STRINGSTRING
trpS trpS Sthe_3185 Sthe_3185 Sthe_3164 Sthe_3164 Sthe_3130 Sthe_3130 Sthe_2974 Sthe_2974 Sthe_2955 Sthe_2955 Sthe_2682 Sthe_2682 thiI thiI metG metG Sthe_2646 Sthe_2646 Sthe_2520 Sthe_2520 Sthe_2518 Sthe_2518 Sthe_2497 Sthe_2497 hypA hypA Sthe_2484 Sthe_2484 Sthe_2455 Sthe_2455 trmH trmH mnmA mnmA Sthe_2353 Sthe_2353 Sthe_2346 Sthe_2346 Sthe_2331 Sthe_2331 Sthe_2317 Sthe_2317 argS argS Sthe_2278 Sthe_2278 rnc rnc Sthe_2189 Sthe_2189 Sthe_2174 Sthe_2174 Sthe_2120 Sthe_2120 Sthe_2109 Sthe_2109 gltX gltX Sthe_2084 Sthe_2084 rplY rplY Sthe_2043 Sthe_2043 Sthe_2022 Sthe_2022 Sthe_2016 Sthe_2016 rsmH rsmH Sthe_1974 Sthe_1974 Sthe_1957 Sthe_1957 rsmI rsmI gatC gatC gatA gatA prfA prfA Sthe_1886 Sthe_1886 rimM rimM rpsP rpsP rsmG rsmG Sthe_1849 Sthe_1849 Sthe_1845 Sthe_1845 Sthe_1831 Sthe_1831 Sthe_1822 Sthe_1822 rlmN rlmN Sthe_1818 Sthe_1818 rpmE rpmE rpmA rpmA rplU rplU frr frr tsf tsf rpsB rpsB Sthe_1689 Sthe_1689 Sthe_1674 Sthe_1674 pheT pheT pheS pheS gatB gatB mnmG mnmG serS serS valS valS tuf-2 tuf-2 rpmG rpmG nusG nusG rplK rplK rplA rplA rplJ rplJ rplL rplL rplI rplI Sthe_1594 Sthe_1594 cysS cysS Sthe_1560 Sthe_1560 alaS alaS rpsO rpsO pnp pnp Sthe_1466 Sthe_1466 rpsF rpsF rpsR rpsR rimO rimO leuS leuS rnz rnz Sthe_1344 Sthe_1344 proS proS Sthe_1294 Sthe_1294 tyrS tyrS truB truB rbfA rbfA infB infB nusA nusA Sthe_1245 Sthe_1245 Sthe_1242 Sthe_1242 Sthe_1222 Sthe_1222 aspS aspS lepA lepA rpsT rpsT sigA-2 sigA-2 pth pth tgt tgt fmt fmt Sthe_1175 Sthe_1175 infC infC rpmI rpmI rplT rplT Sthe_1169 Sthe_1169 Sthe_1150 Sthe_1150 Sthe_1124 Sthe_1124 Sthe_1114 Sthe_1114 lysS lysS Sthe_1101 Sthe_1101 infA-2 infA-2 Sthe_1071 Sthe_1071 rpsI rpsI rplM rplM truA truA rplQ rplQ rpoA rpoA rpsD-2 rpsD-2 rpsK rpsK rpsM rpsM rpmJ rpmJ infA infA rplO rplO rpmD rpmD rpsE rpsE rplR rplR rplF rplF rpsH rpsH rpsZ rpsZ rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ tuf tuf fusA fusA rpsG rpsG rpsL rpsL rpoC rpoC rpoB rpoB miaB miaB rho rho smpB smpB trmD trmD rnj-2 rnj-2 Sthe_0938 Sthe_0938 tsaD tsaD Sthe_0914 Sthe_0914 Sthe_0913 Sthe_0913 Sthe_0912 Sthe_0912 Sthe_0907 Sthe_0907 ybeY ybeY Sthe_0879 Sthe_0879 Sthe_0875 Sthe_0875 rsmA rsmA efp efp tilS tilS sigA sigA prfB prfB selA selA Sthe_0675 Sthe_0675 rpsU rpsU Sthe_0636 Sthe_0636 Sthe_0609 Sthe_0609 Sthe_0569 Sthe_0569 Sthe_0501 Sthe_0501 Sthe_0495 Sthe_0495 hisS hisS rplS rplS Sthe_0470 Sthe_0470 Sthe_0468 Sthe_0468 glyQS glyQS Sthe_0461 Sthe_0461 Sthe_0459 Sthe_0459 thrS thrS Sthe_0436 Sthe_0436 rph rph Sthe_0417 Sthe_0417 def def Sthe_0380 Sthe_0380 nusB nusB rpmF rpmF Sthe_0337 Sthe_0337 rpsD rpsD rnj rnj Sthe_0316 Sthe_0316 mnmE mnmE rnpA rnpA rpmH rpmH Sthe_0123 Sthe_0123 Sthe_0094 Sthe_0094 cysS-2 cysS-2 Sthe_3493 Sthe_3493 Sthe_3492 Sthe_3492 Sthe_3489 Sthe_3489 Sthe_3473 Sthe_3473 Sthe_3433 Sthe_3433 Sthe_3392 Sthe_3392 Sthe_3345 Sthe_3345 Sthe_3293 Sthe_3293 Sthe_3287 Sthe_3287 miaA miaA Sthe_3255 Sthe_3255 rtcB rtcB Sthe_3237 Sthe_3237 Sthe_3197 Sthe_3197
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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gene neighborhood
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trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (348 aa)
Sthe_3185PFAM: Abortive infection protein; KEGG: dol:Dole_0921 abortive infection protein. (279 aa)
Sthe_3164RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-70 factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; KEGG: acp:A2cp1_3324 RNA polymerase, sigma-24 subunit, ECF subfamily. (307 aa)
Sthe_3130RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (359 aa)
Sthe_2974PFAM: DsrE family protein; KEGG: ank:AnaeK_1829 hypothetical protein. (121 aa)
Sthe_2955Putative RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; Tetratricopeptide TPR_2 repeat protein; KEGG: pap:PSPA7_4032 ECF subfamily RNA polymerase sigma factor. (418 aa)
Sthe_2682TIGRFAM: RNA methyltransferase, TrmA family; PFAM: deoxyribonuclease/rho motif-related TRAM; protein of unknown function Met10; (Uracil-5)- methyltransferase; KEGG: dol:Dole_1585 RNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (400 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (593 aa)
Sthe_2646TIGRFAM: methionyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); KEGG: afw:Anae109_3095 tRNA synthetase class I (M). (525 aa)
Sthe_2520PFAM: Amidase; KEGG: bpt:Bpet1417 glutamyl-tRNA(Gln) amidotransferase subunit A; Belongs to the amidase family. (472 aa)
Sthe_2518TIGRFAM: signal peptidase I; PFAM: Peptidase S24/S26A/S26B, conserved region; Peptidase S26, conserved region; KEGG: dvm:DvMF_2718 signal peptidase I; Belongs to the peptidase S26 family. (239 aa)
Sthe_2497TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; KEGG: dds:Ddes_1497 hydrogenase accessory protein HypB. (227 aa)
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (114 aa)
Sthe_2484PFAM: peptidase T2 asparaginase 2; KEGG: ftn:FTN_0588 asparaginase. (323 aa)
Sthe_2455TIGRFAM: metal dependent phophohydrolase; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; KEGG: rxy:Rxyl_2803 polynucleotide adenylyltransferase region; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (478 aa)
trmHtRNA guanosine-2'-O-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (190 aa)
mnmAtRNA(5-methylaminomethyl-2-thiouridylate)-methyl transferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (353 aa)
Sthe_2353Transcriptional regulator, LuxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; regulatory protein LuxR; sigma-70 region 4 domain protein; KEGG: sth:STH2528 RNA polymerase ECF-type sigma factor. (198 aa)
Sthe_2346RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: rca:Rcas_0988 ECF subfamily RNA polymerase sigma-24 factor. (181 aa)
Sthe_2331KEGG: sfu:Sfum_0315 hypothetical protein. (323 aa)
Sthe_2317PFAM: Amidase; KEGG: sus:Acid_7160 amidase. (467 aa)
argSarginyl-tRNA synthetase; KEGG: bba:Bd2027 hypothetical protein; TIGRFAM: arginyl-tRNA synthetase. (724 aa)
Sthe_2278PFAM: Abortive infection protein; KEGG: mma:MM_0503 hypothetical protein. (259 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (259 aa)
Sthe_2189RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: rca:Rcas_2697 ECF subfamily RNA polymerase sigma-24 factor. (194 aa)
Sthe_2174RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: cts:Ctha_1394 RNA polymerase, sigma-24 subunit, ECF subfamily. (182 aa)
Sthe_2120PFAM: AIR synthase related protein domain protein; AIR synthase related protein; KEGG: det:DET1592 AIR synthase domain-containing protein. (359 aa)
Sthe_2109TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24 and S26 domain protein; KEGG: amt:Amet_0492 peptidase S26B, signal peptidase. (356 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (497 aa)
Sthe_2084RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: ank:AnaeK_0241 RNA polymerase, sigma-24 subunit, ECF subfamily. (237 aa)
rplYRibosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (218 aa)
Sthe_2043RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. (219 aa)
Sthe_2022PFAM: CMP/dCMP deaminase zinc-binding; KEGG: sth:STH11 putative Cu-binding protein. (148 aa)
Sthe_2016TIGRFAM: export-related chaperone CsaA; PFAM: t-RNA-binding domain protein; KEGG: rxy:Rxyl_3199 secretion chaperone CsaA. (109 aa)
rsmHS-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (326 aa)
Sthe_1974TIGRFAM: selenocysteine-specific translation elongation factor; small GTP-binding protein; PFAM: protein synthesis factor GTP-binding; Elongation factor SelB winged helix 3; Elongation factor SelB winged helix 2; elongation factor Tu domain 2 protein; KEGG: cau:Caur_0243 selenocysteine-specific translation elongation factor. (630 aa)
Sthe_1957PFAM: peptidase M48 Ste24p; peptidase M56 BlaR1; KEGG: aba:Acid345_0572 STE24 endopeptidase. (414 aa)
rsmIUroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (285 aa)
gatCglutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (97 aa)
gatAglutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (497 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (361 aa)
Sthe_1886PFAM: Protein of unknown function methylase putative; KEGG: cau:Caur_2401 methyltransferase. (194 aa)
rimM16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (178 aa)
rpsPTIGRFAM: ribosomal protein S16; PFAM: ribosomal protein S16; KEGG: lme:LEUM_1485 SSU ribosomal protein S16P; Belongs to the bacterial ribosomal protein bS16 family. (107 aa)
rsmGMethyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (243 aa)
Sthe_1849RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (341 aa)
Sthe_1845TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; KEGG: hau:Haur_0125 RNA polymerase, sigma 54 subunit, RpoN. (472 aa)
Sthe_1831PFAM: Amidase; KEGG: sma:SAV_7269 amidase. (466 aa)
Sthe_1822PFAM: Amidase; KEGG: cau:Caur_1377 amidase. (547 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (347 aa)
Sthe_1818Hypothetical protein; KEGG: rpt:Rpal_1851 high-affinity nickel- transporter. (284 aa)
rpmERibosomal protein L31; Binds the 23S rRNA. (110 aa)
rpmATIGRFAM: ribosomal protein L27; PFAM: ribosomal protein L27; KEGG: gme:Gmet_3196 50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (97 aa)
rplURibosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
frrRibosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
tsfTranslation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (186 aa)
rpsBTIGRFAM: ribosomal protein S2; PFAM: ribosomal protein S2; KEGG: afl:Aflv_1709 ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (269 aa)
Sthe_1689Protein of unknown function DUF558; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (249 aa)
Sthe_1674Histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; KEGG: rca:Rcas_2915 histidyl-tRNA synthetase. (495 aa)
pheTKEGG: hau:Haur_4633 phenylalanyl-tRNA synthetase, beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (818 aa)
pheSTIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: rca:Rcas_1438 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (347 aa)
gatBglutamyl-tRNA(Gln) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (482 aa)
mnmGGlucose-inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (663 aa)
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (427 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (894 aa)
tuf-2Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa)
rpmGTIGRFAM: ribosomal protein L33; PFAM: ribosomal protein L33; KEGG: dth:DICTH_1264 ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (56 aa)
nusGNusG antitermination factor; Participates in transcription elongation, termination and antitermination. (200 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (241 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (178 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (132 aa)
rplIRibosomal protein L9; Binds to the 23S rRNA. (183 aa)
Sthe_1594TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; KEGG: cau:Caur_2072 RNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (252 aa)
cysSKEGG: rrs:RoseRS_3036 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Belongs to the class-I aminoacyl-tRNA synthetase family. (468 aa)
Sthe_1560Holliday junction resolvase YqgF; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (143 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (879 aa)
rpsORibosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (790 aa)
Sthe_1466PFAM: B3/4 domain protein; KEGG: asu:Asuc_1302 B3/4 domain-containing protein. (236 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (109 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (128 aa)
rimOMiaB-like tRNA modifying enzyme YliG; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (466 aa)
leuSTIGRFAM: leucyl-tRNA synthetase; KEGG: rxy:Rxyl_3202 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (824 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (304 aa)
Sthe_1344PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: amr:AM1_D0197 hydrogenase expression/formation protein HypE. (340 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (483 aa)
Sthe_1294MiaB-like tRNA modifying enzyme; KEGG: drm:Dred_2492 RNA modification protein; TIGRFAM: MiaB-like tRNA modifying enzyme; RNA modification enzyme, MiaB family; PFAM: Protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. (449 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (407 aa)
truBtRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (299 aa)
rbfARibosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (135 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (633 aa)
nusANusA antitermination factor; Participates in both transcription termination and antitermination. (443 aa)
Sthe_1245KEGG: rca:Rcas_3523 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; Belongs to the peptidase S26 family. (234 aa)
Sthe_1242RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: sgr:SGR_2306 RNA polymerase ECF-subfamily sigma factor. (204 aa)
Sthe_1222PFAM: Amidase; KEGG: afu:AF1954 Glu-tRNA amidotransferase, subunit A (GatA-1); Belongs to the amidase family. (514 aa)
aspSaspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (609 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (610 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (91 aa)
sigA-2RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (390 aa)
pthpeptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (214 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (414 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (314 aa)
Sthe_1175KEGG: small GTP-binding protein; TIGRFAM: small GTP-binding protein; PFAM: Ras family protein; Miro domain protein; SMART: Ras small GTPase, Rab type; Ras small GTPase, Rho type; Ras small GTPase, Ras type. (167 aa)
infCTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (204 aa)
rpmITIGRFAM: ribosomal protein L35; PFAM: ribosomal protein L35; KEGG: deb:DehaBAV1_0679 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (117 aa)
Sthe_1169PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; KEGG: hau:Haur_4637 tRNA/rRNA methyltransferase (SpoU); Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (293 aa)
Sthe_1150PFAM: formyl transferase domain protein; KEGG: plu:plu1413 hypothetical protein. (230 aa)
Sthe_1124PFAM: formyl transferase domain protein; KEGG: cau:Caur_2005 formyl transferase domain- containing protein. (230 aa)
Sthe_1114KEGG: rca:Rcas_4329 hypothetical protein. (319 aa)
lysSTIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: cau:Caur_1226 lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (513 aa)
Sthe_1101PFAM: biotin/lipoate A/B protein ligase; KEGG: mta:Moth_1939 biotin/lipoate A/B protein ligase. (284 aa)
infA-2Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (91 aa)
Sthe_1071PFAM: beta-lactamase domain protein; KEGG: fre:Franean1_3962 beta-lactamase domain- containing protein. (267 aa)
rpsIPFAM: ribosomal protein S9; KEGG: cau:Caur_2400 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (147 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (271 aa)
rplQTIGRFAM: ribosomal protein L17; PFAM: ribosomal protein L17; KEGG: mrd:Mrad2831_2190 ribosomal protein L17. (117 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa)
rpsD-2Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (214 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (136 aa)
rpsMRibosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (124 aa)
rpmJTIGRFAM: ribosomal protein L36; PFAM: ribosomal protein L36; KEGG: lch:Lcho_3927 ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
rpmDTIGRFAM: ribosomal protein L30; PFAM: ribosomal protein L30; KEGG: cau:Caur_2387 ribosomal protein L30. (64 aa)
rpsERibosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (180 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (125 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (181 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsZRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (181 aa)
rplXRibosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (108 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (95 aa)
rpmCTIGRFAM: ribosomal protein L29; PFAM: ribosomal protein L29; KEGG: xau:Xaut_1687 ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (73 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (150 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (224 aa)
rplVRibosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (114 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (94 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
rplWRibosomal protein L25/L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa)
rplDRibosomal protein L4/L1e; Forms part of the polypeptide exit tunnel. (209 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (216 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (106 aa)
tufTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (701 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsLRibosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (141 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1479 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1159 aa)
miaBRNA modification enzyme, MiaB family; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (460 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (417 aa)
smpBSsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (160 aa)
trmDtRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (243 aa)
rnj-2Beta-lactamase domain protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (555 aa)
Sthe_0938PFAM: B3/4 domain protein; KEGG: pac:PPA2209 hypothetical protein. (244 aa)
tsaDMetalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (371 aa)
Sthe_0914TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; KEGG: rca:Rcas_4079 ribosomal-protein-alanine acetyltransferase. (229 aa)
Sthe_0913PFAM: peptidase M22 glycoprotease; KEGG: hau:Haur_4976 peptidase M22 glycoprotease. (235 aa)
Sthe_0912PFAM: protein of unknown function UPF0079; KEGG: cau:Caur_1991 hypothetical protein. (178 aa)
Sthe_0907PFAM: Amidase; KEGG: bra:BRADO4401 putative amidase; Belongs to the amidase family. (469 aa)
ybeYProtein of unknown function UPF0054; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (153 aa)
Sthe_0879PFAM: Gas vesicle synthesis GvpLGvpF; KEGG: pth:PTH_0426 hypothetical protein. (252 aa)
Sthe_0875PFAM: Gas vesicle synthesis GvpLGvpF; KEGG: gur:Gura_2834 gas vesicle synthesis GvpLGvpF. (257 aa)
rsmADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (293 aa)
efpTranslation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (186 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (468 aa)
sigARNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (538 aa)
prfBConserved hypothetical protein; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (369 aa)
selAL-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (478 aa)
Sthe_0675RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; KEGG: rrs:RoseRS_2793 ECF subfamily RNA polymerase sigma-24 factor. (208 aa)
rpsUTIGRFAM: ribosomal protein S21; KEGG: cau:Caur_0492 ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (70 aa)
Sthe_0636PFAM: Domain of unknown function DUF1858; KEGG: hau:Haur_1537 hypothetical protein. (281 aa)
Sthe_0609RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; KEGG: rca:Rcas_0731 ECF subfamily RNA polymerase sigma-24 factor. (224 aa)
Sthe_0569RNA polymerase, sigma 28 subunit, FliA/WhiG; KEGG: ace:Acel_1546 RNA polymerase sigma factor WhiG; TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma- 70 region 3 domain protein. (264 aa)
Sthe_0501Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (313 aa)
Sthe_0495PFAM: RNA binding S1 domain protein; SMART: RNA binding S1 domain protein; KEGG: cau:Caur_2474 RNA-binding S1 domain- containing protein. (459 aa)
hisSKEGG: rca:Rcas_0121 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein. (455 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (123 aa)
Sthe_0470RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: pth:PTH_2134 DNA-directed RNA polymerase specialized sigma subunit, sigma24-like protein; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
Sthe_0468PFAM: Abortive infection protein; KEGG: cau:Caur_2017 abortive infection protein. (315 aa)
glyQSglycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (469 aa)
Sthe_0461PFAM: domain of unknown function DUF1730; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sus:Acid_3576 hypothetical protein. (387 aa)
Sthe_0459TIGRFAM: translation elongation factor G; small GTP- binding protein; PFAM: protein synthesis factor GTP-binding; elongation factor G domain protein; elongation factor Tu domain 2 protein; elongation factor G domain IV; KEGG: mta:Moth_1142 elongation factor G. (693 aa)
thrSTIGRFAM: threonyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; Threonyl/alanyl tRNA synthetase SAD; KEGG: deb:DehaBAV1_0681 Ser-tRNA(Thr) hydrolase / threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (596 aa)
Sthe_0436PFAM: pseudouridine synthase; RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; KEGG: rca:Rcas_0166 pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (337 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (246 aa)
Sthe_0417TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC domain; KEGG: hbu:Hbut_0770 hypothetical protein; Belongs to the SUA5 family. (216 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (177 aa)
Sthe_0380PFAM: Fibronectin-binding A domain protein; protein of unknown function DUF814; KEGG: rca:Rcas_4287 fibronectin-binding A domain- containing protein. (597 aa)
nusBNusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (140 aa)
rpmFTIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein; KEGG: rca:Rcas_1804 ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (68 aa)
Sthe_0337TIGRFAM: isoleucyl-tRNA synthetase; KEGG: rxy:Rxyl_2428 isoleucyl-tRNA synthetase. (1060 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (203 aa)
rnjBeta-lactamase domain protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (554 aa)
Sthe_0316PFAM: Threonyl/alanyl tRNA synthetase SAD; KEGG: rxy:Rxyl_2571 Ala-tRNA(Pro) hydrolase. (247 aa)
mnmEtRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (466 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (129 aa)
rpmHTIGRFAM: ribosomal protein L34; PFAM: ribosomal protein L34; KEGG: hau:Haur_0767 ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (54 aa)
Sthe_0123KEGG: ace:Acel_2052 cysteinyl-tRNA synthetase-like. (267 aa)
Sthe_0094Transcriptional regulator, LuxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; regulatory protein LuxR; sigma-70 region 4 domain protein; KEGG: rfr:Rfer_4146 sigma-24 (FecI-like); Belongs to the sigma-70 factor family. ECF subfamily. (191 aa)
cysS-2KEGG: aeh:Mlg_1810 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; tRNA synthetase class I (M); Belongs to the class-I aminoacyl-tRNA synthetase family. (399 aa)
Sthe_3493KEGG: oan:Oant_2218 biotin/lipoate A/B protein ligase. (91 aa)
Sthe_3492PFAM: biotin/lipoate A/B protein ligase; KEGG: bbr:BB2891 putative lipoate-protein ligase A. (260 aa)
Sthe_3489PFAM: Amidase; KEGG: reu:Reut_B5142 amidase. (506 aa)
Sthe_3473KEGG: psb:Psyr_0099 hypothetical protein. (73 aa)
Sthe_3433TIGRFAM: CRISPR-associated protein, Cse3 family; PFAM: CRISPR-associated protein CT1974; KEGG: scl:sce0560 hypothetical protein. (257 aa)
Sthe_3392Formate dehydrogenase accessory protein; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (287 aa)
Sthe_3345RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: rso:RSc2361 RNA polymerase sigma-E factor sigma-24 homolog transcription regulator protein; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
Sthe_3293PFAM: Amidase; KEGG: mxa:MXAN_3566 amidase. (542 aa)
Sthe_3287KEGG: ank:AnaeK_1718 hypothetical protein. (416 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (330 aa)
Sthe_3255PFAM: Amidase; KEGG: bbr:BB4983 amidase; Belongs to the amidase family. (474 aa)
rtcBPFAM: protein of unknown function UPF0027; KEGG: dal:Dalk_3935 protein of unknown function UPF0027; Belongs to the RtcB family. (487 aa)
Sthe_3237PFAM: Amidase; KEGG: aeh:Mlg_2453 amidase. (539 aa)
Sthe_3197RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; sigma-70 region 4 domain protein; KEGG: mxa:MXAN_3686 ECF subfamily RNA polymerase sigma factor. (193 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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