase superfamily protein; KEGG: cth:Cthe_2687 thioesterase superfamily protein. (163 aa)
Sthe_2551KEGG: xac:XAC2521 uracil phosphoribosyltransferase. (233 aa)
Sthe_2632PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: scl:sce3000 hypothetical protein. (438 aa)
Sthe_2681Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (220 aa)
Sthe_2721PFAM: CMP/dCMP deaminase zinc-binding; KEGG: dCMP deaminase; Dcd1p; K01493 dCMP deaminase. (191 aa)
Sthe_2814acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (467 aa)
Sthe_2929TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase; Amidohydrolase 3; KEGG: bch:Bcen2424_6618 dihydropyrimidinase. (473 aa)
Sthe_2988PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: predicted protein; K07023 putative hydrolases of HD superfamily. (207 aa)
Sthe_3028Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (563 aa)
pyrE-2Phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (214 aa)
Sthe_3132Pyruvate dehydrogenase (acetyl-transferring); PFAM: dehydrogenase E1 component; KEGG: azo:azo3867 acetoin dehydrogenase, alpha subunit. (345 aa)
Sthe_3161KEGG: plu:plu0860 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase. (326 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (364 aa)
Sthe_3224PFAM: dehydrogenase E1 component; KEGG: pfl:PFL_2170 acetoin dehydrogenase E1 component, alpha subunit. (333 aa)
Sthe_3227ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (346 aa)
Sthe_3238TIGRFAM: deoxycytidine triphosphate deaminase; KEGG: gbm:Gbem_2156 deoxycytidine triphosphate deaminase. (171 aa)
Sthe_3363PFAM: protein of unknown function DUF84; KEGG: saz:Sama_2774 NTPase. (192 aa)
Sthe_3458PFAM: deoxyUTP pyrophosphatase; KEGG: dUTP diphosphatase Dut, putative; K01520 dUTP pyrophosphatase. (179 aa)
Sthe_3459PFAM: Quinolinate phosphoribosyl transferase; Nicotinate phosphoribosyltransferase-like; KEGG: dma:DMR_20580 hypothetical protein; Belongs to the NAPRTase family. (393 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (247 aa)
Sthe_3475PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: rpb:RPB_0277 dihydrolipoamide acetyltransferase. (467 aa)
Sthe_3477PFAM: dehydrogenase E1 component; KEGG: ade:Adeh_1827 3-methyl-2-oxobutanoate dehydrogenase (lipoamide). (340 aa)
Sthe_3523PFAM: AMP-dependent synthetase and ligase; KEGG: dal:Dalk_0007 AMP-dependent synthetase and ligase. (552 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (289 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (507 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa)
atpFATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (167 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (279 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (553 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; KEGG: deb:DehaBAV1_1223 phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (363 aa)
purHKEGG: cau:Caur_2058 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein; SMART: AICARFT/IMPCHase bienzyme formylation region. (509 aa)
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (659 aa)
dacAProtein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (301 aa)
Sthe_1633PFAM: phosphoribosyltransferase; KEGG: hau:Haur_2887 phosphoribosyltransferase. (155 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate- independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (519 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (433 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (205 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (248 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (160 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (306 aa)
accA-2acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (294 aa)
pyrBKEGG: aspartate carabmoyltransferase, chloroplast / aspartate transcarbamylase / ATCase (PYRB); K00609 aspartate carbamoyltransferase catalytic chain; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (168 aa)
Sthe_1933PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: rrs:RoseRS_1726 dihydrolipoyllysine-residue succinyltransferase. (443 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (336 aa)
Sthe_1938KEGG: acr:Acry_0178 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (476 aa)
Sthe_2003TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: cau:Caur_1378 acetyl-CoA carboxylase, biotin carboxylase. (592 aa)
Sthe_2025PFAM: AMP-dependent synthetase and ligase; KEGG: pcl:Pcal_0155 AMP-dependent synthetase and ligase. (641 aa)
Sthe_2029PFAM: CinA domain protein; KEGG: pth:PTH_1300 nucleotide-utilizing enzyme; Belongs to the CinA family. (176 aa)
Sthe_20572-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (442 aa)
Sthe_2070PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: stp:Strop_1957 glyoxalase/bleomycin resistance protein/dioxygenase. (126 aa)
Sthe_2121Transketolase domain protein; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (801 aa)
Sthe_2195KEGG: gsu:GSU1936 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (287 aa)
Sthe_2207PFAM: aspartate dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: reu:Reut_B3576 L-aspartate dehydrogenase. (263 aa)
prs-2Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (197 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (150 aa)
Sthe_2381PFAM: AMP-dependent synthetase and ligase; KEGG: sth:STH1025 acetyl-coenzyme A synthetase. (657 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (511 aa)
Sthe_2511PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: xca:xccb100_0266 methylcrotonoyl-CoA carboxylase alpha chain. (647 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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