STRINGSTRING
hldE hldE Sthe_1312 Sthe_1312 pnp pnp polA polA dacA dacA Sthe_1687 Sthe_1687 nadD nadD Sthe_1739 Sthe_1739 Sthe_1749 Sthe_1749 Sthe_1751 Sthe_1751 Sthe_1837 Sthe_1837 glgC glgC ispD ispD Sthe_0659 Sthe_0659 rph rph dnaG dnaG Sthe_0384 Sthe_0384 Sthe_0314 Sthe_0314 Sthe_0227 Sthe_0227 glmU glmU Sthe_1845 Sthe_1845 coaD coaD dnaX dnaX dinB dinB Sthe_2045 Sthe_2045 Sthe_2242 Sthe_2242 Sthe_2291 Sthe_2291 Sthe_2455 Sthe_2455 fbiD fbiD thiI thiI Sthe_2834 Sthe_2834 Sthe_2835 Sthe_2835 Sthe_3472 Sthe_3472 Sthe_0855 Sthe_0855 dinG dinG mobA mobA rpoB rpoB rpoC rpoC rpoA rpoA Sthe_1214 Sthe_1214 Sthe_1261 Sthe_1261 Sthe_1301 Sthe_1301
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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textmining
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hldECytidyltransferase-related domain protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (507 aa)
Sthe_1312DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (379 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (790 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (915 aa)
dacAProtein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (301 aa)
Sthe_1687PFAM: Nucleotidyl transferase; KEGG: hau:Haur_1221 nucleotidyl transferase. (337 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (205 aa)
Sthe_1739PFAM: phosphatidate cytidylyltransferase; KEGG: hau:Haur_3934 phosphatidate cytidylyltransferase; Belongs to the CDS family. (284 aa)
Sthe_1749PFAM: PfkB domain protein; KEGG: cau:Caur_2356 ribokinase-like domain- containing protein. (339 aa)
Sthe_1751TIGRFAM: cytidyltransferase-related domain protein; PFAM: cytidylyltransferase; KEGG: cau:Caur_2177 cytidyltransferase-like protein. (171 aa)
Sthe_1837KEGG: hau:Haur_1838 hypothetical protein. (371 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (427 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (234 aa)
Sthe_0659TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: rrs:RoseRS_3588 DNA polymerase III, delta prime subunit. (346 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (246 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (615 aa)
Sthe_0384PFAM: Nucleotidyl transferase; KEGG: hau:Haur_4821 mannose-1-phosphate guanylyltransferase (GDP). (358 aa)
Sthe_0314TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit; KEGG: swo:Swol_1124 hypothetical protein. (301 aa)
Sthe_0227KEGG: msm:MSMEG_1633 DNA polymerase III, alpha subunit, putative; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1095 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (464 aa)
Sthe_1845TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; KEGG: hau:Haur_0125 RNA polymerase, sigma 54 subunit, RpoN. (472 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (168 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (589 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (394 aa)
Sthe_2045DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein; KEGG: dau:Daud_0758 DNA-directed DNA polymerase. (397 aa)
Sthe_2242PFAM: zinc finger CHC2-family protein; SMART: zinc finger CHC2-family protein; KEGG: rba:RB6344 DNA primase. (198 aa)
Sthe_2291PFAM: Nucleotidyl transferase; KEGG: rci:RCIX198 glucose-1-phosphate thymidylyltransferase. (255 aa)
Sthe_2455TIGRFAM: metal dependent phophohydrolase; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase HD sub domain; KEGG: rxy:Rxyl_2803 polynucleotide adenylyltransferase region; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (478 aa)
fbiD2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (207 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
Sthe_2834PFAM: zinc finger CHC2-family protein; SMART: zinc finger CHC2-family protein; KEGG: hha:Hhal_1100 DNA primase. (214 aa)
Sthe_2835KEGG: pca:Pcar_0796 hypothetical protein. (672 aa)
Sthe_3472KEGG: plu:plu1458 hypothetical protein. (302 aa)
Sthe_0855KEGG: afe:Lferr_2703 PHP domain protein. (169 aa)
dinGExonuclease RNase T and DNA polymerase III; 3'-5' exonuclease. (966 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis MobB region containing protein; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (224 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1159 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1479 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa)
Sthe_1214TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cau:Caur_2419 DNA polymerase III, delta subunit. (340 aa)
Sthe_1261TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: FAD synthetase; cytidylyltransferase; Riboflavin kinase; KEGG: rsa:RSal33209_0668 FMN adenylyltransferase; Belongs to the ribF family. (331 aa)
Sthe_1301KEGG: det:DET1464 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; SMART: phosphoesterase PHP domain protein. (1167 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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