STRINGSTRING
Sthe_0425 Sthe_0425 clpB clpB Sthe_0459 Sthe_0459 Sthe_0496 Sthe_0496 lon-2 lon-2 Sthe_0547 Sthe_0547 Sthe_0572 Sthe_0572 Sthe_0635 Sthe_0635 Sthe_0642 Sthe_0642 Sthe_0687 Sthe_0687 obg obg Sthe_0771 Sthe_0771 ftsH1 ftsH1 uvrB uvrB mutL mutL Sthe_0921 Sthe_0921 ftsH2 ftsH2 fusA fusA tuf tuf Sthe_1207 Sthe_1207 lepA lepA infB infB Sthe_1297 Sthe_1297 ruvB ruvB Sthe_1351 Sthe_1351 clpX clpX Sthe_1401 Sthe_1401 Sthe_1508 Sthe_1508 Sthe_1527 Sthe_1527 hflX hflX Sthe_1590 Sthe_1590 Sthe_1596 Sthe_1596 tuf-2 tuf-2 mutL-2 mutL-2 uvrA uvrA ruvA ruvA mutS2 mutS2 Sthe_1816 Sthe_1816 ftsH3 ftsH3 Sthe_1852 Sthe_1852 Sthe_1853 Sthe_1853 recG recG Sthe_1974 Sthe_1974 ftsZ ftsZ Sthe_2011 Sthe_2011 Sthe_2047 Sthe_2047 Sthe_2091 Sthe_2091 Sthe_2092 Sthe_2092 Sthe_2126 Sthe_2126 Sthe_2282 Sthe_2282 Sthe_2383 Sthe_2383 Sthe_2497 Sthe_2497 Sthe_2570 Sthe_2570 ftsh4 ftsh4 Sthe_2858 Sthe_2858 Sthe_2862 Sthe_2862 Sthe_3009 Sthe_3009 rsgA rsgA Sthe_3134 Sthe_3134 Sthe_3245 Sthe_3245 Sthe_3342 Sthe_3342 Sthe_3363 Sthe_3363 Sthe_3399 Sthe_3399 lon lon mnmE mnmE smc smc Sthe_0312 Sthe_0312 ychF ychF ffh ffh ftsY ftsY Sthe_0393 Sthe_0393
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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Sthe_0425PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; magnesium chelatase ChlI subunit; SMART: AAA ATPase; KEGG: rrs:RoseRS_3807 recombination factor protein RarA. (460 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (870 aa)
Sthe_0459TIGRFAM: translation elongation factor G; small GTP- binding protein; PFAM: protein synthesis factor GTP-binding; elongation factor G domain protein; elongation factor Tu domain 2 protein; elongation factor G domain IV; KEGG: mta:Moth_1142 elongation factor G. (693 aa)
Sthe_0496PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Torsin; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; KEGG: deb:DehaBAV1_0051 ATPase; Belongs to the ClpA/ClpB family. (817 aa)
lon-2ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (837 aa)
Sthe_0547ATPase, FliI/YscN family; KEGG: mta:Moth_0774 ATPase FliI/YscN; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; SMART: AAA ATPase. (442 aa)
Sthe_0572PFAM: GTP-binding signal recognition particle SRP54 G- domain; SMART: AAA ATPase; KEGG: mta:Moth_0791 flagellar biosynthesis regulator FlhF. (358 aa)
Sthe_0635PFAM: protein of unknown function DUF59; KEGG: noc:Noc_1484 hypothetical protein. (109 aa)
Sthe_0642Protein of unknown function DUF59; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (365 aa)
Sthe_0687PFAM: Dynamin family protein; Miro domain protein; GTP-binding protein HSR1-related; KEGG: hau:Haur_2968 dynamin family protein. (588 aa)
obgGTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (466 aa)
Sthe_0771PFAM: UvrD/REP helicase; KEGG: cau:Caur_1305 UvrD/REP helicase. (738 aa)
ftsH1ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (653 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (664 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (578 aa)
Sthe_0921KEGG: rrs:RoseRS_3193 hypothetical protein. (375 aa)
ftsH2ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (652 aa)
fusATranslation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...] (701 aa)
tufTranslation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa)
Sthe_1207KEGG: nca:Noca_1798 LAO/AO transport system ATPase; TIGRFAM: LAO/AO transport system ATPase; PFAM: ArgK protein; SMART: AAA ATPase. (322 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (610 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (633 aa)
Sthe_1297Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (228 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa)
Sthe_1351TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: tfu:Tfu_3040 ATPase, E1-E2 type. (898 aa)
clpXSigma 54 interacting domain protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (419 aa)
Sthe_1401PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: cau:Caur_0984 ATPase. (321 aa)
Sthe_1508PFAM: AFG1-family ATPase; SMART: AAA ATPase; KEGG: lxx:Lxx10560 ATP/GTP-binding integral membrane protein. (329 aa)
Sthe_1527PFAM: protein of unknown function DUF59; KEGG: bld:BLi01205 YitW. (105 aa)
hflXGTP-binding proten HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (433 aa)
Sthe_1590PFAM: ATPase associated with various cellular activities AAA_3; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: cau:Caur_1865 ATPase. (338 aa)
Sthe_1596Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (447 aa)
tuf-2Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa)
mutL-2DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (585 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (964 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (193 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa)
Sthe_1816TIGRFAM: copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper ion binding protein; PFAM: E1-E2 ATPase-associated domain protein; Heavy metal transport/detoxification protein; Haloacid dehalogenase domain protein hydrolase; KEGG: rci:RCIX1517 Cu(2+)-binding/translocating P- type ATPase. (826 aa)
ftsH3ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (489 aa)
Sthe_1852KEGG: scl:sce0387 hypothetical protein. (557 aa)
Sthe_1853PFAM: NERD domain protein; KEGG: hau:Haur_1680 NERD domain-containing protein. (1361 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (824 aa)
Sthe_1974TIGRFAM: selenocysteine-specific translation elongation factor; small GTP-binding protein; PFAM: protein synthesis factor GTP-binding; Elongation factor SelB winged helix 3; Elongation factor SelB winged helix 2; elongation factor Tu domain 2 protein; KEGG: cau:Caur_0243 selenocysteine-specific translation elongation factor. (630 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (369 aa)
Sthe_2011TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid ac-diamide synthase; KEGG: pth:PTH_0822 septum formation inhibitor- activating ATPase. (287 aa)
Sthe_2047PFAM: CbbQ/NirQ/NorQ domain protein; ATPase associated with various cellular activities AAA_5; KEGG: tbd:Tbd_0869 nitric oxide reductase activation protein NorQ. (291 aa)
Sthe_2091KEGG: sus:Acid_0029 ATP-dependent nuclease subunit B-like protein. (1066 aa)
Sthe_2092PFAM: UvrD/REP helicase; KEGG: kra:Krad_4408 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1125 aa)
Sthe_2126PFAM: ATPase associated with various cellular activities AAA_3; ATPase associated with various cellular activities AAA_5; KEGG: sth:STH1770 methanol dehydrogenase regulatory protein. (315 aa)
Sthe_2282TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: rca:Rcas_0135 heavy metal translocating P- type ATPase. (800 aa)
Sthe_2383PFAM: ABC transporter related; KEGG: nfa:nfa43950 putative excision nuclease ABC subunit. (488 aa)
Sthe_2497TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; KEGG: dds:Ddes_1497 hydrogenase accessory protein HypB. (227 aa)
Sthe_2570TIGRFAM: phenylacetate-CoA oxygenase, PaaJ subunit; PFAM: protein of unknown function DUF59; KEGG: azo:azo0307 phenylacetic acid degradation protein PaaD. (160 aa)
ftsh4ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (658 aa)
Sthe_2858PFAM: ATPase associated with various cellular activities AAA_5; ATPase associated with various cellular activities AAA_3; von Willebrand factor type A; magnesium chelatase ChlI subunit; KEGG: xca:xccb100_0099 MoxR-like ATPase. (650 aa)
Sthe_2862PFAM: ATPase associated with various cellular activities AAA_5; ATPase associated with various cellular activities AAA_3; SMART: AAA ATPase; KEGG: mxa:MXAN_2475 putative transcriptional regulator. (301 aa)
Sthe_3009TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; Heavy metal transport/detoxification protein; Haloacid dehalogenase domain protein hydrolase; KEGG: mes:Meso_4212 heavy metal translocating P- type ATPase. (781 aa)
rsgARibosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (317 aa)
Sthe_3134PFAM: ATPase associated with various cellular activities AAA_3; ATPase associated with various cellular activities AAA_5; KEGG: gur:Gura_0187 ATPase. (332 aa)
Sthe_3245TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: yen:YE0588 putative cation-transporting P- type ATPase. (816 aa)
Sthe_3342TIGRFAM: copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: afw:Anae109_1015 copper-translocating P-type ATPase. (785 aa)
Sthe_3363PFAM: protein of unknown function DUF84; KEGG: saz:Sama_2774 NTPase. (192 aa)
Sthe_3399TIGRFAM: heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; KEGG: rpf:Rpic12D_5352 heavy metal translocating P- type ATPase. (637 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (815 aa)
mnmEtRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (466 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1183 aa)
Sthe_0312Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. (485 aa)
ychFGTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (368 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (321 aa)
Sthe_0393Chromosome segregation and condensation protein, ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (192 aa)
Your Current Organism:
Sphaerobacter thermophilus
NCBI taxonomy Id: 479434
Other names: S. thermophilus DSM 20745, Sphaerobacter thermophilus DSM 20745, Sphaerobacter thermophilus str. DSM 20745, Sphaerobacter thermophilus strain DSM 20745
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